Article: Genes and Disease: Lung carcinoma, small cell

Lung carcinoma, small cell

In the US, lung cancer is the most common cause of cancer deaths among both men and women. In fact, North Americans have the highest rates of lung cancer in the world. In 1997, some 178,100 new cases were diagnosed, and roughly 160,400 deaths occurred from the disease. Sadly, the 5-year survival rate for persons with lung cancer is only 14%. Since the 1940s, the increase in lung cancer mortality by gender has followed historic patterns of smoking, with a 20-year time lag. About 90% of male lung cancer deaths and 80% of female lung cancer deaths are attributable to cigarette smoking. Although smoking is by far the major risk factor for lung cancer, certain industrial substances, such as asbestos, and environmental factors can contribute.

Small cell lung carcinoma is distinctive from other kinds of lung cancer (metastases are already present at the time of discovery) and accounts for approximately 110,000 cancer diagnoses annually. A deletion of part of chromosome 3 was first observed in 1982 in small cell lung carcinoma cell lines.

As with other cancers, mutations in a variety of molecules (oncogenes and tumor-suppressor genes) that control cell growth and division are observed, and no one mutation is likely to result in cancerous growth. Basic research into the function of these moleculeshow and when they play their roleshould help the fight against lung, and other, cancers and give clues to find appropriate therapies.