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Depression |
Depression/depressive Disorders |
Clinical Trial: Comparison of Three Electroconvulsive Therapy (ECT) Techniques for the Treatment of Major Depression
This study is currently recruiting patients.
|
Purpose
The purpose of this study is to compare the antidepressant benefits and cognitive side effects of three different types of electroconvulsive therapy (ECT) in individuals with unipolar or bipolar depression.
| Condition | Treatment or Intervention |
|---|---|
| Depression | Procedure: Electroconvulsive Therapy |
MedlinePlus related topics: Depression
Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Active Control, Parallel Assignment, Safety/Efficacy Study
Official Title: Comparing Three Electrode Placements to Optimize ECT
Expected Total Enrollment: 360
Study start: February 2003; Expected completion: May 2006
ECT is an important treatment for severely depressed people who do not respond adequately to, or are intolerant of, antidepressant medication. Traditionally, ECT has been administered with one of two standard techniques: bilateral and right unilateral electrode placement. However, these techniques are limited by either low efficacy or high cognitive impairment. Recently, an additional technique for ECT administration has shown promise in preliminary studies: bifrontal ECT. This study will compare this technique to the two traditional ECT techniques in treating people with depressive symptoms.
Participants in this study will be randomly assigned to receive standard bilateral ECT, high-dose right unilateral ECT, or bifrontal ECT in their index course. Depression symptoms, neuropsychological status, and quality of life will be measured throughout the course of the ECT treatment, one week after, and at a 2-month follow-up visit. This study will run for 4 years.
Eligibility
Ages Eligible for Study: 18 Years and above, Genders Eligible for Study: Both
Criteria
Inclusion Criteria:
- Diagnosis of unipolar or bipolar depression
Location and Contact Information
Minnesota
Mayo Clinic, Rochester, Minnesota, United States; Recruiting
Keith Rasmussen, MD, Principal Investigator
New Jersey
UMDNJ, Newark, New Jersey, 07103, United States; Recruiting
Charles Kellner, MD, Principal Investigator
New York
Northshore/Long Island Jewish Hillside Hospital, Glen Oaks, New York, 11004, United States; Recruiting
Georgios Petrides, MD, Principal Investigator
Texas
University of Texas Southwestern Medical Center, Dallas, Texas, 75235, United States; Recruiting
Mustafa Husain, MD, Principal Investigator
More Information
Record last reviewed: November 2004
Last Updated: November 29, 2004
Record first received: September 24, 2003
ClinicalTrials.gov Identifier: NCT00069407
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 9, 2005
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