The purpose of this study is to examine the effects of continuing antidepressant medication in nursing home residents who no longer have depressive symptoms. The usefulness of continuing maintenance treatment for depression will be determined.

There are approximately 1.6 million nursing home residents in the United States. More than one third of these residents are taking antidepressant medications (ADs). Although ADs are effective, evidence suggests that they can lead to significant adverse events, including an increased risk of bone fractures and impairments of the nervous system which increase the risk of dangerous falls. Many depressed nursing home residents suffer from an initial episode of late life depression and do not meet guideline-based recommendations for maintenance treatment. This study will examine the benefits and risks of long-term AD treatment in depressed nursing home residents whose depression has been in remission.

Participants will be randomly assigned to either continue or discontinue AD treatment. Participants will be monitored for recurrence of depression and related symptoms for 1 year. Self reports and depression scales will be used to assess participants.

Ages Eligible for Study:  65 Years and above,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

• Current use of antidepressant medication
• Have been in remission from first episode of depression for 6 months or longer
• Of sound mind

Exclusion Criteria:

• Bedridden
• Severe cognitive impairment