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Dementia |
Senility |
Clinical Trial: Brain Tissue Collection for Neuropathological Studies
This study is currently recruiting patients.
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Purpose
The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders. Information gained from donated tissue may lead to better treatments and potential cures for nervous system and mental disorders.
This study will ask relatives of deceased individuals to donate the brains of their deceased relatives to allow further study of neurological and psychiatric disorders.
| Condition |
|---|
| Bipolar Disorder Huntington Disease Schizophrenia Tourette Syndrome Dementia |
MedlinePlus related topics: Bipolar Disorder; Dementia; Huntington's Disease; Schizophrenia; Tourette Syndrome
Genetics Home Reference related topics: Huntington disease
Study Type: Observational
Study Design: Natural History
Official Title: Brain Procurement for the Neuropathology Section, CBDB
Expected Total Enrollment: 1500
Study start: May 29, 1990
The knowledge of how affected tissue deviates from normal control tissue is an integral part of fully understanding a neurological or psychiatric disorder. The purpose of this protocol is to establish a coordinating program with the pathology departments of the Washington, D.C. and metropolitan area hospitals and local medical examiner's offices for the donation of brain tissue.
Eligibility
Genders Eligible for Study: Both
Accepts Healthy Volunteers
Criteria
Individuals suffering from a variety of neuropsychiatric disorders, especially schizophrenia, but also Huntington's chorea, suicide, manic-depressive illness, depression, Tourette's Syndrome, drug addictions (PCP, cocaine, alcohol, heroin or the like) and any form of dementia.
Brain tissue from afflicted individuals is needed for the study.
Brains (fresh or preserved tissue) from normal individuals without a history of neuropsychiatric disease.
Location and Contact Information
Maryland
National Institute of Mental Health (NIMH), 9000 Rockville Pike, Bethesda, Maryland, 20892, United States; Recruiting
More Information
Detailed Web Page
Publications
Ohuoha DC, Knable MB, Wolf SS, Kleinman JE, Hyde TM. The subnuclear distribution of 5-HT3 receptors in the human nucleus of the solitary tract and other structures of the caudal medulla. Brain Res. 1994 Feb 21;637(1-2):222-6.
Hitri A, Casanova MF, Kleinman JE, Wyatt RJ. Fewer dopamine transporter receptors in the prefrontal cortex of cocaine users. Am J Psychiatry. 1994 Jul;151(7):1074-6.
Wolf SS, Hyde TM, Moody TW, Saunders RC, Weinberger DR, Kleinman JE. Autoradiographic characterization of 125I-neurotensin binding sites in human entorhinal cortex. Brain Res Bull. 1994;35(4):353-8.
Record last reviewed: May 28, 2004
Last Updated: April 6, 2005
Record first received: November 3, 1999
ClinicalTrials.gov Identifier: NCT00001260
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 8, 2005
Resources
- 2001-2002 Alzheimer’s Disease Progress Report (Alzheimer's Disease Education and Referral Center, NIA, NIH, HHS)
- AIDS - Neurological Complications (National Institute of Neurological Disorders and Stroke)
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