This is an open labeled dose escalating trial in which a total of 32 subjects will receive one of four intranasal rFla-MBP vaccine doses according to the following chart:

Group / N* / rFla-MBP

A / 8/ 25 micrograms

B / 8/ 125 micrograms

C / 8/ 625 micrograms

D / 8/ 1000 micrograms

* minimum of 6 volunteers per group

An interval no less than 60 days following the first dose will separate the first dose of each volunteer group receiving different rFla-MBP doses. All volunteers will receive three immunizations. The first dosing time point is Day 0, the second is Day 14 (+/- 1 day), the third is day 28 (+/- 2 days). Blood and stool specimens will be collected at intervals to examine systemic and mucosal vaccine antigen-specific immune responses. Vaccine safety will be actively monitored during vaccination and for 28 days following the third vaccine dose.

Accepts Healthy Volunteers

Inclusion Criteria:

• Healthy adult
• 70% accuracy on comprehension test
• Availability for required visits and telephone follow up

Exclusion Criteria:

• Pregnancy or breastfeeding
• Chronic health problems
• Abnormalities found on physical examination
• Use of immunosuppressive drugs, such as corticosteroids or chemotherapy
• Positive blood test for HIV-1, HBsAG or HCV
• Abnormalities found on basic laboratory screening
• Prior exposure to Campylobacter
• Current smoker
• Chronic sinusitis or seasonal rhinitis