Not Signed In -
Chemotherapy |
Cancer Chemotherapy |
Clinical Trial: Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia
This study is currently recruiting patients.
Purpose
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which regimen of chemotherapy is more effective for acute lymphoblastic leukemia.
PURPOSE: This randomized phase III trial is comparing four regimens of combination chemotherapy to see how well they work in treating children with newly diagnosed acute lymphoblastic leukemia.
| Condition | Treatment or Intervention | Phase |
|---|---|---|
| untreated childhood acute lymphoblastic leukemia | Drug: cyclophosphamide Drug: cytarabine Drug: daunorubicin Drug: dexamethasone Drug: leucovorin calcium Drug: mercaptopurine Drug: methotrexate Drug: pegaspargase Drug: thioguanine Drug: vincristine Procedure: chemotherapy | Phase III |
MedlinePlus related topics: Leukemia, Adult Acute; Leukemia, Adult Chronic; Leukemia, Childhood
Study Type: Interventional
Study Design: Treatment
Official Title: Phase III Randomized Study of Multidrug Delayed-Intensification Therapy in Children With Newly Diagnosed Standard-Risk Acute Lymphocytic Leukemia: An ALinC #17 Study
Further Study Details:
OBJECTIVES:
- Determine if multidrug delayed-intensification therapy improves outcome in children with newly diagnosed standard-risk acute lymphocytic leukemia.
- Compare the efficacy and toxicity of methotrexate administered over 4 hours vs methotrexate administered over 24 hours in this patient population.
- Determine the correlation between event-free survival, minimal residual disease, and early response in this patient population treated with this multiple drug regimen.
OUTLINE: This is a randomized, multicenter study.
- Induction (weeks 1-4): Patients receive induction therapy on POG 9900.
- Patients are randomized to one of four treatment arms. Patients with t(1;19) are randomized to either arm III or arm IV.
- Arm I (weeks 5-24): Patients receive IT methotrexate (MTX) on day 1 followed by MTX IV over 20 minutes followed by MTX continuously over 23.6 hours on weeks 7, 10, 13, 16,19, and 22. At 42 hours after the beginning of the MTX infusion, patients receive oral leucovorin calcium every 6 hours for a total of 3 doses. Patients also receive oral mercaptopurine daily beginning on week 5 and continuing until the completion of consolidation therapy; oral dexamethasone twice daily on days 1-7 of weeks 8 and 17; and vincristine IV on day 1 of weeks 8, 9, 17, and 18.
- Arm II (weeks 5-24): Patients receive MTX IV over 4 hours on weeks 7, 10, 13, 16, 19, and 22. At 42 hours after the beginning of the MTX infusion, patients receive oral leucovorin calcium as in arm I. Patients also receive mercaptopurine, dexamethasone, vincristine, and IT MTX as in arm I.
- Arm III (weeks 5-32): Patients receive MTX IV as in arm I on weeks 7, 10, 13, 24, 27, and 30; leucovorin calcium as in arm I; pegaspargase IM on day 2, 3, OR 4 of week 16; and oral mercaptopurine daily on weeks 5-13, and from week 24 until the completion of consolidation therapy. Patients also receive IT MTX as in arm I on weeks 7, 10, 13, 16, 20, 21, and 30; oral dexamethasone twice daily on weeks 8, 16-18, and 28 for a total of 35 days; vincristine IV on day 1 of weeks 8, 9, 16, 17, 18, 28, and 29; daunorubicin IV on day 1 of weeks 16-18; cyclophosphamide IV over 30 minutes on day 1 of week 20; cytarabine IV or subcutaneously daily on days 2-5 of weeks 20 and 21; and oral thioguanine daily on weeks 20-21.
- Arm IV (weeks 5-32): Patients receive MTX IV as in arm II on weeks 7, 10, 13, 24, 27, and 30; leucovorin calcium as in arm I; and pegaspargase, mercaptopurine, IT MTX, dexamethasone, vincristine, daunorubicin, cyclophosphamide, cytarabine, and thioguanine as in arm III.
