During one year, 5-8% of the population will suffer from major depression. Some of the key symptoms are loss of interest in daily activities, loss of energy and sleeping disturbances. The financial consequences of this disease is estimated to be more than 30 million pounds per year in Great Britain and USA alone. There is an increasing interest in the effect exercise has on depression. Smaller studies indicate that exercise is a good treatment for depression. This study will be a large scale randomized trial and will hopefully bring important knowledge on the effects exercise has on depression. We will compare the effect endurance training, weight-lifting exercise and a control group has on depressive symptoms after 4 months training, twice a week.

Condition	Treatment or Intervention
Depression	Behavior: Endurance training  Behavior: Weight-lifting training

Further Study Details: 

Primary Outcomes: HAMD-17
Secondary Outcomes: Remission (<8 HAMD-17); Response (50% reduction of score on HAMD-17); Job situation
Expected Total Enrollment:  300

Ages Eligible for Study:  18 Years   -   55 Years,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

• Age: 18-55
• ICD-10 diagnoses F32.0, F32.1, F33.0, F33.1
• Speak fluent danish

Exclusion Criteria:

• Not able to do exercise
• Drug/alcohol addict
• The patient already engages in more than one hour of weekly exercise.
• The patient has not been working the last 24 months due to depression.
• Suicidal behavior.

Denmark
      Psychiatric department, Bispebjerg Hospital, Copenhagen,  2400,  Denmark; Recruiting

Study ID Numbers:  KF01-213/04
Record last reviewed:  February 2005
Last Updated:  February 9, 2005
Record first received:  February 8, 2005
ClinicalTrials.gov Identifier:  NCT00103415
Health Authority: Denmark: National Board of Health (Awaiting confirmation)
ClinicalTrials.gov processed this record on 2005-04-08