RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Epoetin alfa may stimulate red blood cell production and treat anemia in patients with head and neck cancer. It is not yet known whether receiving radiation therapy with epoetin alfa is more effective than radiation therapy alone for anemic patients with head and neck cancer.

PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy with or without epoetin alfa in treating anemic patients who have head and neck cancer.

Condition	Treatment or Intervention	Phase
Anemia Hypopharyngeal Cancer Laryngeal Cancer lip and oral cavity cancer Oropharyngeal Cancer	Drug: cisplatin  Drug: epoetin alfa  Procedure: biological response modifier therapy  Procedure: chemoprotection  Procedure: chemotherapy  Procedure: colony-stimulating factor therapy  Procedure: cytokine therapy  Procedure: hematologic toxicity attenuation  Procedure: radiation therapy  Procedure: radioprotection  Procedure: supportive care/therapy	Phase III

Further Study Details: 

OBJECTIVES:

• Determine whether epoetin alfa given during definitive radiotherapy or chemoradiotherapy improves the local-regional control rate in anemic patients with squamous cell carcinoma of the head and neck.
• Determine whether this drug improves survival in this patient population.
• Identify patterns in first failure in these patients.
• Determine whether there is a significant increase in hemoglobin level between the baseline value and the value at 28 days after starting epoetin alfa in these patients.
• Assess the toxicity of this regimen in these patients.
• Assess the quality of life of patients treated with this regimen.

OUTLINE: This is a randomized study. Patients are stratified according to stage (I/II vs III/IV without chemotherapy vs III/IV with chemotherapy), pretreatment hemoglobin level (9.0 to less than 11.5 g/dL vs 11.5 to 13.5 g/dL), and gender. Patients are randomized to one of two treatment arms.

• Arm I: Patients with stage I or II disease undergo radiotherapy once daily for 6-7 weeks. Patients with stage III or IV disease undergo radiotherapy once daily for 3.5 weeks and then twice daily (6 hours apart) for 2.5 weeks for a total of 6 weeks.
• Arm II: Patients undergo radiotherapy as in arm I. Beginning 7-10 days before radiotherapy, patients receive epoetin alfa subcutaneously once weekly until the end of radiotherapy. Patients with stage III/IV disease may receive concurrent cisplatin IV over 1-2 hours on days 1 and 22 of radiotherapy.

Quality of life is assessed at baseline, at the end of radiotherapy, 4 weeks after treatment, and then every 6 months for 2 years.

Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.

PROJECTED ACCRUAL: A total of 372 patients (186 per arm) will be accrued for this study within 3.5 years.

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed invasive squamous cell carcinoma of the head and neck, including carcinoma arising from the oral cavity, oropharynx, larynx, and hypopharynx
• Stage I-IV disease
• No distant metastases
• No carcinoma of the nasopharynx, nasal cavity/paranasal sinuses, or salivary glands
• No carcinoma in situ without an identifiable invasive component
• Plan for radiotherapy in continuous course
• Prior surgical exploration with gross residual disease remaining allowed
• Prior neck dissection with or without biopsy of primary tumor, but no radical surgery for primary tumor, allowed
• Anemia, defined as hemoglobin no greater than 13.5 g/dL for males and no greater than 12.5 g/dL for females (transfusion prior to study allowed)
• No severe anemia (i.e., hemoglobin less than 9.0 g/dL)
• No anemia confirmed to be due to causes other than chronic disease (e.g., iron deficiency anemia)
• Not entered on other RTOG head and neck protocols

PATIENT CHARACTERISTICS: Age:

• 18 and over

Performance status:

• Zubrod 0-2

Life expectancy:

• Not specified

Hematopoietic:

• See Disease Characteristics
• Stage III/IV patients receiving concurrent cisplatin:
• Absolute neutrophil count at least 2,000/mm^3
• Platelet count at least 100,000/mm^3

Hepatic:

• Not specified

Renal:

