Osteogenesis imperfecta is a group of inherited disorders that mainly affect the bones. The term "osteogenesis imperfecta" means imperfect bone formation. The condition causes bones to be fragile and easily broken and is also responsible for other health problems. Genetic changes are related to the following types of osteogenesis imperfecta. osteogenesis imperfecta, type I osteogenesis imperfecta, type II osteogenesis imperfecta, type III osteogenesis imperfecta, type IV Researchers have defined three more types of osteogenesis imperfecta (type V, type VI, and type VII), but the genetic causes have not yet been identified. The signs and symptoms of this condition vary widely. Type I osteogenesis imperfecta is the mildest form of the disorder, while type II is the most severe. All forms of osteogenesis imperfecta include fragile bones and frequent bone fractures. Some types are associated with brittle teeth, hearing loss, a blue or grey tint to the part of the eye that is usually white (the sclera), curvature of the spine (scoliosis), and loose joints. People with osteogenesis imperfecta are often shorter than average.