RATIONALE: Radioactive drugs such as holmium Ho 166 DOTMP can kill cancer cells without harming healthy cells. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by radiation therapy.

PURPOSE: Phase I/II trial to study the effectiveness of holmium Ho 166 DOTMP followed by peripheral stem cell transplantation in treating patients who have metastatic Ewing's sarcoma or rhabdomyosarcoma that has spread to the bone.

Condition	Treatment or Intervention	Phase
recurrent childhood rhabdomyosarcoma recurrent adult soft tissue sarcoma adult rhabdomyosarcoma stage IVB adult soft tissue sarcoma stage IVA adult soft tissue sarcoma bone metastases previously treated childhood rhabdomyosarcoma metastatic tumors of the Ewing's family recurrent tumors of the Ewing's family	Drug: holmium Ho 166 DOTMP  Procedure: biological response modifier therapy  Procedure: bone marrow ablation with stem cell support  Procedure: isotope therapy  Procedure: peripheral blood stem cell transplantation  Procedure: radiation therapy	Phase I Phase II

Further Study Details: 

OBJECTIVES:

• Determine the dosimetry of holmium Ho 166 DOTMP in patients with metastatic Ewing's sarcoma family of tumors or rhabdomyosarcoma with bone metastases.
• Provide treatment with holmium Ho 166 DOTMP for these patients.
• Determine the toxicity and pharmacokinetics of this drug in these patients.
• Determine the change in tumor cell content in peripheral blood and bone marrow after treatment with this drug in these patients.

OUTLINE: Patients receive a trace dose of holmium Ho 166 DOTMP IV over 10 minutes on day -7 and an assigned dose over 10 minutes on day 0. Autologous peripheral blood stem cells are infused on days 7-10.

Patients are followed at least weekly for 4 weeks and then monthly for 1 year or until disease progression.

PROJECTED ACCRUAL: A total of 4 patients will be accrued for this study.

Ages Eligible for Study:  12 Years and above,  Genders Eligible for Study:  Both

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed Ewing's sarcoma family of tumors or rhabdomyosarcoma with bone metastases
• Refractory to conventional therapy OR
• Responsive to conventional therapy with osseous metastases at diagnosis that are extensive enough to preclude concurrent radiotherapy to all sites
• Soft tissue, pulmonary, and/or bone marrow metastases in addition to cortical bone allowed
• Extraosseous sites of disease allowed if amenable to surgical resection or external beam radiotherapy
• No patients under 10 years old with embryonal rhabdomyosarcoma
• Adequate peripheral blood stem cells stored
• At least 2,500,000 CD34+ cells/kg
• No impending bone fracture or spinal cord compression

PATIENT CHARACTERISTICS: Age:

• 12 and over

Performance status:

• 0-2

Life expectancy:

• At least 2 months

Hematopoietic:

• Absolute neutrophil count at least 1,000/mm^3
• Platelet count at least 75,000/mm^3 (transfusion independent)
• Hemoglobin at least 10.0 g/dL (RBC transfusion allowed)

Hepatic:

• Bilirubin no greater than 1.5 times normal
• SGOT no greater than 2.5 times normal

Renal:

• Radioisotope glomerular filtration rate, iothalamate clearance, or creatinine clearance at least 60 mL/min

Other:

• No uncontrolled infection
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY: Biologic therapy:

• Recovered from prior immunotherapy
• At least 3 months since prior bone marrow or peripheral blood stem cell transplantation (6 months for total body irradiation conditioning) and recovered
• At least 1 week since prior cytokines
• No immunomodulators during and for at least 4 weeks after study
• No concurrent cytokines

Chemotherapy:

• At least 3 weeks since prior chemotherapy (6 weeks for nitrosoureas) and recovered
• No more than 3 prior systemic chemotherapy regimens
• No systemic chemotherapy during and for at least 4 weeks after study

Endocrine therapy:

• Not specified

Radiotherapy:

• See Disease Characteristics
• See Biologic therapy
• Recovered from prior radiotherapy
• No prior maximum tolerable radiotherapy (greater than 30 Gy) to the spinal cord
• No prior therapeutic doses of bone-seeking radiopharmaceutical (e.g., samarium Sa 153 lexidronam pentasodium EDTMP)
• No radiotherapy during and for at least 4 weeks after study
• Local radiotherapy to any tumor site allowed provided at least 1 evaluable lesion is untreated

Surgery:

• See Disease Characteristics
• No surgical resection of all bone metastases evaluable by PET during and for 1 month after study

Other:

• At least 4 weeks since prior bisphosphonates

Washington
      Fred Hutchinson Cancer Research Center, Seattle,  Washington,  98109-1024,  United States

Study chairs or principal investigators

Douglas Hawkins, MD,  Study Chair,  Fred Hutchinson Cancer Research Center   

Study ID Numbers:  CDR0000068159; FHCRC-1474.00; CHMC-S-6007; NCI-G00-1842
Record last reviewed:  April 2003
Last Updated:  October 13, 2004
Record first received:  September 11, 2000
ClinicalTrials.gov Identifier:  NCT00006234
Health Authority: Unspecified
ClinicalTrials.gov processed this record on 2005-04-08