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Dementia - Multi-Infarct |
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Clinical Trial: Brain Study of Patients with Frontal Lobe Dementia and Parkinsonian Disorders
This study is currently recruiting patients.
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Purpose
The Cognitive Neuroscience Section of the National Institute of Neurological Disorders and Stroke proposes to continue its cross-sectional and longitudinal studies of cerebral metabolism in frontal lobe dementias and atypical basal ganglia disorders. These studies include repeated assessments of neuropsychological and brain anatomical and metabolic function in subjects with these important and possibly related brain disorders.
| Condition | Treatment or Intervention |
|---|---|
| Alzheimer's Disease Dementia Down's Syndrome | Drug: 18 FDG |
MedlinePlus related topics: Alzheimer's Caregivers; Alzheimer's Disease; Dementia; Down Syndrome
Genetics Home Reference related topics: Alzheimer disease; Down syndrome
Study Type: Observational
Study Design: Natural History
Official Title: Regional Cerebral Utilization of Glucose in Patients with a Diagnosis of Frontal Lobe Dementia, Atypical Parkinsonian Disorder, and Other Basal Ganglia Disorders
Expected Total Enrollment: 483
Study start: January 19, 1981
The Cognitive Neuroscience Section of the National Institute of Neurological Disorders and Stroke proposes to continue its cross-sectional and longitudinal studies of cerebral metabolism in frontal lobe dementias and atypical basal ganglia disorders. These studies include repeated assessments of neuropsychological and brain anatomical and metabolic function in subjects with these important and possibly related brain disorders.
Eligibility
Genders Eligible for Study: Both
Accepts Healthy Volunteers
Criteria
Patients with frontotemporal dementia and atypical basal ganglia disorders will be recruited from neurological and psychiatric clinics, from self or family referral in response to advertisements or from private physicians.
Only patients without evidence or history of significant chronic disease who meet standard clinical criteria for the diagnosis of dementia of the Frontotemporal disease type (possible or probable) or atypical basal ganglia disease (e.g., CBD) will be accepted into this protocol.
Normal volunteers will be recruited through the NIH normal volunteer office and will undergo the same screening process as the patient group.
All subjects need to be off all medications, except for thyroid replacement, for the two weeks prior to the PET scan, and off psychotropic medication for one month.
EXCLUSION CRITERIA:
No subject will be accepted for study if he or she shows undue anxiety or appears unmanageable.
Subjects will be cautioned not to consume alcohol, marijuana, or psychotropic drugs while on the study, nor to smoke for at least 24 hours prior to the PET scan.
Urine pregnancy tests will be conducted prior to PET and MRI scans in women of childbearing age.
Location and Contact Information
Maryland
National Institute of Neurological Disorders and Stroke (NINDS), 9000 Rockville Pike, Bethesda, Maryland, 20892, United States; Recruiting
TTY 1-866-411-1010
More Information
Detailed Web Page
Publications
Schwartz M, Creasey H, Grady CL, DeLeo JM, Frederickson HA, Cutler NR, Rapoport SI. Computed tomographic analysis of brain morphometrics in 30 healthy men, aged 21 to 81 years. Ann Neurol. 1985 Feb;17(2):146-57.
Schlageter NL, Horwitz B, Creasey H, Carson R, Duara R, Berg GW, Rapoport SI. Relation of measured brain glucose utilisation and cerebral atrophy in man. J Neurol Neurosurg Psychiatry. 1987 Jun;50(6):779-85.
Duara R, Grady C, Haxby J, Ingvar D, Sokoloff L, Margolin RA, Manning RG, Cutler NR, Rapoport SI. Human brain glucose utilization and cognitive function in relation to age. Ann Neurol. 1984 Dec;16(6):703-13.
Record last reviewed: January 3, 2005
Last Updated: January 26, 2005
Record first received: November 3, 1999
ClinicalTrials.gov Identifier: NCT00001178
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 8, 2005
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