The purpose of this study is to determine whether cognitive behavioral therapy (CBT), administered by a CBT therapist, or instruction on CBT by a child psychiatrist (I-CBT) can decrease obsessive compulsive disorder (OCD) symptoms in children and adolescents who are partial responders to a serotonin reuptake inhibitor (SRI) treatment.

Condition	Treatment or Intervention	Phase
Obsessive Compulsive Disorder	Drug: Serotonin reuptake inhibitors  Behavior: Cognitive Behavioral Therapy	Phase III

Further Study Details: 

Expected Total Enrollment:  150

The vast majority of children with OCD are given SRI drugs as initial treatment. However, recommended doses of these medications leave many children with clinically significant residual symptoms. Health care experts typically recommend augmenting SRI treatment with CBT, yet this recommendation is seldom followed. This study will contrast two CBT augmentation strategies, CBT administered by a psychologist and instructional CBT administered by a psychiatrist in the context of ongoing medication management to continued medication management alone.

All patients in the trial will be eligible to receive a full course of CBT by study end. Specifically, participants in this study will be randomly assigned to receive CBT, I-CGT or continued medication management. All participants will continue their SRI treatment for 12 weeks. After the 12-week treatment period, participants who received I-CBT or medication management alone and who remain symptomatic will be given CBT as will participants who are asymptomatic but relapse within 6 months after treatment. Assessments will be conducted at Weeks 0, 4, 8, and 12. Follow-up assessments will be conducted at 3, 6, 9, and 12 months post-treatment.

Ages Eligible for Study:  8 Years   -   17 Years,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

• DSM-IV diagnosis of obsessive compulsive disorder (OCD)
• Have had partial response to serotonin reuptake inhibitor (SRI) pharmacotherapy

North Carolina
      Duke Child and Family Study Center, Durham,  North Carolina,  27705,  United States; Recruiting
Pennsylvania
      University of Pennsylvania The Center for the Treatment and Study of Anxiety, Philadelphia,  Pennsylvania,  19104,  United States; Recruiting
Rhode Island
      Rhode Island Hospital, Providence,  Rhode Island,  02903,  United States; Recruiting

Study ID Numbers:  MH55121-06A2
Record last reviewed:  March 2005
Last Updated:  March 24, 2005
Record first received:  December 19, 2003
ClinicalTrials.gov Identifier:  NCT00074815
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08