- Intensive continuation (weeks 25-80): At weeks 25-72 for arms I and II, and at weeks 33-80 for arms III and IV, patients receive oral MTX every 6 hours for 4 doses on weeks 1, 3, 5, 7, 9, and 11; oral mercaptopurine daily; oral leucovorin calcium every 12 hours for 2 doses beginning 48 hours after the start of MTX; IT MTX and vincristine IV on day 1 of week 12; and oral dexamethasone twice daily on days 1-7, beginning with the administration of vincristine. Treatment repeats every 12 weeks for 4 courses.
- Additional continuation (weeks 73-130): At weeks 73-130 for arms I and II, and at weeks 81-130 for arms III and IV, patients receive oral MTX weekly; oral mercaptopurine daily; vincristine IV on day 1 every 12 weeks; oral dexamethasone as during intensive continuation therapy; and IT MTX on day 1 every 12 weeks, beginning with the last week of the first course (in place of oral MTX). Patients are followed monthly for 1 year, every 2 months for 1 year, every 3 months for 1 year, every 6 months for 1 year, and then every 6-12 months for 1 year.
PROJECTED ACCRUAL: A total of 1,014 patients will be accrued for this study within 3.22 years.
Eligibility
Ages Eligible for Study: 1 Year - 21 Years, Genders Eligible for Study: Both
Criteria
DISEASE CHARACTERISTICS:
- Confirmed diagnosis of newly diagnosed B-precursor acute lymphocytic leukemia
- Standard risk (not low, high, or very high risk)
- Prior registration and treatment on POG 9900 Classification Study
PATIENT CHARACTERISTICS: Age:
- 1 to 21 at diagnosis
Performance status:
- Not specified
Life expectancy:
- Not specified
Hematopoietic:
- Not specified
Hepatic:
- Not specified
Renal:
- Not specified
Other:
- Not pregnant or nursing
- Fertile patients must use effective contraception
PRIOR CONCURRENT THERAPY: Biologic therapy
- Not specified
Chemotherapy
- Not specified
Endocrine therapy
- Not specified
Radiotherapy
- Not specified
Surgery
- Not specified
Location and Contact Information
Alabama
University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama, 35233, United States; Recruiting
Robert P. Castleberry, MD 205-939-9285 rcastleberry@peds.uab.edu
University of South Alabama Cancer Research Institute, Mobile, Alabama, 36604, United States; Recruiting
Felicia L. Wilson, MD 251-405-5115 fwilson@usouthal.edu
Arizona
Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson, Arizona, 85724, United States; Recruiting
Rochelle Bagatell, MD 520-626-4851
Arkansas
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, United States; Recruiting
David L. Becton, MD 501-320-5650
California
Children's Hospital and Health Center, San Diego, San Diego, California, 92123-4282, United States; Recruiting
Richard Kadota, MD 858-966-5811
Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California, 95051-5386, United States; Recruiting
Carolyn Lucille Russo, MD 408-236-5028 carolyn.l.russo@kp.org
Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego, San Diego, California, 92120, United States; Recruiting
Wellington Loh, MD 619-516-6144
Rebecca and John Moores UCSD Cancer Center, La Jolla, California, 92093-0658, United States; Recruiting
Richard Kadota, MD 858-657-7020
Stanford Cancer Center at Stanford University Medical Center, Palo Alto, California, 94304-1812, United States; Recruiting
Michael P. Link, MD 650-723-5535
Sutter Cancer Center, Sacramento, California, 95816, United States; Recruiting
Yisheng Lee, MD, PhD, MBA 916-733-1757
University of California Davis Cancer Center, Sacramento, California, 95817, United States; Recruiting
