RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies such as bevacizumab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Bevacizumab may also stop the growth of tumor cells by stopping blood flow to the tumor. Giving chemotherapy together with bevacizumab may kill more tumor cells. It is not yet known whether treatment with oxaliplatin, leucovorin, and fluorouracil is more effective with or without bevacizumab in treating patients who have undergone surgery for colon cancer.

PURPOSE: This randomized phase III trial is studying giving oxaliplatin, leucovorin, and fluorouracil together with bevacizumab to see how well it works compared to oxaliplatin, leucovorin, and fluorouracil alone in treating patients who have undergone surgery for stage II or stage III colon cancer.

Condition	Treatment or Intervention	Phase
adenocarcinoma of the colon stage II colon cancer stage III colon cancer	Drug: bevacizumab  Drug: fluorouracil  Drug: leucovorin calcium  Drug: oxaliplatin  Procedure: adjuvant therapy  Procedure: anti-cytokine therapy  Procedure: antiangiogenesis therapy  Procedure: antibody therapy  Procedure: biological response modifier therapy  Procedure: chemotherapy  Procedure: growth factor antagonist therapy  Procedure: monoclonal antibody therapy	Phase III

Further Study Details: 

OBJECTIVES: Primary

• Compare disease-free survival of patients with resected stage II or III adenocarcinoma of the colon treated with adjuvant chemotherapy comprising fluorouracil, leucovorin calcium, and oxaliplatin with vs without bevacizumab.

Secondary

• Compare overall survival of patients treated with these regimens.

Tertiary

• Determine the persistence of proteinuria after completion of bevacizumab in patients treated with bevacizumab.
• Correlate the development of proteinuria with clinical sequelae in patients treated with bevacizumab.
• Determine risk factors for development of proteinuria in patients treated with bevacizumab.
• Determine the effect of discontinuing bevacizumab on hypertension in these patients.
• Determine the incidence of delayed vascular events (e.g., myocardial infarction, CNS ischemia, and thrombosis) in patients treated with bevacizumab.
• Determine the effect of this drug on ovarian function in premenopausal women.
• Determine the incidence of immunogenicity and serum levels of bevacizumab in these patients.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to participating center and number of positive lymph nodes (0 vs 1-3 vs > 3). Patients are randomized to 1 of 2 treatment arms.

• Arm I: Patients receive adjuvant chemotherapy comprising concurrent oxaliplatin and leucovorin calcium IV over 2 hours on day 1. Patients also receive adjuvant fluorouracil IV over 2-4 minutes on day 1 followed by fluorouracil IV continuously over 46 hours on days 1 and 2. Treatment repeats every 14 days for 12 courses in the absence of disease progression or unacceptable toxicity.
• Arm II: Patients receive bevacizumab IV over 30-90 minutes on day 1. Patients also receive adjuvant oxaliplatin, leucovorin calcium, and fluorouracil as in arm I. Treatment repeats every 14 days for 12 courses in the absence of disease progression or unacceptable toxicity. After completion of adjuvant chemotherapy, patients continue to receive bevacizumab alone every 14 days for 6 months in the absence of disease progression or unacceptable toxicity. Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.

PROJECTED ACCRUAL: A total of 2,632 patients (1,316 per treatment arm) will be accrued for this study within 2.5 years.

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed adenocarcinoma of the colon, meeting 1 of the following stage criteria:
• Stage II disease (T3 or 4, N0, M0)
• Stage III disease (any T, N1 or 2, M0)
• No rectal tumors
• Distal extent of tumor ≥ 12 cm from the anal verge by endoscopy or surgical examination
• T4 tumors involving an adjacent structure (e.g., bladder, small intestine, or ovary) by direct extension from the primary tumor are eligible provided the following criteria are met:
• All or a portion of the adjacent structure was removed with the primary tumor
• All grossly visible tumor was completely resected (i.e., curative resection) in the opinion of the surgeon
• Margins of the resected specimen not involved with malignant cells by pathology
• Not planning local radiotherapy
• complete gross resection of tumor by open laparotomy or laparoscopically-assisted colectomy within the past 29-50 days
• Two-stage surgical procedure allowed (i.e., decompressive colostomy followed by definitive surgical resection)
• Patients with > 1 synchronous primary colon tumor are eligible
• Disease staging based on more advanced primary tumor
• No isolated, distant, or non-contiguous intra-abdominal metastases, even if resected