• Stage III/IV patients receiving concurrent cisplatin:
• Creatinine no greater than 1.5 mg/dL
• Creatinine clearance at least 50 mL/min

Cardiovascular:

• No malignant or poorly controlled hypertension (e.g., symptomatic hypertension or diastolic blood pressure of 100 mm Hg or greater despite antihypertensive medication)
• No unstable angina or other poorly controlled cardiac disease

Other:

• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• If stage III or IV disease is present, willing to come for twice daily radiotherapy for the last 2.5 weeks of therapy
• No active infection requiring IV antibiotics
• No unexplained fever
• No AIDS or other history of congenital or acquired immunodeficiency
• No other malignancies within the past 3 years except carcinoma in situ or nonmelanomatous skin cancer
• No known hypersensitivity to mammalian cell-derived products or to human albumin
• No acute/subacute illness that would make the need for transfusion likely

PRIOR CONCURRENT THERAPY: Biologic therapy:

• At least 4 weeks since other prior cytokine therapy (e.g., filgrastim [G-CSF], interleukins, or interferons)
• No prior epoetin alfa
• No other concurrent cytokine therapy

Chemotherapy:

• No prior chemotherapy
• Concurrent cisplatin, paclitaxel/cisplatin, or paclitaxel/carboplatin for patients with stage III/IV disease is allowed

Endocrine therapy:

• Not specified

Radiotherapy:

• See Disease Characteristics
• No prior radiotherapy to the head and neck

Surgery:

• See Disease Characteristics

Other:

