Enzyme Inhibitor May Provide New Strategy For Treating Certain Gastrointestinal Disorders

... Researchers have known that the enzyme Rho kinase (ROK) plays an important role in maintaining the tone of the internal anal sphincter (IAS), which is crucial for normal bowel functioning. When the IAS tone is too high, drugs that block ROK activity might hold a key to treating resulting chronic and severe disorders such as certain forms of constipation, hemorrhoids, anal fissures, Hirschsprung's disease and other similar gastrointestinal problems. ...