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Water-Related Injuries |
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Clinical Trial: Risk Factors for Anterior Cruciate Ligament (ACL) Injury
This study is not yet open for patient recruitment.
Verified by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) March 2005
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Purpose
The anterior cruciate ligament (ACL) is located inside the knee joint and provides stability to the knee. ACL injuries occur more frequently in women than men; the reason for this is unknown. The purpose of this study is to determine gender-specific anatomical, hormonal, and demographic risk factors for ACL injury.
Study hypothesis: Human movement factors, including key kinetics and kinematics of the knee during a jump-landing task, are associated with the rate of ACL injury.
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| Knee Injuries Athletic Injuries |
MedlinePlus related topics: Knee Injuries and Disorders; Sports Injuries
Study Type: Observational
Study Design: Screening, Longitudinal, Defined Population, Prospective Study
Official Title: Epidemiology of Jump-Landing Movements and ACL Injury
Expected Total Enrollment: 4800
Study start: June 2005
The ACL stabilizes the knee joint by preventing the shinbone (tibia) from sliding forward beneath the thighbone (femur). A hard twist or excessive pressure on the ACL can tear or rupture the ligament, resulting in high levels of short-term disability and extensive rehabilitation. Previous data indicate that women who participate in sports or who are otherwise physically active have higher rates of ACL injury than men; the reason for this is unknown. There are four groups of potential risk factors for ACL injury: environmental, anatomical, hormonal, and biomechanical or neuromuscular. In particular, poor technique when landing from a jump (also known as jump-landing) is proposed as a specific neuromuscular risk factor of interest in this study. This study will determine gender-specific anatomical, hormonal, and demographic risk factors for ACL injury, as well as quantify gender-specific differences in jump-landing technique and other neuromuscular risk factors.
The study will enroll 4,800 cadets at the three large U.S. military academies; approximately 50% of those enrolled will be women. Each study participant will undergo a baseline assessment that will include measurement of neuromuscular risk factors using motion analysis, strength testing, and standardized assessment of poor jump-landing technique using the Landing Error Score System (LESS). All participants will be followed for up to 4 years. ACL injuries will be prospectively identified; an injury questionnaire is administered to participants who sustain an ACL injury while they are cadets. Otherwise, there is no further contact.
Eligibility
Accepts Healthy Volunteers
Inclusion Criteria:
- Incoming cadet at the U.S. Naval, Air Force, or Military Academies
Location and Contact Information
Colorado
U.S. Air Force Academy, Colorado Springs, Colorado, 80840, United States
Keith Odegard, MD, Sub-Investigator
Maryland
U.S. Naval Academy, Annapolis, Maryland, 21402-5000, United States
Barry Boden, MD, Sub-Investigator
Anthony Beutler, MD, Sub-Investigator
Scott Pyne, MD, Sub-Investigator
New York
U.S. Military Academy, West Point, New York, 10996, United States
Thomas DeBerardino, MD, Sub-Investigator
Bradley Nelson, MD, Sub-Investigator
Dean Taylor, MD, Sub-Investigator
Sally Mountcastle, PhD, Sub-Investigator
Stephen W. Marshall, PhD, Principal Investigator, University of North Carolina
More Information
Publications
Blackburn JT, Riemann BL, Padua DA, Guskiewicz KM. Sex comparison of extensibility, passive, and active stiffness of the knee flexors. Clin Biomech (Bristol, Avon). 2004 Jan;19(1):36-43.
Chappell JD, Yu B, Kirkendall DT, Garrett WE. A comparison of knee kinetics between male and female recreational athletes in stop-jump tasks. Am J Sports Med. 2002 Mar-Apr;30(2):261-7.
Griffin LY, Agel J, Albohm MJ, Arendt EA, Dick RW, Garrett WE, Garrick JG, Hewett TE, Huston L, Ireland ML, Johnson RJ, Kibler WB, Lephart S, Lewis JL, Lindenfeld TN, Mandelbaum BR, Marchak P, Teitz CC, Wojtys EM. Noncontact anterior cruciate ligament injuries: risk factors and prevention strategies. J Am Acad Orthop Surg. 2000 May-Jun;8(3):141-50. Review.
Gwinn DE, Wilckens JH, McDevitt ER, Ross G, Kao TC. The relative incidence of anterior cruciate ligament injury in men and women at the United States Naval Academy. Am J Sports Med. 2000 Jan-Feb;28(1):98-102.
Uhorchak JM, Scoville CR, Williams GN, Arciero RA, St Pierre P, Taylor DC. Risk factors associated with noncontact injury of the anterior cruciate ligament: a prospective four-year evaluation of 859 West Point cadets. Am J Sports Med. 2003 Nov-Dec;31(6):831-42.
Last Updated: August 1, 2005
Record first received: July 26, 2005
ClinicalTrials.gov Identifier: NCT00124319
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-08-02
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