Patients with different types of dementia will be recruited and evaluated in national hospital departments for their usual neurological follow-up. A blood sample will be proposed in the field of this research project, and the biological material will be stored at the DNA and Cell bank of IFR of Neurosciences (Pitié-Salpêtrière Hospital, Paris). The clinical research network are already set up for Amzheimer’s disease and frontotemporal dementias, which permits an evaluation according to a clinical standardized protocol.

Among these disorders, a monogenic sub-group has been identified. In Alzheimer’s disease, it is associated with the APP, PSEN1 and PSEN2 genes, which account only for 75% of the familial forms with early onset. In frontotemporal dementias, the tau gene mutations account only for 10% of the cases with an autosomal dominant inheritance. The identification of familial forms with a genetic inquiry in the relatives is essential for a greater knowledge of the molecular bases of forms non caused by the known genes, using linkage approaches and candidate gene analysis. The familial forms are also useful for identifying the modifier genes.

In the multifactorial forms, the aim is to assemble a wide cohort of patients and controls matched for localizing and identifying susceptibility genetic factors. The strategies will used a candidate gene approach, and in the near future, studies of SNPs spread out in the whole genome. Meanwhile, similar approaches, particularly with candidate genes, could be used for identifying predictive factors of tolerance and response to the treatment.

Finally, correlations will be performed with seric markers according to each kind of dementia.

Specialized clinical teams in diagnosis and follow-up in dementias are assembled for this project, and specialized teams in the study of neurological disorders of genetic origin.

Condition	Phase
Alzheimer''''s Disease Dementia Related disorders	Phase I

Further Study Details: 

Expected Total Enrollment:  4000

Ages Eligible for Study:  18 Years   -   90 Years,  Genders Eligible for Study:  Both

Accepts Healthy Volunteers

Criteria

Inclusion Criteria:

- patients presenting a neurodegenerative disorder with cognitive impairment controls (without signs of the disease, matched with sex and age with the patients, relatives for the familial cases

Exclusion Criteria:

- Pregnant women, minors, persons refusing to sign the informed consent

Please refer to this study by ClinicalTrials.gov identifier  NCT00149175

Alexis Brice, MD      0033142162182    brice@ccr.jussieu.fr

France
      Centre Hospitalier, Saint-Brieuc,  22000,  France; Recruiting
      CHU de la Côte de Nacre, Caen,  14000,  France; Recruiting
      Hôpital Bellevue, Saint-Etienne,  42000,  France; Recruiting
      Hôpital Charles Nicolle, Rouen,  76000,  France; Recruiting
      Hôpital Civil, Strasbourg,  67000,  France; Recruiting
      Hôpital de l''''Archet, Nice,  06000,  France; Recruiting
      Hôpital Guillaume et René Laennec, Nantes,  44000,  France; Recruiting
      Hôpital Pontchaillou, Rennes,  35000,  France; Recruiting
      Hôpital Sainte-Marguerite, Marseille,  13009,  France; Recruiting
      Pitié-Salpêtrière Hospital - Centre du Langage et de Neuropsychologie, Paris,  75013,  France; Recruiting
      Pitié-Salpêtrière Hospital - Fédération de Neurologie, Paris,  75013,  France; Recruiting
      Pitié-Salpêtrière Hospital, Paris,  75013,  France; Recruiting

Study chairs or principal investigators

Alexis Brice, MD,  Principal Investigator,  Assistance Publique - Hôpitaux de Paris, University Paris 6   

Study ID Numbers:  02-156; 02-346A10
Last Updated:  September 7, 2005
Record first received:  September 6, 2005
ClinicalTrials.gov Identifier:  NCT00149175
Health Authority: France: Ministry of Health
ClinicalTrials.gov processed this record on 2005-09-13