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Tacrine as related to Alzheimer's Disease


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AD; Alzheimer disease; Alzheimer//'s disease; Alzheimer///'s disease; DAT - Dementia Alzheimer's type; familial Alzheime... 

Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor (anticholinesterase). It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease, and was first synthesised at the Department of Pharmacology at the University of Sydney.

Alzheimer’s disease (AD) is a progressive, neurodegenerative disease characterized in the brain by abnormal clumps (amyloid plaques) and tangled bundles of fibers (neurofibrillary tangles) composed of misplaced proteins. Age is the most important risk factor for AD; the number of people with the disease doubles every 5 years beyond age 65. Three genes have been discovered that cause early onset (familial) AD. Other genetic mutations that cause excessive accumulation of amyloid protein are associ...


Tacrine as related to Alzheimer's Disease


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September 5, 2008


Page Updated: June 12, 2007
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