Theodore Zwerdling, MD 916-734-2781 theodore.zwerding@ucdmc.ucdavis.edu
Connecticut
Yale Comprehensive Cancer Center, New Haven, Connecticut, 06520-8064, United States; Recruiting
Jack van Hoff, MD 203-785-4640 jack.vanhoff@yale.edu
Florida
All Children's Hospital, St. Petersburg, Florida, 33701, United States; Recruiting
Jerry L. Barbosa, MD 727-892-4231 barbosaj@allkids.org
Baptist-South Miami Regional Cancer Program, Miami, Florida, 33176-2197, United States; Recruiting
Doured Daghistani, MD 786-596-1960
Broward General Medical Center, Fort Lauderdale, Florida, 33316, United States; Recruiting
Rudolph R. Roskos, MD 954-355-4527 rroskos@nbhd.org
Children's Hospital of Southwest Florida, Fort Myers, Florida, 33908, United States; Recruiting
Emad K. Salman, MD 239-432-3333 emad.salman@leememorial.org
Florida Hospital Cancer Institute, Orlando, Florida, 32804, United States; Recruiting
Jane Crofton, RN, BSN, OCN 407-303-2090
Joe DiMaggio Children's Hospital at Memorial, Hollywood, Florida, 33021, United States; Recruiting
Iftikhar Hanif, MD 954-986-2234 ifhanif@aol.com
Miami Children's Hospital, Miami, Florida, 33155, United States; Recruiting
Enrique A. Escalon, MD 305-666-6511
Nemours Children's Clinic, Jacksonville, Florida, 32207, United States; Recruiting
Eric Sandler, MD 904-390-3793 esandler@nemours.org
Nemours Children's Clinic-Orlando, Orlando, Florida, 32806, United States; Recruiting
Vincent F. Giusti, MD 407-650-7230
Sacred Heart Children's Hospital, Pensacola, Florida, 32504, United States; Recruiting
John F. Kelleher, MD 850-505-4798 jfkelleh@neumous.org
St. Joseph's Children's Hospital, Tampa, Florida, 33677-4227, United States; Recruiting
Cameron K. Tebbi, MD 813-870-4252 cameron.tebbi@baycare.org
St. Mary's Hospital, West Palm Beach, Florida, 33407, United States; Recruiting
Narayana Gowda, MD 561-840-6125 doctorgowda@hotmail.com
University of Florida Shands Cancer Center, Gainesville, Florida, 32610-0296, United States; Recruiting
Stephen P. Hunger, MD 352-392-5633 hungersp@peds.ufl.edu
University of Miami Sylvester Comprehensive Cancer Center, Miami, Florida, 30101, United States; Recruiting
Stuart R. Toledano, MD 305-585-5635 stoledan@med.miami.edu
Georgia
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus, Atlanta, Georgia, 30342, United States; Recruiting
Howard M. Katzenstein, MD 404-785-0853 howard.katzenstein@choa.org
MBCCOP-Medical College of Georgia Cancer Center, Augusta, Georgia, 30912-4000, United States; Recruiting
Roger A. Vega, MD 706-721-3626
Hawaii
Cancer Research Center of Hawaii, Honolulu, Hawaii, 96813, United States; Recruiting
Robert Warren Wilkinson, MD 808-586-2979
Tripler Army Medical Center, Honolulu, Hawaii, 96859-5000, United States; Recruiting
Braden Alan Shoupe, MD 808-433-6057
Illinois
Advocate Hope Children's Hospital, Oak Lawn, Illinois, 60453, United States; Recruiting
Sharad N. Salvi, MD 708-346-4094 sharad.salvi@advocatehealth.com
Children's Memorial Hospital - Chicago, Chicago, Illinois, 60614, United States; Recruiting
Susan Lerner Cohn, MD 773-880-4562
Rush University Medical Center, Chicago, Illinois, 60612, United States; Recruiting
Allen D. Korenblit, MD 312-942-5983 akorenbl@rush.edu
Saint Jude Midwest Affiliate, Peoria, Illinois, 61637, United States; Recruiting
John A. McCallister, MD 309-624-4945 john.mccallister@stjude.org
Kansas
CCOP - Wichita, Wichita, Kansas, 67214-3882, United States; Recruiting
David Rosen, MD 316-268-5784
