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Acquired Immune Deficiency Syndrome as related to Saquinavir


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Acquired Immunodeficiency Syndrome; AIDS; AIDS & HIV; AIDS - Neurological Complications; AIDS/HIV; HIV; HIV and AIDS; HI... 

Fortovase; Invirase 

AIDS (Acquired Immune Deficiency Syndrome) is the final and most serious stage of HIV disease, which causes severe damage to the immune system. AIDS begins when a person with HIV infection has a CD4 cell count below 200. (CD4 is also called "T-cell", a type of immune cell.) AIDS is also defined by numerous opportunistic infections and cancers that occur in the presence of HIV infection. Human immunodeficiency virus (HIV) causes AIDS. The virus attacks the immune system and leaves the body vulner...

Saquinavir hard-gel capsule 27 (Invirase) was the first PI approved by the FDA, in December 1995. A carboxamide derivative specifically designed to inhibit HIV proteinase and prevent post-translational formation of viral proteins, saquinavir is a potent inhibitor of HIV-1 and HIV-2 proteinases without prior metabolic activation. At 12 nM concentration, saquinavir has a 50% inhibition of normal HIV, and at 11 nM it has a 50% inhibition of ZDV-resistant HIV.


Acquired Immune Deficiency Syndrome as related to Saquinavir


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October 13, 2008


Page Updated: June 12, 2007
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