Not Signed In -
Glaucoma |
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Clinical Trial: Relationship Between Topiramate Use and Ocular Angle Status
This study has been completed.
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Purpose
We test the hypothesis whether topiramate narrows the angles which may render Asians more likely to suffer from acute angle closure glaucoma.
| Condition | Intervention | Phase |
|---|---|---|
| Glaucoma, Angle-Closure | Drug: Topiramate | Phase IV |
MedlinePlus related topics: Glaucoma
Study Type: Interventional
Study Design: Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Safety Study
Official Title: Relationship Between Topiramate Use and Ocular Angle Status: A Prospective Pilot Study
Further Study Details:
Primary Outcomes: Change(s) in ophthalmic parameters measured at baseline and after 4 weeks of treatment, including:; - Best-corrected visual acuity; - Refraction; - Goldmann applanation tonometry; - Gonioscopy; - Dilated fundus examination; - Ultrasound biomicroscopy of angle and anterior segment
Expected Total Enrollment: 15
Expected Total Enrollment: 15
Study start: September 2004; Study completion: May 2005
Last follow-up: February 2005; Data entry closure: April 2005
Topiramate is approved for the treatment of epilepsy and prophylaxis of migraine attacks. There were case reports of acute angle closure glaucoma (AACG) associated with its use. AACG is particularly common in Asians because of a higher prevalence of narrow angle., we test the hypothesis whether topiramate narrows the angles which may render them more likely to suffer from AACG.
Eligibility
Ages Eligible for Study: 18 Years - 75 Years, Genders Eligible for Study: Both
Criteria
Inclusion Criteria:
- Participants aged 18-75 with an indication for starting topiramate.
Exclusion Criteria:
- Patients with known allergy or intolerance to topiramate.
- Recent exposure to topiramate (<3 months).
- Moderate to severe renal failure.
- Known history of renal calculi or hepatic failure
- Inability to give informed consent.
- Pregnant women or women of child-bearing age who do not practise an acceptable means of contraception.
- Patients known to have angle-closure glaucoma.
Location Information
Hong Kong
Prince of Wales Hospital, Shatin, Hong Kong
Hong Kong Eye Hospital, Kowloon, Hong Kong
Study chairs or principal investigators
Dexter YL Leung, MRCS, Principal Investigator, Hong Kong Eye Hospital
Howan Leung, MRCP, Principal Investigator, Chinese University of Hong Kong
More Information
Study ID Numbers: CRE-2004.310
Last Updated: September 9, 2005
Record first received: September 8, 2005
ClinicalTrials.gov Identifier: NCT00153699
Health Authority: Hong Kong: Joint CUHK-NTEC Clinical Research Ethics Committee
ClinicalTrials.gov processed this record on 2005-09-13
Last Updated: September 9, 2005
Record first received: September 8, 2005
ClinicalTrials.gov Identifier: NCT00153699
Health Authority: Hong Kong: Joint CUHK-NTEC Clinical Research Ethics Committee
ClinicalTrials.gov processed this record on 2005-09-13
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