Not Signed In - GDF5 lends a hand to finger abnormalities
Sat, 27 Aug 2005 06:00 AM EST
... In a study appearing online on August 25 in advance of print publication of the September 1 issue of the Journal of Clinical Investigation, Petra Seemann and colleagues describe two mutations in Growth and Differentiation Factor 5 (GDF5), a signaling molecule, that result in altered binding affinities to the BMP type 1 receptors giving rise to opposing phenotypes, brachydactyly type A2 (unusually short digits) and symphalangism (fusion of the hand joints)... click link for more info. ...
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