• No concurrent amifostine
• No concurrent transfusion

Alabama
      Alabama Oncology, LLC, Montgomery,  Alabama,  36106-3657,  United States
      Comprehensive Cancer Institute of Huntsville, Huntsville,  Alabama,  35801,  United States
      DCH Cancer Treatment Center, Tuscaloosa,  Alabama,  35401,  United States
      Huntsville Hospital System, Huntsville,  Alabama,  35807,  United States
      MBCCOP - Gulf Coast, Mobile,  Alabama,  36688,  United States
      University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham,  Alabama,  35294-3300,  United States
Arizona
      Foundation for Cancer Research and Education, Phoenix,  Arizona,  85013,  United States
California
      California Cancer Center, Fresno,  California,  93720,  United States
      CCOP - Bay Area Tumor Institute, Oakland,  California,  94609-3305,  United States
      CCOP - Santa Rosa Memorial Hospital, Santa Rosa,  California,  95403,  United States
      City of Hope Comprehensive Cancer Center, Duarte,  California,  91010-3000,  United States
      David Grant Medical Center, Travis Air Force Base,  California,  94535,  United States
      Huntington Cancer Center, Pasadena,  California,  91105,  United States
      Jonsson Comprehensive Cancer Center, UCLA, Los Angeles,  California,  90095-1714,  United States
      Loma Linda University Medical Center, Loma Linda,  California,  92354,  United States
      Mount Diablo Medical Center, Concord,  California,  94524-4110,  United States
      Naval Medical Center - San Diego, San Diego,  California,  92134-3202,  United States
      O'Connor Hospital, San Jose,  California,  95128,  United States
      Providence Saint Joseph Medical Center - Burbank, Burbank,  California,  91505,  United States
      Radiation Medical Group, Incorporated, San Diego,  California,  92101,  United States
      Radiation Oncology Center - Sacramento, Sacramento,  California,  95816,  United States
      Robert and Beverly Lewis Family Cancer Care Center, Pomona,  California,  91767,  United States
      Saint Agnes Cancer Center, Fresno,  California,  93720,  United States
      Sutter Health Western Division Cancer Research Group, Greenbrae,  California,  94904,  United States
      Torrance Memorial Medical Center, Torrance,  California,  90505,  United States
      UCSF Comprehensive Cancer Center, San Francisco,  California,  94143-0128,  United States
      USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles,  California,  90033-0804,  United States
      Veterans Affairs Medical Center - Long Beach, Long Beach,  California,  90822,  United States
Colorado
      CCOP - Colorado Cancer Research Program, Incorporated, Denver,  Colorado,  80224,  United States
      Memorial Hospital Cancer Center, Colorado Springs,  Colorado,  80909,  United States
      Saint Mary's Hospital and Medical Center, Grand Junction,  Colorado,  81502-1628,  United States
      University of Colorado Cancer Center, Denver,  Colorado,  80010,  United States
Connecticut
      Yale Comprehensive Cancer Center, New Haven,  Connecticut,  06520-8040,  United States
Delaware
      CCOP - Christiana Care Health Services, Newark,  Delaware,  19713,  United States
District of Columbia
      Sibley Memorial Hospital, Washington,  District of Columbia,  20016,  United States
Florida
      21st Century Oncology - Fort Myers, Fort Myers,  Florida,  33901-8082,  United States
      Baptist Hospital of Miami, Miami,  Florida,  33256-2110,  United States
      Bay Medical Center, Panama City,  Florida,  32401,  United States
      CCOP - Mount Sinai Medical Center, Miami Beach,  Florida,  33140,  United States
      Florida Radiation Oncology Group, Jacksonville,  Florida,  32207,  United States
      Gulf Coast Cancer Treatment Center, Panama City,  Florida,  32405-4587,  United States
      H. Lee Moffitt Cancer Center and Research Institute, Tampa,  Florida,  33612-9497,  United States