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center, Kansas City, Kansas, 66160-7357, United States; Recruiting
Robert C. Trueworthy, MD 913-588-6340 rtruewor@kumc.edu
Via Christi Cancer Center at Via Christi Regional Medical Center, Wichita, Kansas, 67214, United States; Recruiting
David Rosen, MD 316-268-5000
Wesley Medical Center, Wichita, Kansas, 67214, United States; Recruiting
David Rosen, MD 316-962-2025
Louisiana
Children's Hospital of New Orleans, New Orleans, Louisiana, 70118, United States; Recruiting
Lolie Chua Yu, MD 504-896-9740
MBCCOP - LSU Health Sciences Center, New Orleans, Louisiana, 70112, United States; Recruiting
Jill Gilbert, MD 504-568-5613 jgilbe@lsuhsc.edu
Ochsner Cancer Institute at Ochsner Clinic Foundation, New Orleans, Louisiana, 70121, United States; Recruiting
Marquis Zimri Hodes, MD, PhD 504-842-5230
Tulane Cancer Center at Tulane University Hospital and Clinic, New Orleans, Louisiana, 70112, United States; Recruiting
Marshall A. Schorin, MD 504-988-5412 mschori@tulane.edu
Maine
CancerCare of Maine at Eastern Maine Medial Center, Bangor, Maine, 04401, United States; Recruiting
Judith B. Allen, MD 207-973-7520
Maine Children's Cancer Program, Scarborough, Maine, 04074-9308, United States; Recruiting
Craig A. Hurwitz, MD 207-885-7565 hurwic@mmc.org
Maryland
Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore, Maryland, 21201-1595, United States; Recruiting
Neil Jeffrey Grossman, MD 410-328-2808 ngrossma@peds.umaryland.edu
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, 21231-2410, United States; Recruiting
Cindy Schwartz, MD 410-955-7385 schwac@ijhmi.edu
Walter Reed Army Medical Center, Silver Spring, Maryland, 20910, United States; Recruiting
Kip R. Hartman, MD 301-319-9116
Massachusetts
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston, Massachusetts, 02115, United States; Recruiting
Holcombe Edwin Grier, MD 617-632-3971 holcombe-grier@dfci.harvard.edu
Floating Hospital for Children, Boston, Massachusetts, 02111, United States; Recruiting
Cynthia S. Kretschmar, MD 617-636-5535 ckretschmar@tufts-nemc.org
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, 02114-2696, United States; Recruiting
Howard J. Weinstein, MD 617-724-3315 weinstein.howard@mgh.harvard.edu
UMASS Memorial Cancer Center - University Campus, Worcester, Massachusetts, 01655, United States; Recruiting
Ghazala Naheed Usmani, MD 508-856-4225 usmanin@ummhc.org
Michigan
Children's Hospital of Michigan, Detroit, Michigan, 48201, United States; Recruiting
Yaddanapudi Ravindranath, MBBS 313-745-5649 ravi@med.wayne.edu
Hurley Medical Center, Flint, Michigan, 48503, United States; Recruiting
Susumu Inoue, MD 810-762-7303 sinoue1@hurleymc.com
Van Elslander Cancer Center at St. John Hospital and Medical Center, Detroit, Michigan, 48236, United States; Recruiting
Hadi Sawaf, MD 313-647-3200 hadi.sawaf@stjohn.org
Mississippi
Keesler Medical Center - Keesler Air Force Base, Keesler AFB, Mississippi, 39534-2511, United States; Recruiting
Wanda L. Salzer, MD 228-377-6524
University of Mississippi Medical Center, Jackson, Mississippi, 39216-4505, United States; Recruiting
Dale Jeanette Pullen, MD 601-984-5220
Missouri
Cardinal Glennon Children's Hospital, Saint Louis, Missouri, 63104, United States; Recruiting
William Shay Ferguson, MD 314-577-5638
St. Louis Children's Hospital, Saint Louis, Missouri, 63110, United States; Recruiting
Robert James Hayashi, MD 314-454-4118 hayashi_r@kids.wustl.edu
