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Acid Reflux; Gastroesophageal Reflux; Gastroesophageal Reflux (GERD); Gastroesophageal Reflux Disease; Gastroesophageal ... |
Propulsid | |
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Gastroesophageal reflux disease, or GERD, occurs when the lower esophageal sphincter (LES) does not close properly and stomach contents leak back, or reflux, into the esophagus. The LES is a ring of muscle at the bottom of the esophagus that acts like a valve between the esophagus and stomach. The esophagus carries food from the mouth to the stomach.
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Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. It is sold under the trade names Prepulsid (Janssen-Ortho) and Propulsid (in the U.S.).
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GERD as related to Cisapride
- cisapride - Digestion and digestive-related information on MedicineNet ...
For further information, please read the GERD article. DOSING: Cisapride is given four times daily, 15 minutes before each meal and at bedtime.
- metoclopramide (Reglan) - drug class, medical uses, medication side ...
In patients with Gastroesophageal Reflux (GERD) , a weakened lower esophagus ... Like cisapride ( Propulsid ), metoclopramide also hastens the stomach emptying of solid ...
- GERD Treatments | Promotility Agents | Cisapride and Metoclopramide
Promotility Agents Help Move Gastrointestinal Contents Use promotility agents to stimulate movement. Promotility agents promote stomach emptying and relieve GERD symptoms.
- Medication for Treatment of GERD - Proton Pump Inhibitors (PPI)
Prescribed Medications for Treatment of GERD. PRESCRIPTION MEDICATIONS ... Prokinetic drugs like metoclopramide and cisapride are used in conjunction with other measures ...
- MEDICAL THERAPY OF GERD
Efficacy of Various Therapies in Attaining Goals of GERD Therapy. Treatment Goals of GERD ... European studies show that promotility drugs, such as cisapride, more effectively improved symptoms ...
- Postgraduate Medicine: Peptic Acid Disease Symposium ...
Cisapride has shown greater promise in the treatment of GERD. Cisapride enhances acetylcholine release from the myenteric plexus via 5-hydroxytryptamine receptors, thus increasing lower esophageal ...
- Dyspepsia - Wikipedia, the free encyclopedia
... often is a diagnosis of exclusion, meaning that endoscopy for other conditions such as GERD or ... reduction of up to 50%, but the studies evaluated to come to this conclusion used the drug cisapride ...
- Reflux Disease (GERD)
Gastroesophageal reflux disease (GERD) is a condition in which your esophagus becomes irritated ... One of these agents, cisapride (Propulsid), has been removed from the US market because of safety ...
- The Word on GERD - Patients - American College of Gastroenterology
Is it just a little Heartburn or something more serious? understanding gerd ... developments have greatly limited the availability of one of these agents, i.e. cisapride.
- Cisapride (Propulsid)
Cisapride (Propulsid) Gastric prokinetic (GERD) IKr blocker (modest QT effect) CYP 3A4 substrate Clarithromycin - 3X increase in conc Ketoconazole - 8X increase in conc

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