PATIENT CHARACTERISTICS: Age

• 18 and over

Performance status

• ECOG 0-1

Life expectancy

• At least 5 years

Hematopoietic

• Absolute granulocyte count ≥ 1,500/mm^3 (unless it represents an ethnic or racial variation of normal)
• Platelet count ≥ 100,000/mm^3
• No significant bleeding unrelated to the primary colon tumor within the past 6 months

Hepatic

• Bilirubin normal (unless due to slow conjugation of bilirubin caused by Gilbert's disease or a similar syndrome)
• Alkaline phosphatase < 2.5 times upper limit of normal (ULN)
• AST < 1.5 times ULN
• No PT (INR) > 1.5 unless patient is on full-dose anticoagulants AND the following criteria are met:
• INR 2-3 on a stable dose of warfarin or low molecular weight heparin
• No active bleeding
• No pathological condition associated with a high risk of bleeding
• No hepatic disease that would preclude study participation

Renal

• Creatinine ≤ 1.5 times ULN
• Urine protein/creatinine ratio < 1.0 OR
• < 1 g of protein on 24-hour urine collection
• No renal disease that would preclude study participation

Cardiovascular

• No uncontrolled blood pressure, defined as > 150/90 mm Hg
• No prior CNS cerebrovascular ischemia
• No peripheral arterial ischemia within the past 6 months
• Brief, reversible, exercise-induced claudication allowed
• No visceral arterial ischemia within the past 6 months
• No cardiovascular disease that would preclude study participation, including any of the following:
• New York Heart Association class III or IV myocardial disease
• Myocardial infarction within the past 6 months
• Unstable angina within the past 6 months
• Current symptomatic arrhythmia

Other

• No other malignancy within the past 5 years except effectively treated squamous cell or basal cell skin cancer, melanoma in situ, carcinoma in situ of the cervix, or carcinoma
• of the colon or rectum
• Must be at low risk of recurrence from any prior malignancy
• No serious or non-healing wound, skin ulcer, or bone fracture
• No active gastroduodenal ulcer by endoscopy
• No clinically significant peripheral neuropathy (i.e., neurosensory or neuromotor toxicity ≥ grade 2)
• No significant traumatic injury within the past 4 weeks
• No other nonmalignant systemic disease that would preclude study participation
• No psychiatric or addictive disorder or other condition that would preclude study participation
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• Patients randomized to receive bevacizumab must use effective contraception during and for 3 months after study treatment

PRIOR CONCURRENT THERAPY: Biologic therapy

• No concurrent prophylactic growth factors
• No concurrent biological response modifiers

Chemotherapy

• Not specified

Endocrine therapy

• Not specified

Radiotherapy

• See Disease Characteristics
• No prior radiotherapy for this malignancy
• No concurrent radiotherapy for this malignancy

Surgery

• See Disease Characteristics
• Recovered from prior surgery
• More than 4 weeks since prior major surgery or open biopsy
• More than 7 days since prior core biopsy or other minor surgery (except placement of a vascular access device)
• No concurrent major surgery

Other

• No prior systemic therapy for this malignancy
• No concurrent halogenated antiviral agents (e.g., sorivudine)
• No other concurrent investigational drugs
• No other concurrent antineoplastic agents

