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CPR |
Cardiopulmonary Resuscitation |
Clinical Trial: Effects of Epinephrine and Intravenous (I.V.) Needle On Cardiopulmonary Resuscitation (CPR) Outcome
This study is currently recruiting patients.
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Purpose
Intravenous epinephrine has been part of the guidelines for cardiopulmonary resuscitation since the start. It improves outcome in animal studies, but has never been investigated in a controlled study in humans. Epidemiologic data indicate that it is an independent negative predictor for survival. If this is true in a controlled randomized study, it could be due to effects of the drug itself or more likely due to reduced quality of chest compressions and ventilations due to the time spent on placing an I.V. needle and injecting drugs.
| Condition | Intervention | Phase |
|---|---|---|
| Cardiac Arrest | Drug: epinephrine and intravenous needle | Phase II |
MedlinePlus related topics: Heart Diseases
Study Type: Interventional
Study Design: Treatment, Randomized, Open Label, Placebo Control, Parallel Assignment, Safety/Efficacy Study
Official Title: Effects of Epinephrine and I.V. Needle On CPR Outcome
Further Study Details:
Primary Outcomes: survival to hospital discharge with neurologic outcome
Secondary Outcomes: admit to hospital with spontaneous circulation; one year survival with neurologic outcome
Expected Total Enrollment: 900
Secondary Outcomes: admit to hospital with spontaneous circulation; one year survival with neurologic outcome
Expected Total Enrollment: 900
Study start: January 2003
Last follow-up: May 2005
In a randomized, controlled study of all out-of-hospital cardiac arrest patients in Oslo, Norway, half the patients are treated according to the international guidelines for advanced CPR, and the other half according to the same guidelines, except for no I.V. needle or drugs are given until 5 minutes after eventual return of spontaneous circulation.
Eligibility
Ages Eligible for Study: 18 Years and above, Genders Eligible for Study: Both
Criteria
Inclusion Criteria:
- Cardiac arrest out-of-hospital
Exclusion Criteria:
- <18 years old
- Trauma as cause of arrest
Location and Contact Information
Please refer to this study by ClinicalTrials.gov identifier NCT00121524
Lars Wik, MD, PhD +47 91728966 lars.wik@medisin.uio.no
Petter A Steen, prof., MD, PhD +47 90686007 p.a.steen@medisin.uio.no
Petter A Steen, prof., MD, PhD +47 90686007 p.a.steen@medisin.uio.no
Norway
Ulleval University Hospital, Oslo, N-0407, Norway; Recruiting
Lars Wik, MD, PhD +47 91728966 lars.wik@medisin.uio.no
Petter A Steen, prof., MD, PhD +47 90686007 p.a.steen@medisi.uio.no
Lars Wik, MD, PhD, Principal Investigator
Petter A Steen, prof., MD, PhD, Sub-Investigator
Petter A Steen, prof., MD, PhD +47 90686007 p.a.steen@medisi.uio.no
Lars Wik, MD, PhD, Principal Investigator
Petter A Steen, prof., MD, PhD, Sub-Investigator
Study chairs or principal investigators
Lars Wik, MD, PhD, Principal Investigator, Ullevaal University Hospital
More Information
Publications
Holmberg M, Holmberg S, Herlitz J. Low chance of survival among patients requiring adrenaline (epinephrine) or intubation after out-of-hospital cardiac arrest in Sweden. Resuscitation. 2002 Jul;54(1):37-45.
Study ID Numbers: 525-02201
Record last reviewed: July 2005
Last Updated: July 25, 2005
Record first received: July 20, 2005
ClinicalTrials.gov Identifier: NCT00121524
Health Authority: Norway: The National Committees for Research Ethics in Norway
ClinicalTrials.gov processed this record on 2005-07-26
Record last reviewed: July 2005
Last Updated: July 25, 2005
Record first received: July 20, 2005
ClinicalTrials.gov Identifier: NCT00121524
Health Authority: Norway: The National Committees for Research Ethics in Norway
ClinicalTrials.gov processed this record on 2005-07-26
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