University of Missouri - Columbia, Columbia, Missouri, 65203, United States; Recruiting
Barbara Anne Gruner, MD 573-882-3961 grunerb@health.missousri.edu
New Hampshire
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, 03756, United States; Recruiting
Eric Christian Larsen, MD 603-650-5541 eric.c.larsen@hitchcock.org
New Jersey
Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey, 07601, United States; Recruiting
Michael B. Harris, MD 201-996-5437 mbharris@humed.com
New Mexico
University of New Mexico Cancer Research and Treatment Center, Albuquerque, New Mexico, 87131, United States; Recruiting
Jami Frost, MD 505-272-4461
New York
Beth Israel Medical Center - Singer Division, New York, New York, 10128, United States; Recruiting
Jeffrey C. Allen, MD 212-870-9407
James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester, New York, 14642, United States; Recruiting
Barbara Lawrence Asselin, MD 716-275-2981
Long Island Cancer Center at Stony Brook University Hospital, Stony Brook, New York, 11794, United States; Recruiting
Robert Ingalls Parker, DSc 631-444-4000
Mount Sinai School of Medicine, New York, New York, 10029, United States; Recruiting
Elizabeth Raetz, MD 212-241-7022
Roswell Park Cancer Institute, Buffalo, New York, 14263-0001, United States; Recruiting
Martin L. Brecher, MD 716-845-2333 martin.brecher@roswellpark.org
Schneider Children's Hospital, New Hyde Park, New York, 11042, United States; Recruiting
Arlene Sara Redner, MD 718-470-3460
SUNY Upstate Medical University Hospital, Syracuse, New York, 13210, United States; Recruiting
Ronald L. Dubowy, MD 315-464-5294 dubowyr@upstate.edu
North Carolina
Blumenthal Cancer Center at Carolinas Medical Center, Charlotte, North Carolina, 28232-2861, United States; Recruiting
Daniel P. McMahon, MD 704-355-1130 dmcmahon@carolinas.org
Comprehensive Cancer Center at Wake Forest University, Winston Salem, North Carolina, 27157-1081, United States; Recruiting
Thomas Williams McLean, MD 336-716-4324
Duke Comprehensive Cancer Center, Durham, North Carolina, 27710, United States; Recruiting
Philip Paul Breitfeld, MD 919-684-3377
Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital, Greenville, North Carolina, 27858-4354, United States; Recruiting
Charles W. Daeschner, MD 252-744-4676 DaeschnerC@mail.ecu.edu
Mission Hospitals, Asheville, North Carolina, 28801, United States; Recruiting
Orren Beaty, DO, PhD 823-213-5770 orren.beaty@msj.org
Presbyterian Cancer Center at Presbyterian Hospital, Charlotte, North Carolina, 28233, United States; Recruiting
Mark Mogul, MD 704-384-1900
Oklahoma
Natalie Warren Bryant Cancer Center at St. Francis Hospital, Tulsa, Oklahoma, 74136, United States; Recruiting
Martina Christine Hum, MD 918-494-2525 pedonc@saintfrancis.com
Oklahoma University Medical Center, Oklahoma City, Oklahoma, 73104, United States; Recruiting
William H. Meyer, MD 405-271-4412 william-meyer@ouhsc.edu
Oregon
CCOP - Columbia River Oncology Program, Portland, Oregon, 97225, United States; Recruiting
Keith S. Lanier, MD 503-216-6260
Legacy Emanuel Hospital and Health Center & Children's Hospital, Portland, Oregon, 97227, United States; Recruiting
Janice Faye Olson, MD 503-413-2200
Pennsylvania
St. Christopher's Hospital for Children, Philadelphia, Pennsylvania, 19134-1095, United States; Recruiting
Gregory E. Halligan, MD 215-427-5000 Gregory.Halligan@tenethealth.com
Rhode Island
Rhode Island Hospital, Providence, Rhode Island, 02903, United States; Recruiting
Sam W. Lew, MD 401-444-5171
South Carolina
