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Yersinia pestis Infection |
Yersinia pestis |
Clinical Trial: Analysis of Genetic Factors Which May Influence the Course of HIV Infection
This study is currently recruiting patients.
Verified by Hadassah Medical Organization September 2005
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Purpose
Patients with HIV an have a variable course of their infection. We are trying to identify factors which worsen or ameliorate the course of the disease. Such factors may be related to metabolism (breakdown) of drugs or to iron handling by the body.
| Condition |
|---|
| HIV Infection |
MedlinePlus related topics: AIDS
Study Type: Observational
Study Design: Natural History, Longitudinal, Convenience Sample, Retrospective/Prospective Study
Official Title: Genetic Influences on the Course and Response to Treatment of HIV: Contribution of Polymorphisms in Drug Metabolism and Disposition Genes and Haptoglobin Polymorphisms
Further Study Details:
Study start: February 2004
Patients with HIV can have a variable course and the disease may be influenced by polymorphisms in drug metabolism and disposition genes such as MDR1 and CYP3A4. In addition, reports have linked changes in the course of the disease with iron status, with high iron being detrimental. We will study polymorphisms in these genes and correlate with clinical course in HIV patients and also with phenotype of drug resistance and disease parameters (such as CD4 counts and opportunistic infections).
Eligibility
Ages Eligible for Study: 18 Years and above, Genders Eligible for Study: Both
Criteria
Inclusion Criteria:
- diagnosis of HIV
Exclusion Criteria:
- under 18 years of age
Location and Contact Information
Please refer to this study by ClinicalTrials.gov identifier NCT00159068
Arik Tzukert, DMD 00 972 2 6776095 arik@hadassah.org.il
Hadas Lemberg, PhD 00 972 2 6777572 lhadas@hadassah.org.il
Hadas Lemberg, PhD 00 972 2 6777572 lhadas@hadassah.org.il
Israel
Hadassah Medical Organization, Jerusalem, IL91120, Israel; Recruiting
Arik Tzukert, DMD 00 972 2 6776095 arik@hadassah.org.il
Hadas l, PhD 00 972 2 6777572 lhadas@hadassah.org.il
Deborah Rund, MD, Principal Investigator
Hadas l, PhD 00 972 2 6777572 lhadas@hadassah.org.il
Deborah Rund, MD, Principal Investigator
Study chairs or principal investigators
Deborah Rund, MD, Principal Investigator, Hadassah Medical Organization
More Information
Publications
Tang J, Kaslow RA. The impact of host genetics on HIV infection and disease progression in the era of highly active antiretroviral therapy. AIDS. 2003;17 Suppl 4:S51-60. Review. No abstract available.
Study ID Numbers: 391-20.02.04
Last Updated: September 11, 2005
Record first received: September 9, 2005
ClinicalTrials.gov Identifier: NCT00159068
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration
ClinicalTrials.gov processed this record on 2005-09-13
Last Updated: September 11, 2005
Record first received: September 9, 2005
ClinicalTrials.gov Identifier: NCT00159068
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration
ClinicalTrials.gov processed this record on 2005-09-13
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