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Neurotoxicity Information Page - Article


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Neurological Diseases And Disorders

Nerve Diseases; Neurologic Diseases

Article: Neurotoxicity Information Page

What is Neurotoxicity?


Neurotoxicity occurs when the exposure to natural or manmade toxic substances (neurotoxicants) alters the normal activity of the nervous system. This can eventually disrupt or even kill neurons, key cells that transmit and process signals in the brain and other parts of the nervous system. Neurotoxicity can result from exposure to substances used in chemotherapy, radiation treatment, drug therapies, and organ transplants, as well as exposure to heavy metals such as lead and mercury, certain foods and food additives, pesticides, industrial and/or cleaning solvents, cosmetics, and some naturally occurring substances. Symptoms may appear immediately after exposure or be delayed. They may include limb weakness or numbness; loss of memory, vision, and/or intellect; headache; cognitive and behavioral problems; and sexual dysfunction. Individuals with certain disorders may be especially vulnerable to neurotoxicants.

Is there any treatment?

Treatment involves eliminating or reducing exposure to the toxic substance, followed by symptomatic and supportive therapy.

What is the prognosis?

The prognosis depends upon the length and degree of exposure and the severity of neurological injury. In some instances, exposure to neurotoxicants can be fatal. In others, patients may survive but not fully recover. In other situations, many individuals recover completely after treatment.

What research is being done?

The NINDS supports research on disorders of the brain and nervous system such as neurotoxicity, aimed at learning more about these disorders and finding ways to prevent and treat them. Scientists are investigating the role occupational or environmental toxicants have on progressive neurodegenerative disorders such as Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, and dementia. Also being studied are the mechanisms that trigger neuroimmune responses in the central nervous system and the possibility that some brain disorders in children may occur when environmental triggers interact with genes.

Select this link to view a list of studies currently seeking patients.

Organizations

National Institute of Environmental Health Sciences (NIEHS)
National Institutes of Health, DHHS
31 Center Drive, Rm. B1C02 MSC 2256
Bethesda, MD   20892-2256
webcenter@niehs.nih.gov
http://www.niehs.nih.gov
Tel: 301-496-3511 Information: 919-541-3345

 Food and Drug Administration (FDA)
U.S. Department of Health and Human Services
5600 Fishers Lane, CDER-HFD-240
Rockville, MD   20857
http://www.fda.gov
Tel: 301-827-4573 888-INFO-FDA (463-6332)


Source: National Institute of Neurological Disorders and Stroke
Cache Date: December 15, 2004


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October 11, 2008


Page Updated: October 1, 2005
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