This clinicl trials try to use tissue fibrin glues (Tissell) to treat various ocular surface diseases or surgerys, which includes pterygium surgery, corneal melting/perforation, Gunderson''''s flap,conjuntical laceration,and muscle/cintical/flitering surgery

Condition	Intervention	Phase
Pterygium Corneal Perforation Corneal Ulcer	Drug: tissue fibrin glue application (Tisseel)	Phase I

Further Study Details: 

Primary Outcomes: cure of the diseases; visual acuity; side effects
Secondary Outcomes: integrity of the ocular surface
Expected Total Enrollment:  30

This clinicl trials try to use tissue fibrin glues (Tissell) to treat various ocular surface diseases or surgerys. The inclusion criteria is (1) ocular surface disease which may need amniotic membrane transplantation (corneal prro epithelization, pterygium surgery, etc)(2) infectious or noninfectious corneal ulcer with perfoation less than 3 mm (3) conjuntical transplantation/suture (4)corneal sugeries which can be treated by conventional suture technique or applcation with cyanoacrylic acid tissue glues.Inform consents will be obtained from the patients before applcatinos. After surgeries, topical steroids and antibiotics will be used, and therapeutic contact lens will be used. The Patients will be followed up for at least three months.

Ages Eligible for Study:  3 Years and above,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

• ocular surface diseases, which are expected to be treated by tissue fibrin glues

Exclusion Criteria:

• preganancy, children younger than 3 years old

Please refer to this study by ClinicalTrials.gov identifier  NCT00155402

Wei-Li Chen      011-886-2-23123456  Ext. 5206    cwlboston@yahoo.com.tw

Taiwan
      Wei-Li Chen, Taiwan,  100,  Taiwan; Recruiting

Study chairs or principal investigators

Fung-Rong Hu, MD,  Principal Investigator,  National Taiwan University Hospital   

Study ID Numbers:  940208
Last Updated:  September 9, 2005
Record first received:  September 8, 2005
ClinicalTrials.gov Identifier:  NCT00155402
Health Authority: Taiwan: Department of Health
ClinicalTrials.gov processed this record on 2005-09-13