Chronic sinusitis is a common pediatric disease; it ranks among the top five infectious diseases of the upper respiratory tract. Its treatment is limited and may be due largely in part to a lack of understanding of its cause. The investigators have preliminary data to support the notion that pediatric chronic sinusitis is a distinct disease, different from acute sinusitis and adult chronic sinusitis. We are proposing to perform pathogenesis studies in children with chronic sinusitis. Specifically, we wish to elucidate the microbiologic features and immunologic factors involved in the formation of this disease. The study plan calls for microbiologic (bacterial, viral, and fungal) and immunologic (inflammatory mediators and leukocyte populations) data to be evaluated through a maxillary sinus washing and mucosal biopsies. Four populations will be studied and they are: 10 children with chronic sinusitis, 5 children with acute sinusitis (positive control), 5 children without sinusitis (negative control) and 5 adults with chronic sinusitis (positive secondary control).

Condition	Treatment or Intervention
Sinusitis	Procedure: pathogenesis study

Ages Eligible for Study:  up to  18 Years,  Genders Eligible for Study:  Both

Accepts Healthy Volunteers

Criteria

Inclusion Criteria:

• chronic sinusitis confirmed by imaging study for greater than 12 weeks subjects have failed medical therapy

Colorado
      The Children's Hospital, Denver,  Colorado,  80218,  United States

Study ID Numbers:  NCRR-M01RR00069-0609; M01RR00069
Record last reviewed:  November 2001
Last Updated:  October 13, 2004
Record first received:  February 23, 2000
ClinicalTrials.gov Identifier:  NCT00004638
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08