Myasthenia Gravis

Myasthenia gravis (sometimes abbreviated MG; from the Greek myastheneia, lit. 'muscle weakness', and Latin gravis, lit. 'serious') is a neuromuscular disease leading to fluctuating weakness and fatiguability. At about 14 cases per 100,000 (in the U.S.), it is one of the best known autoimmune disorders. The antigens and basic disease mechanisms are known. Weakness is caused by circulating antibodies that block acetylcholine receptors or the MuSK protein at the post-synaptic neuromuscular jun ...