The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To evaluate: cold water immersion modulates the reinforcing effects of nitrous oxide in healthy volunteers.

Condition	Treatment or Intervention	Phase
Opioid-Related Disorders Substance-Related Disorders	Drug: Nitrous oxide	Phase II

Further Study Details: 

Ages Eligible for Study:  21 Years   -   32 Years,  Genders Eligible for Study:  Both

Criteria

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Illinois
      University of Chicago, Anesthesia & Critical Care, Chicago,  Illinois,  60637,  United States

Study chairs or principal investigators

James Zacny, Ph.D.,  Principal Investigator,  University of Chicago   

Study ID Numbers:  NIDA-08391-2; R01-08391-2
Record last reviewed:  April 1994
Last Updated:  November 18, 2004
Record first received:  September 20, 1999
ClinicalTrials.gov Identifier:  NCT00000250
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08