Alabama
      Huntsville Hospital, Huntsville,  Alabama,  35801,  United States; Recruiting
      Mobile Infirmary Medical Center, Mobile,  Alabama,  36652-2144,  United States; Recruiting
Arizona
      CCOP - Western Regional, Arizona, Phoenix,  Arizona,  85006-2726,  United States; Recruiting
Arkansas
      Hembree Mercy Cancer Center at St. Edward Mercy Medical Center, Fort Smith,  Arkansas,  72903,  United States; Recruiting
California
      Bay Area Tumor Institute, Oakland,  California,  94609,  United States; Recruiting
      Glendale Memorial Hospital and Health Center, Glendale,  California,  91204,  United States; Recruiting
      Joliet Oncology Hematology Associates, Limited - East, La Jolla,  California,  92037,  United States; Recruiting
      Kaiser Foundation Hospital - West Los Angeles, Los Angeles,  California,  90034,  United States; Recruiting
      Kaiser Permanente Medical Center - Hayward, Hayward,  California,  94545,  United States; Recruiting
      Kaiser Permanente Medical Center - Redwood City, Redwood City,  California,  94063,  United States; Recruiting
      Kaiser Permanente Medical Center - Roseville, Roseville,  California,  95661,  United States; Recruiting
      Kaiser Permanente Medical Center - Sacramento, Sacramento,  California,  95825,  United States; Recruiting
      Kaiser Permanente Medical Center - San Francisco French Campus, San Francisco,  California,  94118,  United States; Recruiting
      Kaiser Permanente Medical Center - Santa Clara, Santa Clara,  California,  95051-5386,  United States; Recruiting
      Kaiser Permanente Medical Center - Santa Rosa, Santa Rosa,  California,  95403,  United States; Recruiting
      Kaiser Permanente Medical Center - Santa Teresa, Santa Teresa,  California,  95119,  United States; Recruiting
      Kaiser Permanente Medical Center - South San Francisco, South San Francisco,  California,  94080,  United States; Recruiting
      Kaiser Permanente Medical Group, Panorama City,  California,  91402,  United States; Recruiting
      Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda,  California,  92354,  United States; Recruiting
      North Bay Cancer Center, Fairfield,  California,  94533,  United States; Recruiting
      Permanente Medical Group, San Jose,  California,  95119,  United States; Recruiting
      Providence Saint Joseph Medical Center - Burbank, Burbank,  California,  91505,  United States; Recruiting
      Santa Rosa Memorial Hospital, Santa Rosa,  California,  95405,  United States; Recruiting
      Stanford Cancer Center at Stanford University Medical Center, Stanford,  California,  94305,  United States; Recruiting
      Sutter Cancer Center, Sacramento,  California,  95816,  United States; Recruiting
      Sutter Roseville Medical Center, Roseville,  California,  95661,  United States; Recruiting
      Veterans Affairs Medical Center - Loma Linda (Pettis), Loma Linda,  California,  92357,  United States; Recruiting
Colorado
      Boulder Community Hospital, Boulder,  Colorado,  80301-9019,  United States; Recruiting
      CCOP - Colorado Cancer Research Program, Incorporated, Denver,  Colorado,  80224,  United States; Recruiting
      Exempla Lutheran Medical Center, Wheat Ridge,  Colorado,  80033,  United States; Recruiting
      Front Range Cancer Specialists, Fort Collins,  Colorado,  80524-4038,  United States; Recruiting
      McKee Medical Center, Loveland,  Colorado,  80538,  United States; Recruiting
      Medical Center of Aurora - South Campus, Aurora,  Colorado,  80012-0000,  United States; Recruiting
      North Suburban Medical Center, Thornton,  Colorado,  80229,  United States; Recruiting
      Penrose Cancer Center at Penrose Hospital, Colorado Springs,  Colorado,  80933,  United States; Recruiting
      Poudre Valley Hospital, Fort Collins,  Colorado,  80524,  United States; Recruiting
      Presbyterian - St. Luke's Medical Center, Denver,  Colorado,  80218,  United States; Recruiting