      Holmes Regional Medical Center, Melbourne,  Florida,  32901-3276,  United States
      MD Anderson Cancer Center Orlando, Orlando,  Florida,  32806-2134,  United States
      Sarasota Radiation and Medical Oncology Center, Sarasota,  Florida,  34233,  United States
      Sylvester Cancer Center, University of Miami, Miami,  Florida,  33136,  United States
      Tallahassee Memorial Healthcare, Tallahassee,  Florida,  32308,  United States
      University of Florida Health Science Center, Gainesville,  Florida,  32610-0385,  United States
      Veterans Affairs Medical Center - Miami, Miami,  Florida,  33125,  United States
Georgia
      CCOP - Atlanta Regional, Atlanta,  Georgia,  30342-1701,  United States
      Emory University Hospital - Atlanta, Atlanta,  Georgia,  30322,  United States
      Medical Center/John B. Amos Community Cancer Center, Columbus,  Georgia,  31901,  United States
      Regional Radiation Oncology Center at Rome, Rome,  Georgia,  30165,  United States
Hawaii
      MBCCOP - Hawaii, Honolulu,  Hawaii,  96813,  United States
Illinois
      CCOP - Central Illinois, Decatur,  Illinois,  62526,  United States
      CCOP - Scott and White Hospital, Peoria,  Illinois,  61602,  United States
      Ingalls Memorial Hospital, Harvey,  Illinois,  60426,  United States
      Loyola University Medical Center, Maywood,  Illinois,  60153,  United States
      Lutheran General Cancer Care Center, Park Ridge,  Illinois,  60068,  United States
      Methodist Medical Center of Illinois, Peoria,  Illinois,  61636,  United States
      Northwest Community Hospital, Arlington Heights,  Illinois,  60005,  United States
      Northwestern Memorial Hospital, Chicago,  Illinois,  60611,  United States
Indiana
      Ball Memorial Hospital, Muncie,  Indiana,  47303-3499,  United States
      Bloomington Hospital, Bloomington,  Indiana,  47402,  United States
      CCOP - Northern Indiana CR Consortium, South Bend,  Indiana,  46601,  United States
      Clarian Health Partners Inc., Indianapolis,  Indiana,  46206-1367,  United States
      Community Regional Cancer Care, Indianapolis,  Indiana,  46219,  United States
      St. John's Medical Center, Anderson,  Indiana,  46016,  United States
      Veterans Affairs Medical Center - Indianapolis (Roudebush), Indianapolis,  Indiana,  46202,  United States
Iowa
      Wendt Regional Cancer Center of Finley Hospital, Dubuque,  Iowa,  52001,  United States
Kentucky
      Albert B. Chandler Medical Center, University of Kentucky, Lexington,  Kentucky,  40536-0293,  United States
      Cancer Center at Lexington Clinic, Lexington,  Kentucky,  40504,  United States
      Central Baptist Hospital, Lexington,  Kentucky,  40503,  United States
      James Graham Brown Cancer Center, Louisville,  Kentucky,  40202,  United States
      Louisville Radiation Oncology, Louisville,  Kentucky,  40215,  United States
      Merle M. Mahr Cancer Center, Madisonville,  Kentucky,  42431,  United States
      St. Elizabeth Medical Center, Edgewood,  Kentucky,  41017,  United States
Louisiana
      CCOP - Ochsner, New Orleans,  Louisiana,  70121,  United States
      Mary Bird Perkins Cancer Center, Baton Rouge,  Louisiana,  70809,  United States
      MBCCOP - LSU Health Sciences Center, New Orleans,  Louisiana,  70112,  United States
      Tulane University School of Medicine, New Orleans,  Louisiana,  70112-2699,  United States
Maine
      Maine Medical Center, Portland,  Maine,  04102,  United States
Maryland
      Anne Arundel Oncology Center, Annapolis,  Maryland,  21401,  United States
      Greater Baltimore Medical Center and Cancer Center, Baltimore,  Maryland,  21204,  United States
      Harbor Hospital Center, Baltimore,  Maryland,  21215-1290,  United States
      Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore,  Maryland,  21201,  United States
      Peninsula Regional Medical Center, Salisbury,  Maryland,  21801,  United States
      Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore,  Maryland,  21231-2410,  United States
