Retinoblastoma

Glioblastoma, retinal; Glioma, retinal; Neuroblastoma, retinal; RB

Retinoblastoma is a cancer of the retina. Development of this tumor is initiated by mutations that inactivate both copies of the RB1-gene, which codes for the Rb-1 protein. It occurs mostly in children before the age 5 years and accounts for about 3% of the cancers occurring in children younger than 15 years. The estimated annual incidence is approximately 4 per million children [1]. The tumor may begin in one or both eyes. Retinoblastoma is usually confined to the eye but can spread to th ...