New Pathways Linking Liver Disease To Changes In The Central Nervous System

... Liver disease is often associated with "sickness behaviors," such as malaise, listlessness, anorexia, difficulty concentrating, and fatigue. In cholestatic liver diseases (where bile production is impaired) such as primary biliary cirrhosis, fatigue occurs in up to 86 percent of patients. Previous studies have suggested that these symptoms originate from changes to the central nervous system (CNS), but little is understood about how these changes occur or the pathways involved... click link for more info. ...