Children's Hospital of Greenville Hospital System, Greenville, South Carolina, 29605, United States; Recruiting
Cary Ernest Stroud, MD 864-455-8898
Hollings Cancer Center at Medical University of South Carolina, Charleston, South Carolina, 29425-0721, United States; Recruiting
Julio C. Barredo, MD 843-792-2957 barredjc@musc.edu
Tennessee
East Tennessee State University Cancer Center at Johnson City Medical Center, Johnson City, Tennessee, 37614-0622, United States; Recruiting
David K. Kalwinsky, MD 423-433-6200 sjcrhta@msha,cin
St. Jude Children's Research Hospital, Memphis, Tennessee, 38105-2794, United States; Recruiting
Ching-Hon Pui, MD 901-495-3335
Texas
CCOP - Scott and White Hospital, Temple, Texas, 76508, United States; Recruiting
Lucas Wong, MD 254-724-1053 lwong@swmail.sw.org
Center for Cancer Prevention and Care at Scott and White Clinic, Temple, Texas, 76508, United States; Recruiting
Dick Suh, MD, PhD 254-724-9852 DSuh@swmail.sw.org
Cook Children's Medical Center - Fort Worth, Fort Worth, Texas, 76104, United States; Recruiting
Timothy C. Griffin, MD 682-885-4020 TGriffin@cookchildrens.org
Driscoll Children's Hospital, Corpus Christi, Texas, 78466, United States; Recruiting
Judith K. Mullins, MD 361-694-5311 judith.mullins@dchstx.org
MBCCOP - South Texas Pediatrics, San Antonio, Texas, 78229-3900, United States; Recruiting
Anne-Marie Langevin, MD 210-704-3405 langevin@uthscsa.edu
Medical City Dallas Hospital, Dallas, Texas, 75230, United States; Recruiting
Carl Lenarsky, MD 972-566-6647 carl.lenarsky@usoncology.com
San Antonio Military Pediatric Cancer and Blood Disorders Center, Lackland Air Force Base, Texas, 78236, United States; Recruiting
Aaron Pitney, MD 210-292-5684
Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas, Dallas, Texas, 75390-9063, United States; Recruiting
Naomi J. Winick, MD 214-648-3074 naomi.winick@utsouthwestern.edu
Texas Children's Cancer Center and Hematology Service at Texas Children's Hospital, Houston, Texas, 77030-2399, United States; Recruiting
C. Philip Steuber, MD 832-822-4200 psteuber@tcccc.org
University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78207, United States; Recruiting
Paul Jan Thomas, MD 210-704-3405 thomasp@uthscsa.edu
University of Texas Medical Branch, Galveston, Texas, 77555-0209, United States; Recruiting
Frederick Szujuei Huang, MD 409-772-2341 fshuang@utmb.edu
Vermont
Vermont Cancer Center at University of Vermont, Burlington, Vermont, 05401-3498, United States; Recruiting
Alan C. Homans, MD 802-847-2850
Virginia
Cancer Center at the University of Virginia, Charlottesville, Virginia, 22908, United States; Recruiting
Kimberly Dunsmore, MD 434-924-9333
Carilion Medical Center for Children at Roanoke Community Hospital, Roanoke, Virginia, 24029, United States; Recruiting
Joan Mistretta Fisher, MD, PhD 540-985-8055 jmfisher@carilion.com
INOVA Fairfax Hospital, Falls Church, Virginia, 22042-3300, United States; Recruiting
Jay N. Greenberg, MD 703-698-1110
Massey Cancer Center at Virginia Commonwealth University, Richmond, Virginia, 23298-0121, United States; Recruiting
Nancy L. Dunn, MD 804-828-9605 nldunn@hsc.vcu.edu
Naval Medical Center, Portsmouth, Portsmouth, Virginia, 23708-5100, United States; Recruiting
Paulette Charese Bryant, MD 804-398-5767
Washington
Madigan Army Medical Center, Tacoma, Washington, 98431-0001, United States; Recruiting
Kelly Faucette, MD 253-968-1305 kelly.faucette@nw.amedd.army.mil
West Virginia