      Sinai Hospital of Baltimore, Baltimore,  Maryland,  21215,  United States
      St. Agnes Cancer Center, Baltimore,  Maryland,  21229,  United States
Massachusetts
      Boston Medical Center, Boston,  Massachusetts,  02118,  United States
      Cape Cod Hospital, Hyannis,  Massachusetts,  02601,  United States
      Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston,  Massachusetts,  02114,  United States
      NSMC Cancer Center, Peabody,  Massachusetts,  01960,  United States
      Veterans Affairs Medical Center - Boston (Jamaica Plain), Jamaica Plain,  Massachusetts,  02130,  United States
Michigan
      Barbara Ann Karmanos Cancer Institute, Detroit,  Michigan,  48201-1379,  United States
      CCOP - Beaumont, Royal Oak,  Michigan,  48073-6769,  United States
      CCOP - Kalamazoo, Kalamazoo,  Michigan,  49007-3731,  United States
      CCOP - Michigan Cancer Research Consortium, Ann Arbor,  Michigan,  48106,  United States
      Henry Ford Hospital, Detroit,  Michigan,  48202,  United States
      Hurley Medical Center, Flint,  Michigan,  48503,  United States
      Marquette General Hospital, Marquette,  Michigan,  49855,  United States
      McLaren Regional Cancer Center, Flint,  Michigan,  48532-3685,  United States
      MidMichigan Medical Center - Midland, Midland,  Michigan,  48670,  United States
      University of Michigan Comprehensive Cancer Center, Ann Arbor,  Michigan,  48109-0010,  United States
      William Beaumont Hospital - Troy, Troy,  Michigan,  48098,  United States
      William Beaumont Hospital, Royal Oak,  Michigan,  48073,  United States
Minnesota
      CCOP - Metro-Minnesota, Saint Louis Park,  Minnesota,  55416,  United States
      Fairview University Medical Center, Minneapolis,  Minnesota,  55455,  United States
      Mayo Clinic Cancer Center, Rochester,  Minnesota,  55905-0001,  United States
Missouri
      Cancer Research for the Ozarks, Springfield,  Missouri,  65807,  United States
      CCOP - Cancer Research for the Ozarks, Springfield,  Missouri,  65807,  United States
      CCOP - Kansas City, Kansas City,  Missouri,  64131,  United States
      Ellis Fischel Cancer Center - Columbia, Columbia,  Missouri,  65203,  United States
      Mallinckrodt Institute of Radiology, Saint Louis,  Missouri,  63108,  United States
      St. Louis University Health Sciences Center, Saint Louis,  Missouri,  63110-0250,  United States
Montana
      CCOP - Montana Cancer Consortium, Billings,  Montana,  59101,  United States
Nebraska
      CCOP - Missouri Valley Cancer Consortium, Omaha,  Nebraska,  68106,  United States
      Methodist Hospital Cancer Center - Omaha, Omaha,  Nebraska,  68114,  United States
      Nebraska Health System, Omaha,  Nebraska,  68198-7460,  United States
Nevada
      CCOP - Southern Nevada Cancer Research Foundation, Las Vegas,  Nevada,  89106,  United States
      Comprehensive Cancer Centers of Nevada, Las Vegas,  Nevada,  89109,  United States
New Hampshire
      Elliot Regional Cancer Center, Manchester,  New Hampshire,  03103,  United States
      Norris Cotton Cancer Center, Lebanon,  New Hampshire,  03756-0002,  United States
New Jersey
      Associated Radiologists, P.A., Warren,  New Jersey,  07059,  United States
      Atlantic City Medical Center, Pomona,  New Jersey,  08240,  United States
      Cancer Institute of New Jersey, New Brunswick,  New Jersey,  08903,  United States
      Community Medical Center, Toms River,  New Jersey,  08755,  United States
      Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital, Mount Holly,  New Jersey,  08060,  United States
      John F. Kennedy Medical Center, Edison,  New Jersey,  08818,  United States
      Medical Center of Princeton, Princeton,  New Jersey,  08540,  United States
      Monmouth Medical Center, Long Branch,  New Jersey,  07740-6395,  United States
      Newark Beth Israel Medical Center, Newark,  New Jersey,  07112,  United States
