Not Signed In -
Sciatica |
Ciatica; Siatica |
Clinical Trial: Effect of Antidepressants on Back Pain
This study has been completed.
|
Purpose
The purpose of this study is to determine whether different types of antidepressant medicines relieve back pain that has lasted at least six months on a daily basis. Study participants will be assigned to treatment with either a antidepressant acting on the serotonin system in the brain (fluoxetine), one acting on the noradrenoline system (desipramine, or to a control medication not expected to relieve pain (benztropine). Each participant will be seen at least nine times during their 12 weeks on medication. This is a phase 2/3, outpatient study.
| Condition | Treatment or Intervention | Phase |
|---|---|---|
| Back Pain Sciatica | Drug: Fluoxetine Drug: Desipramine Drug: Benztropine | Phase II |
MedlinePlus related topics: Back Pain; Sciatica
Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Official Title: Efficacy of Antidepressants in Chronic Back Pain
Study start: April 1999; Study completion: March 2002
Eligibility
Ages Eligible for Study: 18 Years - 65 Years, Genders Eligible for Study: Both
Criteria
- Chronic back pain (pain on a daily basis for six months or longer)
- Age 18-65
- No major medical illness
Location Information
California
Department of Veterans Affairs, San Diego, California, 92161, United States
Mark A Slater, Ph.D
Edmund V Capparelli, Pharm.D.
Mark Wallace, M.D.
Steve R Garfin, M.D.
More Information
Record last reviewed: December 2004
Last Updated: December 30, 2004
Record first received: July 3, 2001
ClinicalTrials.gov Identifier: NCT00018200
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 9, 2005
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