The purpose of this study is to test the efficacy of a computerized telephone system called TLC (Telephone-Linked Care) in helping subjects adhere to their anti-depressant medication regimens.

Condition	Intervention
Depression	Behavior: Computer Assisted Education for Behavior Change

Further Study Details: 

Primary Outcomes: Antidepressant Medication Adherence, measured monthly for four months; Adherence to Scheduled Psychiatry Clinic Visits, measured monthly for four months
Secondary Outcomes: Depression Status, measured by self-administered depression inventory scale at baseline and at four months follow-up; General Health Status, measured by self rating health survey at baseline and at four months follow-up
Expected Total Enrollment:  144

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

• A clinical diagnosis of Major Depressive Disorder (296.2 or 296.3), and/or Dysthymic Disorder (300.4), and/or, Depressive Disorder NOS (311).
• Prescribed at least one antidepressant medication.
• > 18 years of age.
• Speak and understand conversational English.

Exclusion Criteria:

• Current significant alcohol or drug abuse.
• Bipolar disorder (296.4 or higher), Schizo-affective disorder (295.70), or significantly personality disorder (301.x).
• Parkinson''''s Disease, Huntington''''s Disease, ALS, or other neuro-degenerative diseases.
• Alzheimer''''s Disease and other dementia.
• Cancer, undergoing radiation therapy or chemotherapy.
• Renal disease. On dialysis.
• Immunologic disorder (Rheumatoid arthritis, SLE, etc.).
• HIV.
• Terminal Illness.
• Homeless.
• Legally blind.
• No access to a telephone with touch-tone service.
• Planning to leave the geographic area during the study period.

Massachusetts
      Boston Medical Center, Boston,  Massachusetts,  02118,  United States

Study chairs or principal investigators

Ramesh Farzanfar,  Study Director,  Boston University Medical Center   

Study ID Numbers:  MH63937
Last Updated:  August 26, 2005
Record first received:  August 25, 2005
ClinicalTrials.gov Identifier:  NCT00136240
Health Authority: United States: Institutional Review Board
ClinicalTrials.gov processed this record on 2005-09-13