Eosinophils are a type of white blood cell. Elevated eosinophil levels can damage the heart, nerves, and other organs, in the syndrome known as hypereosinophilic syndrome (HES). Some individuals have a hereditary form of HES known as familial eosinophilia (FE). More research on the causation and mechanisms of HES is needed in order to design more effective and less toxic therapies.

This study will investigate FE and its genetic causes, damage mechanisms, and disease markers (such as blood test abnormalities). It will enroll approximately 20 individuals (both adults and children) from a previously studied family with FE. This is a long-term study of indefinite duration.

Participants will undergo yearly clinical examinations including medical history, physical examination, bloodwork, EKG, echocardiogram, and pulmonary function tests, with additional or more frequent examinations and tests as required. In addition, participants will donate blood and tissue for research purposes. Both adult and child participants will donate blood. At the initial evaluation, adult participants will donate bone marrow. During the study, some adult participants will also undergo a limited number of leukaopheresis sessions, in which blood is donated from one arm, the blood is separated into red blood cells and other components, and the red blood cells are returned into the donor's other arm.

Condition
Eosinophilia

Further Study Details: 

Expected Total Enrollment:  20

Affected members of a previously studied familial hypereosinophilia (FE) will be admitted on this protocol. A thorough clinical evaluation will be performed yearly with emphasis on potential sequelae of eosinophil-mediated tissue damage. Blood cells and/or serum will also be collected to provide reagents (such as DNA, RNA, and specific antibodies) for use in the laboratory to address issues related to the genetic and immunologic basis of FE as well as its pathogenesis. It is anticipated that patients will undergo a more extensive evaluation than is generally available and that the specimens collected from them will prove to be valuable reagents for laboratory studies related to eosinophilia, eosinophil activation and function. While the study is not designed to address the question of therapy for FE, in patients for whom medical therapy is indicated (for either the hypereosinophilia itself or its sequelae), appropriate treatment will be instituted by our clinical service or the patients' local physicians. No experimental chemotherapy is involved in this protocol.

Genders Eligible for Study:  Both

Criteria

INCLUSION CRITERIA:
-genetically related member of the previously identified family with FE
-documented eosinophilia greater than 1,500/mm(3) on at least two occasions
EXCLUSION CRITERIA:
-an alternative explanation for eosinophilia greater than 1,500/mm(3) (ex. Hypersensitivity reaction, parasitic infection)

Maryland
      National Institute of Allergy and Infectious Diseases (NIAID), 9000 Rockville Pike,  Bethesda,  Maryland,  20892,  United States; Recruiting

Study ID Numbers:  040286; 04-I-0286
Record last reviewed:  September 3, 2004
Last Updated:  February 17, 2005
Record first received:  September 17, 2004
ClinicalTrials.gov Identifier:  NCT00091871
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08