      South Jersey Regional Cancer Center, Millville,  New Jersey,  08332,  United States
      St. Francis Medical Center, Trenton,  New Jersey,  08629,  United States
      Trinitas Hospital - Jersey Street Campus, Elizabeth,  New Jersey,  07201,  United States
      Valley Hospital, Ridgewood,  New Jersey,  07450,  United States
      Veterans Affairs Medical Center - East Orange, East Orange,  New Jersey,  07019,  United States
New Mexico
      Radiation Oncology Associates of Albuquerque, Albuquerque,  New Mexico,  87109,  United States
New York
      Beth Israel Medical Center, New York,  New York,  10003,  United States
      Cancer Center of Albany Medical Center, Albany,  New York,  12208,  United States
      CCOP - North Shore University Hospital, Manhasset,  New York,  11030,  United States
      CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C., Syracuse,  New York,  13217,  United States
      Champlain Valley Physicians Hospital Medical Center, Plattsburgh,  New York,  12901,  United States
      Finger Lakes Radiation Oncology Center, Clifton Springs,  New York,  14432,  United States
      Herbert Irving Comprehensive Cancer Center, New York,  New York,  10032,  United States
      James P. Wilmot Cancer Center, Rochester,  New York,  14642,  United States
      New York Methodist Hospital, Brooklyn,  New York,  11215,  United States
      Riverhill Radiation Oncology, Yonkers,  New York,  10701,  United States
      Roswell Park Cancer Institute, Buffalo,  New York,  14263-0001,  United States
      State University of New York Health Science Center at Brooklyn, Brooklyn,  New York,  11203,  United States
North Carolina
      CCOP - Southeast Cancer Control Consortium, Winston Salem,  North Carolina,  27104-4241,  United States
      Comprehensive Cancer Center at Wake Forest University, Winston Salem,  North Carolina,  27157-1082,  United States
      East Carolina University School of Medicine, Greenville,  North Carolina,  27858-4354,  United States
      Lineberger Comprehensive Cancer Center, UNC, Chapel Hill,  North Carolina,  27599-7295,  United States
      Northeast Medical Center, Concord,  North Carolina,  28025,  United States
North Dakota
      Trinity Cancer Care Center, Minot,  North Dakota,  58701,  United States
Ohio
      Akron City Hospital, Akron,  Ohio,  44304,  United States
      Akron General Medical Center, Akron,  Ohio,  44302,  United States
      Arthur G. James Cancer Hospital - Ohio State University, Columbus,  Ohio,  43210-1240,  United States
      Barrett Cancer Center, Cincinnati,  Ohio,  45219,  United States
      CCOP - Columbus, Columbus,  Ohio,  43206,  United States
      CCOP - Dayton, Dayton,  Ohio,  45429,  United States
      CCOP - Toledo Community Hospital, Toledo,  Ohio,  43623-3456,  United States
      Christ Hospital, Cincinnati,  Ohio,  45219,  United States
      Cleveland Clinic Taussig Cancer Center, Cleveland,  Ohio,  44195,  United States
      Ireland Cancer Center, Cleveland,  Ohio,  44106-5065,  United States
      Parma Community General Hospital, Parma,  Ohio,  44129,  United States
      University Hospitals of Cleveland, Cleveland,  Ohio,  44106,  United States
Oklahoma
      CCOP - Oklahoma, Tulsa,  Oklahoma,  74136,  United States
      St. Anthony Hospital, Oklahoma City,  Oklahoma,  73101,  United States
      St. John Health System, Tulsa,  Oklahoma,  74104,  United States
      University of Oklahoma Health Sciences Center, Oklahoma City,  Oklahoma,  73104,  United States
Oregon
      CCOP - Columbia River Oncology Program, Portland,  Oregon,  97225,  United States
Pennsylvania
      Abington Memorial Hospital, Abington,  Pennsylvania,  19001,  United States
      Abramson Cancer Center of the University of Pennsylvania, Philadelphia,  Pennsylvania,  19104-4283,  United States
      Albert Einstein Cancer Center, Philadelphia,  Pennsylvania,  19141-3098,  United States
