Not Signed In -
Fallot's Tetralogy |
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Clinical Trial: Study of the Relationship Between Calcium Levels and Intact Parathyroid Hormone (iPTH) in Adults with Repaired or Palliated Conotruncal Cardiac Defects
This study has been completed.
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Purpose
OBJECTIVES: I. Identify latent hypoparathyroidism in normocalcemic adult survivors with repaired conotruncal cardiac defects, by evaluating parathyroid gland secretory function after induced hypocalcemia. II. Determine the relationship of parathyroid hormone secretion to microdeletions in the same region of chromosome 22q11 as found in patients with DiGeorge anomaly.
| Condition | Treatment or Intervention |
|---|---|
| Hypoparathyroidism Tetralogy of Fallot Pulmonary Valve Stenosis Conotruncal Cardiac Defects Heart Defects, Congenital Pulmonary Atresia | Drug: calcium gluconate Drug: sodium citrate |
MedlinePlus related topics: Birth Defects; Congenital Heart Disease; Heart Diseases; Heart Valve Diseases; Parathyroid Disorders; Vascular Diseases
Study Type: Observational
Study Design: Screening
Expected Total Enrollment: 150
Study start: July 1995
PROTOCOL OUTLINE: Patients are given sodium citrate over a 2 hour infusion on day 1. Blood is drawn at times -30, -15, 0, and every 10 minutes thereafter during the infusion. On day 2, patients are given calcium gluconate over a 2 hour infusion. Blood is drawn at times -30, -15, 0, and every 10 minutes thereafter during the infusion.
Eligibility
Ages Eligible for Study: 18 Years and above, Genders Eligible for Study: Both
Criteria
- Diagnostically shown repaired or palliated conotruncal cardiac defects, including tetralogy of Fallot with pulmonary stenosis or pulmonary atresia, truncus arteriosus, or interrupted aortic arch type B
Location Information
Craig B. Langman, Study Chair, Children's Memorial Hospital, Chicago
More Information
Record last reviewed: January 2001
Last Updated: October 13, 2004
Record first received: October 18, 1999
ClinicalTrials.gov Identifier: NCT00004361
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 9, 2005
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