Thalomid (thalidomide) is used to treat the debilitating and disfiguring skin inflammation that is sometimes a reaction to erythema nodosum leprosum (ENL), an inflammatory complication of leprosy and to prevent and control its return. When there is inflammation of the nerves in addition to skin sores, Thalomid (thalidomide) should not be used as the only drug treatment. Efficacy in HIV disease has not been proven.