      Rose Medical Center, Denver,  Colorado,  80220,  United States; Recruiting
      Sky Ridge Medical Center, Lone Tree,  Colorado,  80124,  United States; Recruiting
      St. Mary-Corwin Regional Medical Center, Pueblo,  Colorado,  81004,  United States; Recruiting
      Swedish Medical Center, Englewood,  Colorado,  80113,  United States; Recruiting
Connecticut
      Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center, Farmington,  Connecticut,  06360-2875,  United States; Recruiting
      New Britain General Hospital, New Britain,  Connecticut,  06050,  United States; Recruiting
Delaware
      Beebe Medical Center, Lewes,  Delaware,  19958,  United States; Recruiting
      Helen F. Graham Cancer Center, Wilmington,  Delaware,  19809,  United States; Recruiting
      Nanticoke Memorial Hospital, Seaford,  Delaware,  19973,  United States; Recruiting
      St. Francis Hospital, Wilmington,  Delaware,  19805,  United States; Recruiting
District of Columbia
      Sibley Memorial Hospital, Washington,  District of Columbia,  20016,  United States; Recruiting
Florida
      Baptist Cancer Institute - Jacksonville, Jacksonville,  Florida,  32207,  United States; Recruiting
      CCOP - Mount Sinai Medical Center, Miami Beach,  Florida,  33140,  United States; Recruiting
      Ella Milbank Foshay Cancer Center at Jupiter Medical Center, Jupiter,  Florida,  33458,  United States; Recruiting
      Halifax Medical Center, Daytona Beach,  Florida,  32114,  United States; Recruiting
      Joe DiMaggio Children's Hospital at Memorial, Hollywood,  Florida,  33021,  United States; Recruiting
      Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital, Fort Lauderdale,  Florida,  33308,  United States; Recruiting
Georgia
      Charles B. Eberhart Cancer Center at DeKalb Medical Center, Decatur,  Georgia,  30033,  United States; Recruiting
      Northside Hospital Cancer Center, Atlanta,  Georgia,  30342-1611,  United States; Recruiting
      Phoebe Cancer Center at Phoebe Putney Memorial Hospital, Albany,  Georgia,  31701,  United States; Recruiting
      Piedmont Hospital, Atlanta,  Georgia,  30309,  United States; Recruiting
      Saint Joseph's Hospital of Atlanta, Atlanta,  Georgia,  30342-1701,  United States; Recruiting
      Southern Regional Medical Center, Riverdale,  Georgia,  30274-2600,  United States; Recruiting
      WellStar Cobb Hospital, Austell,  Georgia,  30106,  United States; Recruiting
      Wellstar Kennestone Hospital, Marietta,  Georgia,  30060,  United States; Recruiting
Hawaii
      Kapiolani Medical Center at Pali Momi, Aiea,  Hawaii,  96701,  United States; Recruiting
      OnCare Hawaii, Incorporated - Kuakini, Honolulu,  Hawaii,  96817,  United States; Recruiting
      OnCare Hawaii, Incorporated - Lusitana, Honolulu,  Hawaii,  96813,  United States; Recruiting
      Queen's Cancer Institute at Queen's Medical Center, Honolulu,  Hawaii,  96813,  United States; Recruiting
      St. Francis Medical Center, Honolulu,  Hawaii,  96817,  United States; Recruiting
      Straub Clinic and Hospital, Incorporated, Honolulu,  Hawaii,  96813,  United States; Recruiting
      University of Hawaii John A. Burns School of Medicine, Honolulu,  Hawaii,  96822,  United States; Recruiting
Idaho
      North Idaho Cancer Center, Coeur D Alene,  Idaho,  83814,  United States; Recruiting
Illinois
      Alexian Brothers Cancer Care Center, Elk Grove Village,  Illinois,  60007,  United States; Recruiting
      Carle Clinic Association, Urbana,  Illinois,  61801,  United States; Recruiting
      CCOP - Carle Cancer Center, Urbana,  Illinois,  61801,  United States; Recruiting
      Ingalls Cancer Care Center at Ingalls Memorial Hospital, Harvey,  Illinois,  60426,  United States; Recruiting
      Rush-Copley Cancer Care Center, Aurora,  Illinois,  60504-4206,  United States; Recruiting
      Saint Anthony's Hospital at Saint Anthony's Health Center, Alton,  Illinois,  62002,  United States; Recruiting
