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Clinical Trial: Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers
This study is currently recruiting patients.
Verified by University Hospital Angers September 2005
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Purpose
| Condition | Intervention | Phase |
|---|---|---|
| Healthy volunteers | Device: pressure strain system, iontophoresis Drug: scopolamin Drug: emla Drug: capsaicin Drug: aspirin Drug: clopidogrel Drug: celecoxib Drug: indomethacin Drug: acetylcholine Drug: sodium nitroprusside Drug: brethyllium Device: general and local heating | Phase IV |
MedlinePlus consumer health information
Study Type: Interventional
Study Design: Diagnostic, Randomized, Double-Blind, Placebo Control, Parallel Assignment
Official Title: Etude De La Reserve Vasomotrice Microcirculatoire cutanée
Secondary Outcomes: Kinetics of the vasomotor response to stimuli
Expected Total Enrollment: 85
Study start: January 1996; Expected completion: January 2007
Last follow-up: January 2007; Data entry closure: January 2007
Eligibility
Accepts Healthy Volunteers
Inclusion Criteria:
- Healthy volunteers with no clinical signs of, or risk factors for, vascular disease
Exclusion Criteria:
- Smokers, Pregnancy, Allergy,
Location and Contact Information
France
Laboratoire de Physiologie et Explorations Vasculaires - CHU Angers, Angers, 49033, France; Recruiting
Jean Louis SAUMET, MD - PhD, Principal Investigator, University Hospital Angers
More Information
Publications that report results of this study
Tartas M, Durand S, Koitka A, Bouye P, Saumet JL, Abraham P. Anodal current intensities above 40 microA interfere with current-induced axon-reflex vasodilatation in human skin. J Vasc Res. 2004 May-Jun;41(3):261-7. Epub 2004 May 19.
Durand S, Fromy B, Humeau A, Sigaudo-Roussel D, Saumet JL, Abraham P. Break excitation alone does not explain the delay and amplitude of anodal current-induced vasodilatation in human skin. J Physiol. 2002 Jul 15;542(Pt 2):549-57.
Tartas M, Bouye P, Koitka A, Durand S, Gallois Y, Saumet JL, Abraham P. Early vasodilator response to anodal current application in human is not impaired by cyclooxygenase-2 blockade. Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1668-73. Epub 2004 Nov 24.
Durand S, Tartas M, Bouye P, Koitka A, Saumet JL, Abraham P. Prostaglandins participate in the late phase of the vascular response to acetylcholine iontophoresis in humans. J Physiol. 2004 Dec 15;561(Pt 3):811-9. Epub 2004 Oct 21.
Durand S, Fromy B, Tartas M, Jardel A, Saumet JL, Abraham P. Prolonged aspirin inhibition of anodal vasodilation is not due to the trafficking delay of neural mediators. Am J Physiol Regul Integr Comp Physiol. 2003 Jul;285(1):R155-61.
Durand S, Fromy B, Koitka A, Tartas M, Saumet JL, Abraham P. Oral single high-dose aspirin results in a long-lived inhibition of anodal current-induced vasodilatation. Br J Pharmacol. 2002 Oct;137(3):384-90.
Durand S, Fromy B, Bouye P, Saumet JL, Abraham P. Vasodilatation in response to repeated anodal current application in the human skin relies on aspirin-sensitive mechanisms. J Physiol. 2002 Apr 1;540(Pt 1):261-9.
Last Updated: September 8, 2005
Record first received: September 8, 2005
ClinicalTrials.gov Identifier: NCT00152724
Health Authority: France: Ministry of Health
ClinicalTrials.gov processed this record on 2005-09-13
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