Mary Babb Randolph Cancer Center at West Virginia University Hospitals, Morgantown, West Virginia, 26506-9300, United States; Recruiting
Frank G. Keller, MD 304-293-1217
West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division, Charleston, West Virginia, 25302, United States; Recruiting
Elizabeth M. Kurczynski, MD 304-388-1540 ekurczynski@hsc.wvu.edu
Wisconsin
CCOP - Marshfield Clinic Research Foundation, Marshfield, Wisconsin, 54449, United States; Recruiting
Tarit Kumar Banerjee, MD, FACP 715-387-5511
Midwest Children's Cancer Center, Milwaukee, Wisconsin, 53226, United States; Recruiting
Bruce M. Camitta, MD 414-456-4106
St. Vincent Hospital, Green Bay, Wisconsin, 54307-9070, United States; Recruiting
Jon Brandt, MD 920-433-8670
Australia, New South Wales
Children's Hospital at Westmead, Westmead, New South Wales, 2145, Australia; Recruiting
Geoffrey McCowage, MD 61-2-9845-2122
Australia, Queensland
Royal Children's Hospital, Brisbane, Queensland, 4029, Australia; Recruiting
Helen Irving, MBBS 61-7-3636-8111
Australia, Victoria
Royal Children's Hospital, Parkville, Victoria, 3052, Australia; Recruiting
David Ashley, MBBS, FRACP, PhD 61-39-345-5522
Canada, Alberta
Alberta Children's Hospital, Calgary, Alberta, T2T 5C7, Canada; Recruiting
Douglas R. Strother, MD 403-943-7272
Cross Cancer Institute, Edmonton, Alberta, T6G 1Z2, Canada; Recruiting
Paul Edward Grundy, MD 780-432-8894 pgrundy@cha.ab.ca
Canada, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario, K1H 8L1, Canada; Recruiting
Jacqueline Halton, MD 613-737-7600 ext. 2370
Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada; Recruiting
Alberto S. Pappo, MD 416-813-6594 alberto.pappo@sickkids.ca
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario, L8N 3Z5, Canada; Recruiting
Ronald D. Barr, MD 905-521-2100 ext. 73464 rbarr@mcmaster.ca
Canada, Quebec
Centre de Recherche du Centre Hospitalier de l'Universite Laval, Sainte-Foy, Quebec, GIV 4G2, Canada; Recruiting
Yvan Samson, MD 418-656-4141
Hopital Sainte Justine, Montreal, Quebec, H3T 1C5, Canada; Recruiting
Albert Moghrabi, MD 514-345-4969 albert.moghrabi@umontreal.ca
Montreal Children's Hospital at McGill University Health Center, Montreal, Quebec, H3G 1A4, Canada; Recruiting
Carolyn R. Freeman, MB, BS, FRCPC 514-412-8040 carolyn.freeman@muhc.mcgill.ca
Netherlands
University Medical Center Groningen, Groningen, 9700 RB, Netherlands; Recruiting
Willem A. Kamps, MD, PhD 31-50-361-4213 w.a.kamps@bkk.azg.nl
Puerto Rico
San Jorge Children's Hospital, Santurce, 00912, Puerto Rico; Recruiting
Luis Antonio Clavell, MD 787-726-0316 luis.clavell@paviahealth.com
Switzerland
Swiss Pediatric Oncology Group Bern, Bern, CH 3010, Switzerland; Recruiting
Annette Ridolfi-Luethy, MD 41-31-632-9372
Swiss Pediatric Oncology Group Geneva, Geneva, CH 1211, Switzerland; Recruiting
Pierre Wacker, MD 41-22-382-3311
Study chairs or principal investigators
Naomi J. Winick, MD, Study Chair, Simmons Cancer Center
More Information
Clinical trial summary from the National Cancer Institute's PDQ® database
Study ID Numbers: CDR0000067704; COG-P9905; POG-9905; NCT00005596
Record last reviewed: October 2003
Last Updated: April 4, 2005
Record first received: May 2, 2000
ClinicalTrials.gov Identifier: NCT00005596
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Record last reviewed: October 2003
Last Updated: April 4, 2005
Record first received: May 2, 2000
ClinicalTrials.gov Identifier: NCT00005596
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 8, 2005
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