Adults with cyanotic congenital heart disease have elevated levels of plasma proatrial natruretic peptide (proANP) which most likely results in chronic dehydration, leading to reduced oxygen transport to tissues and shortness of breath with activity. The purpose of this study is to characterize adults with cyanotic congenital heart defects with respect to their body composition (water and fat-free mass) and resting metabolic rates. The study consists of several measures of how much body water, fat and lean tissue a subject has, and measures the number of calories the subject's body uses at rest. Adult subjects with cyanotic congenital heart disease will be recruited along with healthy noncyanotic control subjects matched for age, gender, and body weight.

Condition
Heart Defects, Congenital

Ages Eligible for Study:  17 Years   -   60 Years,  Genders Eligible for Study:  Both

Accepts Healthy Volunteers

Criteria

Inclusion Criteria:

• Resting blood pressure below 140/90

Vermont
      University of Vermont, Burlington,  Vermont,  05401,  United States

Study ID Numbers:  NCRR-M01RR00109-0737; M01RR00109
Record last reviewed:  December 2003
Last Updated:  October 13, 2004
Record first received:  January 18, 2000
ClinicalTrials.gov Identifier:  NCT00000107
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08