Not Signed In -
Gender And Gender Bias/gender Differences |
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Clinical Trial: Gender Differences in Familial Risk
This study has been completed.
Purpose
To develop, test, and apply comprehensive mathematical models for the interaction of genetic and environmental effect on cardiovascular risk with gender differences.
| Condition |
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| Cardiovascular Diseases Heart Diseases |
MedlinePlus related topics: Heart Diseases; Heart Diseases--Prevention; Vascular Diseases
Study Type: Observational
Study Design: Natural History
Study start: February 1993; Study completion: January 1996
DESIGN NARRATIVE: Models were developed which allowed for sex difference in the expression of autosomal polygenes, differences in the impact of the paternal and maternal environment on male and female offspring, and for the complex consequences of assortative mating on the correlations among loci and between genes and environment. Computer simulations were used to decide which kinds of gender-dependent effects could be resolved with particular constellations of relatives, and to address problems of power and bias resulting from errors of model-specification. The methods developed were applied to data from extensive data already gathered from twins and their relatives to determine the importance of sex differences in genetic and environmental causes of variation in measured aspects of cardiovascular risk including weight, body-mass index, family history of CV disease, smoking, alcohol consumption, exercise, diet, psychosocial variables and lifestyle.
Eligibility
Genders Eligible for Study: Male
Criteria
More Information
Publications
Loos R, Thomis M, Maes HH, Beunen G, Claessens AL, Derom C, Legius E, Derom R, Vlietinck R. Gender-specific regional changes in genetic structure of muscularity in early adolescence. J Appl Physiol. 1997 Jun;82(6):1802-10.
Thomis MA, Van Leemputte M, Maes HH, Blimkie CJ, Claessens AL, Marchal G, Willems E, Vlietinck RF, Beunen GP. Multivariate genetic analysis of maximal isometric muscle force at different elbow angles. J Appl Physiol. 1997 Mar;82(3):959-67.
Maes HH, Beunen GP, Vlietinck RF, Neale MC, Thomis M, Vanden Eynde B, Lysens R, Simons J, Derom C, Derom R. Inheritance of physical fitness in 10-yr-old twins and their parents. Med Sci Sports Exerc. 1996 Dec;28(12):1479-91.
Eaves LJ, Neale MC, Maes H. Multivariate multipoint linkage analysis of quantitative trait loci. Behav Genet. 1996 Sep;26(5):519-25.
Meyer JM, Han J, Singh R, Moxley G. Sex influences on the penetrance of HLA shared-epitope genotypes for rheumatoid arthritis. Am J Hum Genet. 1996 Feb;58(2):371-83.
Neale MC, Eaves LJ, Kendler KS. The power of the classical twin study to resolve variation in threshold traits. Behav Genet. 1994 May;24(3):239-58.
Neale MC, Walters EE, Eaves LJ, Maes HH, Kendler KS. Multivariate genetic analysis of twin-family data on fears: Mx models. Behav Genet. 1994 Mar;24(2):119-39.
Eaves LJ. Effect of genetic architecture on the power of human linkage studies to resolve the contribution of quantitative trait loci. Heredity. 1994 Feb;72 ( Pt 2):175-92.
Record last reviewed: May 2000
Last Updated: October 13, 2004
Record first received: May 25, 2000
ClinicalTrials.gov Identifier: NCT00005355
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 9, 2005
Resources
- Alcohol Alert #46: Are Women More Vulnerable to Alcohol’s Effects? (National Institute on Alcohol Abuse and Alcoholism)
- Exploring the Biological Contributions to Human Health: Does Sex Matter? (National Academy Press)
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