Food Contamination and Poisoning

Yersinia

Clinical Trial: Lead Mobilization & Bone Turnover in Pregnancy/Lactation

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Purpose
Eligibility
More Information

This study is no longer recruiting patients.

Sponsored by:	National Institute of Environmental Health Sciences (NIEHS)
Information provided by:	National Institute of Environmental Health Sciences (NIEHS)

Purpose

We are examining the role of maternal bone lead turnover during pregnancy and lactation as a potential source of lead exposure for the fetus and the infant (via breast milk). A cohort, ascertained at entry to care, consists of >1000 women to be followed through pregnancy. In the postpartum subjects are recruited for a nested case control study to assess the influence of lactation on maternal bone density, maternal blood lead and breast milk lead.

Condition
Lead Poisoning

MedlinePlus related topics: Lead Poisoning

Study Type: Observational
Study Design: Natural History, Longitudinal, Convenience Sample, Prospective Study

Further Study Details:

Expected Total Enrollment: 1000

Study start: August 1996; Study completion: December 2002

Eligibility

Ages Eligible for Study: 12 Years - 35 Years, Genders Eligible for Study: Female

Accepts Healthy Volunteers

Criteria

1.Positive pregnancy test, age 12-35 and informed consent; 2.Gestation <28 weeks at entry to prenatal care; 3.No history of serious chronic or metabolic diseases, which could affect maternal growth or bone density; 4.Not corticosteroid user or diagnosed use of illicit drugs; 5.Eligible for lactation study: Ascertainment during or participation in the pregnancy study and a negative pregnancy test.

More Information

Publications

Sowers M, Jannausch M, Scholl T, Schall J. The reproducibility of ultrasound bone measures in a triethnic population of pregnant adolescents and adult women. J Bone Miner Res. 1998 Nov;13(11):1768-74.

Sowers MF, Scholl T, Harris L, Jannausch M. Bone loss in adolescent and adult pregnant women. Obstet Gynecol. 2000 Aug;96(2):189-93.

Scholl TO. High third-trimester ferritin concentration: associations with very preterm delivery, infection, and maternal nutritional status. Obstet Gynecol. 1998 Aug;92(2):161-6.

Goodlin RC. High third-trimester ferritin concentration: associations with very preterm delivery, infection, and maternal nutritional status. Obstet Gynecol. 1999 Jan;93(1):156. No abstract available.

Scholl TO. Teenage pregnancy. In "Cambridge Encyclopedia of Growth and Development", SJ Ulijaszek, FE Johnson, MA Preece (eds), Cambridge Univ Press, 312-13,1998

Scholl TO, Reilly T. Essential trace elements and mineral nutrition in human pregnancy. In "Clinical nutrition of the essential trace elements and mineral - The Guide for Health Professionals", John R. Bogden, Leslie Klevay (eds), Humana Press, 1999. ( In press)

Study ID Numbers: 7437-CP-001
Record last reviewed: July 2002
Last Updated: October 13, 2004
Record first received: February 27, 2001
ClinicalTrials.gov Identifier: NCT00011726
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08

Source: ClinicalTrials.gov
Cache Date: April 9, 2005

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Lead Mobilization & Bone Turnover in Pregnancy/Lactation - Article

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Food Contamination and Poisoning

Yersinia

Clinical Trial: Lead Mobilization & Bone Turnover in Pregnancy/Lactation

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Purpose

Eligibility

More Information

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Lead Mobilization & Bone Turnover in Pregnancy/Lactation - Article

General Topics A-Z

Food Contamination and Poisoning

Yersinia

Clinical Trial: Lead Mobilization & Bone Turnover in Pregnancy/Lactation

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Purpose

Eligibility

More Information

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