      Allegheny General Hospital, Pittsburgh,  Pennsylvania,  15212,  United States
      CCOP - MainLine Health, Wynnewood,  Pennsylvania,  19096,  United States
      Delaware County Memorial Hospital, Drexel Hill,  Pennsylvania,  19026,  United States
      Fox Chase Cancer Center, Philadelphia,  Pennsylvania,  19111,  United States
      Geisinger Medical Center, Danville,  Pennsylvania,  17822-2001,  United States
      Kimmel Cancer Center of Thomas Jefferson University - Philadelphia, Philadelphia,  Pennsylvania,  19107-5541,  United States
      Lehigh Valley Hospital, Allentown,  Pennsylvania,  18105,  United States
      Mercy Fitzgerald Hospital, Darby,  Pennsylvania,  19023,  United States
      Mercy Hospital Cancer Center - Scranton, Scranton,  Pennsylvania,  18501,  United States
      Mercy Hospital of Pittsburgh, Pittsburgh,  Pennsylvania,  15219,  United States
      Milton S. Hershey Medical Center, Hershey,  Pennsylvania,  17033-0850,  United States
      Pocono Cancer Center, East Stroudsburg,  Pennsylvania,  18301,  United States
      Reading Hospital and Medical Center, Reading,  Pennsylvania,  19612-6052,  United States
      St. Luke's Hospital Cancer Center, Bethlehem,  Pennsylvania,  18015,  United States
      University of Pittsburgh Cancer Institute, Pittsburgh,  Pennsylvania,  15236,  United States
      Veterans Affairs Medical Center - Philadelphia, Philadelphia,  Pennsylvania,  19104,  United States
      Western Pennsylvania Hospital, Pittsburgh,  Pennsylvania,  15224,  United States
      Wilkes Barre General Hospital, Wilkes Barre,  Pennsylvania,  18764,  United States
      York Cancer Center, York,  Pennsylvania,  17403,  United States
Rhode Island
      Roger Williams Medical Center/BUSM, Providence,  Rhode Island,  02908-4735,  United States
South Carolina
      CCOP - Greenville, Greenville,  South Carolina,  29615,  United States
      CCOP - Upstate Carolina, Spartanburg,  South Carolina,  29303,  United States
South Dakota
      Rapid City Regional Hospital, Rapid City,  South Dakota,  57709,  United States
Tennessee
      Jackson-Madison County General Hospital, Jackson,  Tennessee,  38301-3956,  United States
      University of Tennessee Cancer Institute, Memphis,  Tennessee,  38103,  United States
      Vanderbilt-Ingram Cancer Center, Nashville,  Tennessee,  37232-5671,  United States
Texas
      Arlington Cancer Center, Arlington,  Texas,  76012,  United States
      Bayshore Medical Center, Pasadena,  Texas,  77504,  United States
      Harrington Cancer Center, Amarillo,  Texas,  79106,  United States
      Joe Arrington Cancer Research and Treatment Center, Lubbock,  Texas,  79410-1894,  United States
      University of Texas - MD Anderson Cancer Center, Houston,  Texas,  77030-4009,  United States
      University of Texas Health Science Center at San Antonio, San Antonio,  Texas,  78284-7811,  United States
      University of Texas Medical Branch, Galveston,  Texas,  77555-0209,  United States
      Wilford Hall Medical Center, Lackland Air Force Base,  Texas,  78236-5300,  United States
Utah
      Dixie Regional Medical Center, Saint George,  Utah,  84770,  United States
      Latter Day Saints Hospital, Salt Lake City,  Utah,  84143,  United States
      University of Utah Health Sciences Center, Salt Lake City,  Utah,  84132,  United States
      Utah Valley Regional Medical Center - Provo, Provo,  Utah,  84604,  United States
Vermont
      Green Mountain Oncology Group, Bennington,  Vermont,  05201,  United States
      Vermont Cancer Center, Burlington,  Vermont,  05405-0075,  United States
Virginia
      Bon Secours - St. Mary's Hospital, Richmond,  Virginia,  23226,  United States
      Cancer Center at the University of Virginia, Charlottesville,  Virginia,  22908,  United States
      Massey Cancer Center, Richmond,  Virginia,  23298-0058,  United States
      Naval Medical Center, Portsmouth, Portsmouth,  Virginia,  23708-2197,  United States
