Not Signed In -
Electric And Magnetic Fields |
Cell Phones; Electromagnetic Fields; EMF |
Clinical Trial: Magnetic Resonance Imaging at Different Levels of Magnetic Intensity
This study is currently recruiting patients.
Purpose
Magnetic resonance imaging (MRI) is a diagnostic tool that creates high quality images of the human body without the use of X-ray (radiation). MRI uses different levels of magnetic fields to create images of the body and organs. Occasionally, researchers will give patients undergoing a MRI an injection of a substance called gadolinium. Gadolinium works by brightening areas of the magnetic resonance image, thereby improving the contrast.
In this study researchers will use magnetic resonance imaging and contrast substances, like gadolinium, on normal volunteers in order to evaluate different aspects of its performance. Information gathered from this study may be used to develop more specific research studies involving MRI.
| Condition |
|---|
| Cardiovascular Disease Healthy |
MedlinePlus related topics: Heart Diseases; Vascular Diseases
Study Type: Observational
Study Design: Natural History
Official Title: Magnetic Resonance at 1.5 and 3 Tesla
Expected Total Enrollment: 600
Study start: November 5, 1996
Technical evaluation of magnetic resonance imaging and spectroscopy will be performed on normal volunteers. These studies may involve the intravenous administration of commercially available MR contrast media. The results will be used to evaluate the performance of various pulse sequences, gradient coils, and rf coils on human subjects and will provide essential ground work for specific patient protocols.
Eligibility
Genders Eligible for Study: Both
Accepts Healthy Volunteers
Criteria
Any normal volunteer between ages 18 and 80 who is capable of giving informed consent.
EXCLUSION CRITERIA:
A subject will be excluded if he/she has a contraindication to MR scanning such as surgery that involved metal clips or wires which might be expected to concentrate radiofrequency fields or cause tissue damage from twisting twisting in a magnetic field. Examples include:
Aneurysm clip;
Implanted neural stimulator;
Implanted cardiac pacemaker or autodefibrillator;
Cochlear implant;
Ocular foreign body (e.g. metal shavings);
Insulin pump.
Subjects will be excluded if it is deemed that they have a condition which would preclude their use for technical development (e.g. paralyzed hemidiaphragm, morbid obesity, claustrophobia, etc.) or present unnecessary risk (e.g. pregnancy, surgery of uncertain type, etc.).
Lactating women and subjects with hemoglobinopathies, asthma, or renal or hepatic disease will be excluded from studies involving the administration of contrast agents.
Location and Contact Information
Maryland
National Heart, Lung and Blood Institute (NHLBI), 9000 Rockville Pike, Bethesda, Maryland, 20892, United States; Recruiting
TTY 1-866-411-1010
More Information
Detailed Web Page
Publications
Mattay VS, Weinberger DR, Barrios FA, Sobering GS, Kotrla KJ, van Gelderen P, Duyn JH, Sexton RH, Moonen CT, Frank JA. Brain mapping with functional MR imaging: comparison of gradient-echo--based exogenous and endogenous contrast techniques. Radiology. 1995 Mar;194(3):687-91.
Niendorf HP, Dinger JC, Haustein J, Cornelius I, Alhassan A, Clauss W. Tolerance data of Gd-DTPA: a review. Eur J Radiol. 1991 Jul-Aug;13(1):15-20. Review.
Frank JA, Mattay VS, Duyn J, Sobering G, Barrios FA, Zigun J, Sexton R, Kwok P, Woo J, Moonen C, et al. Measurement of relative cerebral blood volume changes with visual stimulation by 'double-dose' gadopentetate-dimeglumine-enhanced dynamic magnetic resonance imaging. Invest Radiol. 1994 Jun;29 Suppl 2:S157-60. No abstract available.
Record last reviewed: October 7, 2004
Last Updated: November 23, 2004
Record first received: November 3, 1999
ClinicalTrials.gov Identifier: NCT00001619
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 9, 2005
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