Magnetic resonance imaging (MRI) and spectroscopy are diagnostic tools that create high quality images of the human body without the use of X-ray (radiation). MRI uses different levels of magnetic fields to create images of the body and organs. Occasionally, researchers will give patients undergoing a MRI an injection of a contrast substance. The contrast substance works by brightening areas of the magnetic resonance image.

In this study researchers plan to use magnetic resonance imaging with contrast substances and exercise on normal volunteers in order to evaluate different aspects of its performance. Information gathered from this study may be used to develop more specific research studies involving MRI.

Condition
Cardiovascular Disease Healthy

Further Study Details: 

Expected Total Enrollment:  400

Technical evaluation of magnetic resonance imaging and spectroscopy will be performed on normal volunteers. These studies will be conducted in the NIH MRI systems located in Suburban Hospital in Bethesda, Maryland. These studies may involve the intravenous administration of commercially available MR contrast media and exercise. The results will be used to evaluate the performance of various pulse sequences, gradient coils, and RF coils on human subjects and will provide essential ground work for specific patient protocols.

Genders Eligible for Study:  Both

Accepts Healthy Volunteers

Criteria

INCLUSION CRITERIA:
Any normal volunteer above the age 18 who is capable of giving informed consent will be included.
EXCLUSION CRITERIA:
A subject will be excluded if he/she has a contradiction to MR scanning such as surgery that involved metal clips or wires which might be expected to concentrate radiofrequency fields or cause tissue damage from twisting in a magnetic field. Examples include:
1) Aneurysm clip;
2) Implanted neural stimulator;
3) Implanted cardiac pacemaker implanted defibrillator;
4) Cochlear implant
5) Ocular foreign body (e.g. metal shavings);
6) Insulin pump.
Subjects will be excluded if it is deemed that they have a condition that would preclude their use of technical development (e.g. paralyzed hemidiaphragm, morbid obesity, claustrophobia etc.) or present unnecessary risk (e.g. pregnancy, surgery of uncertain type, etc.).
Lactating women and subjects with hemoglobinopathies, asthma, or renal or hepatic disease will be excluded from studies involving the adminstration of contrast agents.

Maryland
      National Heart, Lung and Blood Institute (NHLBI), 9000 Rockville Pike,  Bethesda,  Maryland,  20892,  United States; Recruiting

Study ID Numbers:  990048; 99-H-0048
Record last reviewed:  February 3, 2005
Last Updated:  February 23, 2005
Record first received:  November 3, 1999
ClinicalTrials.gov Identifier:  NCT00001874
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08