      RMH Regional Cancer Center, Harrisonburg,  Virginia,  22801,  United States
Washington
      Deaconess Medical Center, Spokane,  Washington,  99204,  United States
      University of Washington Medical Center, Seattle,  Washington,  98195-6043,  United States
      Virginia Mason Medical Center, Seattle,  Washington,  98111,  United States
      Yakima Valley Memorial Hospital, Yakima,  Washington,  98902,  United States
West Virginia
      Schiffler Cancer Center, Wheeling,  West Virginia,  26003,  United States
Wisconsin
      All Saints Cancer Center, Racine,  Wisconsin,  53405,  United States
      CCOP - St. Vincent Hospital Cancer Center, Green Bay, Green Bay,  Wisconsin,  54301,  United States
      Columbia Hospital, Milwaukee,  Wisconsin,  53211,  United States
      Community Memorial Hospital, Menomonee Falls,  Wisconsin,  53051,  United States
      Gundersen Lutheran Medical Foundation, La Crosse,  Wisconsin,  54601,  United States
      Marshfield Clinic, Marshfield,  Wisconsin,  54449,  United States
      Medical College of Wisconsin Cancer Center, Milwaukee,  Wisconsin,  53226,  United States
      Southern Wisconsin Radiotherapy Center, Madison,  Wisconsin,  53713,  United States
      St. Luke's Medical Center, Milwaukee,  Wisconsin,  53215,  United States
      St. Vincent Hospital, Green Bay,  Wisconsin,  54307-3508,  United States
      University of Wisconsin Comprehensive Cancer Center, Madison,  Wisconsin,  53792,  United States
      Veterans Affairs Medical Center - Milwaukee (Zablocki), Milwaukee,  Wisconsin,  53295,  United States
      Waukesha Memorial Hospital Regional Cancer Center, Waukesha,  Wisconsin,  53188,  United States
Canada, Alberta
      Cross Cancer Institute, Edmonton,  Alberta,  T6G 1Z2,  Canada
      Tom Baker Cancer Center - Calgary, Calgary,  Alberta,  T2N 4N2,  Canada
Canada, New Brunswick
      Doctor Leon Richard Oncology Centre, Moncton,  New Brunswick,  E1C 8X3,  Canada
      Saint John Regional Hospital, Saint John,  New Brunswick,  E2L 4L2,  Canada
Canada, Newfoundland and Labrador
      Newfoundland Cancer Treatment and Research Foundation, St. Johns,  Newfoundland and Labrador,  A1B 3V6,  Canada
Canada, Nova Scotia
      Nova Scotia Cancer Centre, Halifax,  Nova Scotia,  B3H 1V7,  Canada
Canada, Ontario
      Cancer Care Ontario-Hamilton Regional Cancer Centre, Hamilton,  Ontario,  L8V 5C2,  Canada
      Cancer Care Ontario-London Regional Cancer Centre, London,  Ontario,  N6A 4L6,  Canada
      Kingston Regional Cancer Centre, Kingston,  Ontario,  K7L 5P9,  Canada
      Northeastern Ontario Regional Cancer Centre, Sudbury, Sudbury,  Ontario,  P3E 5J1,  Canada
      Northwestern Ontario Regional Cancer Centre, Thunder Bay, Thunder Bay,  Ontario,  P7A 7T1,  Canada
      Ottawa Regional Cancer Centre, Ottawa,  Ontario,  K1H 1C4,  Canada
      Princess Margaret Hospital, Toronto,  Ontario,  M5G 2M9,  Canada
      Toronto Sunnybrook Regional Cancer Centre, Toronto,  Ontario,  M4N 3M5,  Canada
Canada, Quebec
      Centre Hospitalier de l'Universite de Montreal, Montreal,  Quebec,  H2L 4MI,  Canada
      Centre Hospitalier Universitaire de Quebec, Quebec City,  Quebec,  G1R 2J6,  Canada
      CHUS-Hopital Fleurimont, Fleurimont,  Quebec,  J1H 5N4,  Canada
      McGill University, Montreal,  Quebec,  H2W 1S6,  Canada
Canada, Saskatchewan
      Allan Blair Cancer Centre, Regina,  Saskatchewan,  S4T 7T1,  Canada
      Saskatoon Cancer Centre, Saskatoon,  Saskatchewan,  S7N 4H4,  Canada
Korea, Republic of
      Jin Soo Lee Practice Inc., Gyeonggi,  411-764,  Korea, Republic of

Study chairs or principal investigators

Mitchell Machtay, MD,  Study Chair,  University of Pennsylvania Cancer Center   

Study ID Numbers:  CDR0000067599; RTOG-9903; RTOG-DEV-1008
Record last reviewed:  February 2005
Last Updated:  February 23, 2005
Record first received:  March 7, 2000
ClinicalTrials.gov Identifier:  NCT00004917
Health Authority: Unspecified
ClinicalTrials.gov processed this record on 2005-04-08