This is a Phase III study in patients with melanoma that has spread to the lymph nodes and/or a distant organ, and who have had all of their cancer surgically removed. The purpose of this study is to evaluate the ability of the CancerVax™ vaccine to prevent or slow the recurrence of melanoma.

Condition	Treatment or Intervention	Phase
Malignant Melanoma	Vaccine: CancerVax vaccine (CANVAXIN)	Phase III

Ages Eligible for Study:  18 Years   -   80 Years,  Genders Eligible for Study:  Both

Criteria

• Must have Stage IV melanoma
• Must have had all clinically-detectable disease surgically removed
• Cannot be taking any medications, or undergoing any therapies which compromise the functioning of your immune system (ie. Some corticosteroids, and certain types of radiation therapy)
• Cannot have HIV or Hepatitis A, B, or C

Arizona
      Arizona Cancer Center, Tucson,  Arizona,  85724,  United States
Arkansas
      Central Arkansas Veterans Healthcare System, Little Rock,  Arkansas,  72205,  United States
      University of Arkansas for Medical Sciences, Little Rock,  Arkansas,  72205,  United States
California
      Kaiser Permanente Medical Group, San Diego,  California,  92120,  United States
      Sharp Hospital, San Diego,  California,  92123,  United States
      Hoag Memorial Hospital Presbyterian, Newport Beach,  California,  92658,  United States
      UCSF Cancer Center and Cancer Research Institute, San Francisco,  California,  94143-0128,  United States
      Comprehensive Cancer Center at DRMC, Palm Springs,  California,  92262,  United States
      Cedars Sinai Comprehensive Cancer Center, Los Angeles,  California,  United States
      Kaiser Permanente Medical Group, Anaheim,  California,  United States
      Kaiser Permanente Medical Group, Riverside,  California,  United States
Colorado
      University of Colorado Cancer Center, Aurora,  Colorado,  United States
Florida
      The Cancer Institute at Good Samaritan Medical Center, West Palm Beach,  Florida,  33401,  United States
      Florida Hospital Cancer Institute, Orlando,  Florida,  32804,  United States
      H. Lee Moffitt Cancer Center and Research Institute, Tampa,  Florida,  33612-9497,  United States
      Lakeland Regional Cancer Center, Lakeland,  Florida,  33805,  United States
      Mt. Sinai Comprehensive Cancer Center, Miami,  Florida,  United States
      University of Miami, Miami,  Florida,  United States
Illinois
      OSF Saint Francis Medica Center, Peoria,  Illinois,  61637,  United States
      Loyola University Medical Center, Maywood,  Illinois,  United States
Indiana
      Wagner and Associates, Indianapolis,  Indiana,  46256,  United States
Kentucky
      James Graham Brown Cancer Center, Louisville,  Kentucky,  40202,  United States
Maryland
      St. Agnes Healthcare, Baltimore,  Maryland,  21229,  United States
      Franklin Square Hospital Center, Baltimore,  Maryland,  21237,  United States
      Sidney Kimmel Comprehensive Cancer Center, Lutherville,  Maryland,  United States
Massachusetts
      Boston Medical Center, Boston,  Massachusetts,  02118-2393,  United States
Michigan
      Spectrum Health - Butterworth Campus, Grand Rapids,  Michigan,  49546,  United States
Missouri
      Ellis Fischel Cancer Center - Columbia, Columbia,  Missouri,  65203,  United States
      St. Louis University Health Sciences Center, Saint Louis,  Missouri,  63110-0250,  United States
New Jersey
      Medical Center of Princeton, Princeton,  New Jersey,  08540,  United States
      The Cancer Cener at Hackensack University Medical Center, Hackensack,  New Jersey,  07601,  United States
New York
      Millard Fillmore Hospital, Buffalo,  New York,  14209,  United States
      Roswell Park Cancer Institute, Buffalo,  New York,  14263-0001,  United States
