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International Micronutrient Malnutrition Prevention & Control Program |
IMMPaCt |
Clinical Trial: Prevention of Depression in At-Risk Adolescents
This study is currently recruiting patients.
|
Purpose
The purpose of this study is to determine the impact of a group cognitive behavioral program (CBP) on the depressive symptoms and disorders of adolescents at risk for developing depression.
| Condition | Treatment or Intervention |
|---|---|
| Depression | Behavior: Cognitive Behavioral Program |
MedlinePlus related topics: Depression
Study Type: Interventional
Study Design: Prevention, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study
Expected Total Enrollment: 320
Study start: August 2003; Expected completion: January 2008
Depression is a prevalent, chronic, and impairing condition that is often undetected and becomes more difficult to treat as chronicity increases. There is an increasing need to develop large-scale depression prevention studies in adolescents. This study will evaluate a cognitive-behavioral prevention program to determine its effectiveness in preventing depression in at-risk adolescents. The study also will ascertain the costs and benefits of incorporating this intervention into "real world" settings.
Participants in this study will be randomly assigned to receive either CBP or usual care for 32 months. Depressive symptoms, levels of functioning, and medical and mental health care utilization will be assessed at baseline and again at 2, 8, 20, and 32 months after intake.
Eligibility
Ages Eligible for Study: 13 Years - 17 Years, Genders Eligible for Study: Both
Criteria
Inclusion Criteria:
- Have a parent with depression
- Past depressive episode or current subsyndromal depressive symptoms
Location and Contact Information
Massachusetts
Harvard University Medical School, Boston, Massachusetts, 02115-5794, United States; Recruiting
William Beardslee, MD, Principal Investigator
Oregon
Kaiser Permanente Center for Health Research, Portland, Oregon, 97227, United States; Recruiting
Greg Clarke, PhD 503-335-6673 greg.clarke@kp.org
Greg Clarke, PhD, Principal Investigator
Pennsylvania
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213-2593, United States; Recruiting
David Brent, MD, Principal Investigator
Tennessee
Vanderbilt University, Nashville, Tennessee, 37203-5721, United States; Recruiting
Judy Garber, PhD, Principal Investigator
More Information
Publications
Clarke GN, Hornbrook M, Lynch F, Polen M, Gale J, Beardslee W, O'Connor E, Seeley J. A randomized trial of a group cognitive intervention for preventing depression in adolescent offspring of depressed parents. Arch Gen Psychiatry. 2001 Dec;58(12):1127-34.
Record last reviewed: March 2005
Last Updated: March 24, 2005
Record first received: December 2, 2003
ClinicalTrials.gov Identifier: NCT00073671
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 9, 2005
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