New Dopamine Brain Target Discovered; Potential Breakthrough For Schizophrenia Treatment

... A team of Canadian researchers, lead by Dr. Susan George and Dr. Brian O'Dowd at the Center for Addiction and Mental health, discovered a Gq/11-coupled signalling unit that triggers a calcium signal. This novel target is turned on by stimulating D1 and D2 dopamine receptors. This is the first time that a direct connection between dopamine and calcium signals has been reported. This data has significant implications for schizophrenia. ...