      Columbia Presbyterian Medical Center, New York,  New York,  10032,  United States
      Suny Health Science Center at Syracuse, Syracuse,  New York,  13210,  United States
North Carolina
      Lineberger Comprehensive Cancer Center, UNC, Chapel Hill,  North Carolina,  27599-7295,  United States
      Wake Forest University, Winston Salem,  North Carolina,  United States
Ohio
      Arthur G. James Cancer Hospital - Ohio State University, Columbus,  Ohio,  43210-1240,  United States
      Christ Hospital, Cincinnati,  Ohio,  45219,  United States
      Dayton Clinical Oncology Group, Dayton,  Ohio,  45409,  United States
      Cleveland Clinic Foundation, Cleveland,  Ohio,  United States
Pennsylvania
      Lankenau Hospital, Wynnewood,  Pennsylvania,  19096,  United States
      University of Pennsylvania Cancer Center, Philadelphia,  Pennsylvania,  19104-4283,  United States
      St. Lukes Hospital Cancer Center, Bethlehem,  Pennsylvania,  18015,  United States
Tennessee
      Vanderbilt-Ingram Cancer Center, Nashville,  Tennessee,  37232-6838,  United States
Texas
      UT Southwest Medical Center- Dallas, Dallas,  Texas,  75235-9154,  United States
      University of Texas - MD Anderson Cancer Center, Houston,  Texas,  77030-4009,  United States
Utah
      Intermountain Health Care- Mckay-Dee Hospital, Ogden,  Utah,  84403,  United States
      Intermountain Health Care-LDS Hospital, Salt Lake City,  Utah,  84143,  United States
Washington
      University of Washington, Seattle,  Washington,  98109,  United States
      Northwest Medical Specialties, Tacoma,  Washington,  98405,  United States
Australia, New South Wales
      NSW Breast Cancer Institute, Westmead,  New South Wales,  2145,  Australia
      Royal Prince Alfred Hospital, Sydney, Sydney,  New South Wales,  2050,  Australia
Australia, Queensland
      Princess Alexandra Hospital, Brisbane,  Queensland,  4102,  Australia
Australia, South Australia
      Royal Adelaide Hospital, Adelaide,  South Australia,  5000,  Australia
Australia, Victoria
      The Alfred Hospital, Melbourne,  Victoria,  3181,  Australia
      Peter MacCallum Cancer Center, Melbourne,  Victoria,  3002,  Australia
Brazil
      INCA (National Cancer Institute), Rio de Janeiro,  20230,  Brazil
      Hospital Sirio Lebanes, Sao Paulo,  01308-050,  Brazil
Canada, Quebec
      McGill University, Montreal,  Quebec,  Canada
France
      CHU Pitie-Salpetriere, Paris,  75651,  France
Germany
      Charite- University Medicine, Berlin,  Germany
      Klinikum Augsburg, Augsburg,  Germany
      University Hospial of Mannheim, Mannheim,  Germany
      University Hospital Wuerzburg, Wuerzburg,  Germany
      University of Jena, Jena,  07740,  Germany
      University of Tuebingen, Tuebingen,  Germany
      University of Ulm, Ulm,  Germany
Ireland
      Cork University, Cork,  Ireland
Israel
      Tel-Aviv Medical Center, Tel Aviv,  62995,  Israel
Italy
      Istituto Nazionale dei Tumori, Naples,  80132,  Italy
      Istituto Nazionale Tumori di Milano, Milan,  20133,  Italy
      Instituto Eurepeo di Oncologia, Milan,  20141,  Italy
Netherlands
      University Hospital of Groningen, Groningen,  Netherlands
New Zealand
      North Shore Hospital, Auckland,  92024,  New Zealand
Switzerland
      University of Zurich, Zurich,  Switzerland
United Kingdom, England
      Harley Street Clinic, London,  England,  SW17 ORE,  United Kingdom

Study ID Numbers:  CV-MMAIT-4-001; JWCI-MC-4-001
Record last reviewed:  April 2005
Last Updated:  April 6, 2005
Record first received:  January 23, 2003
ClinicalTrials.gov Identifier:  NCT00052156
Health Authority: United States: Food and Drug Administration
ClinicalTrials.gov processed this record on 2005-04-08