      St. Mary's Hospital, Decatur,  Illinois,  62521,  United States; Recruiting
      Swedish American Hospital, Rockford,  Illinois,  61104,  United States; Recruiting
      Swedish-American Regional Cancer Center, Rockford,  Illinois,  61104-2315,  United States; Recruiting
      Trinity Medical Center - East, Moline,  Illinois,  61265-1291,  United States; Recruiting
      West Suburban Center for Cancer Care, River Forest,  Illinois,  60305,  United States; Recruiting
Indiana
      CCOP - Northern Indiana CR Consortium, South Bend,  Indiana,  46601,  United States; Recruiting
      Center for Cancer Care at Goshen Health System, Goshen,  Indiana,  46526,  United States; Recruiting
      Center for Cancer Therapy at LaPorte Hospital and Health Services, LaPorte,  Indiana,  46350-0250,  United States; Recruiting
      Community Hospital, Munster,  Indiana,  46321,  United States; Recruiting
      Elkhart General Hospital, Elkhart,  Indiana,  46514-1329,  United States; Recruiting
      Elliot Regional Cancer Center, Elkhart,  Indiana,  46514-1329,  United States; Recruiting
      Memorial Hospital of South Bend, South Bend,  Indiana,  46601,  United States; Recruiting
      Porter Memorial Hospital, Valparaiso,  Indiana,  46383,  United States; Recruiting
      Saint Anthony Memorial Health Centers, Michigan City,  Indiana,  46360-4358,  United States; Recruiting
      St. Francis Hospital and Health Centers, Beech Grove,  Indiana,  46107,  United States; Recruiting
Iowa
      Cancer Center at Ottumwa Regional Health Center, Ottumwa,  Iowa,  52501,  United States; Recruiting
      CCOP - Iowa Oncology Research Association, Des Moines,  Iowa,  50309-1016,  United States; Recruiting
      Cedar Valley Medical Specialists, P.C. - West Ridgeway Avenue, Waterloo,  Iowa,  50701,  United States; Recruiting
      Covenant Medical Center, Waterloo,  Iowa,  50702,  United States; Recruiting
      Genesis Medical Center - West Campus, Davenport,  Iowa,  52804,  United States; Recruiting
      Genesis Regional Cancer Center at Genesis Medical Center, Davenport,  Iowa,  52803,  United States; Recruiting
      Iowa Blood and Cancer Care, Cedar Rapids,  Iowa,  52402-5057,  United States; Recruiting
      Iowa Clinic - Iowa Methodist Campus, Des Moines,  Iowa,  50309,  United States; Recruiting
      John Stoddard Cancer Center at Iowa Lutheran Hospital, Des Moines,  Iowa,  50316-2301,  United States; Recruiting
      McFarland Clinic, P.C., Ames,  Iowa,  50010,  United States; Recruiting
      Medical Oncology and Hematology Associates - West Des Moines, West Des Moines,  Iowa,  50266,  United States; Recruiting
      Medical Oncology and Hematology Associates at John Stoddard Cancer Center, Des Moines,  Iowa,  50309,  United States; Recruiting
      Medical Oncology and Hematology Associates at Mercy Cancer Center, Des Moines,  Iowa,  50314,  United States; Recruiting
      Mercy Cancer Center at Mercy Medical Center - Des Moines, Des Moines,  Iowa,  50314,  United States; Recruiting
      Mercy Cancer Center at Mercy Medical Center - North Iowa, Mason City,  Iowa,  50401,  United States; Recruiting
      Mercy Hospital, Iowa City,  Iowa,  52245,  United States; Recruiting
      St. Luke's Hospital, Cedar Rapids,  Iowa,  52406,  United States; Recruiting
Kansas
      Cancer Center at Stormont-Vail Regional Health Center, Topeka,  Kansas,  66606,  United States; Recruiting
      Cancer Center of Kansas, P.A. - El Dorado, El Dorado,  Kansas,  67042,  United States; Recruiting
      CCOP - Wichita, Wichita,  Kansas,  67214-3882,  United States; Recruiting
      Mount Carmel Regional Cancer Center, Pittsburg,  Kansas,  66762,  United States; Recruiting
      St. Francis Comprehensive Cancer Center, Topeka,  Kansas,  66606,  United States; Recruiting
      Via Christi Cancer Center at Via Christi Regional Medical Center, Wichita,  Kansas,  67214,  United States; Recruiting
Kentucky
      Baptist Hospital East - Louisville, Louisville,  Kentucky,  40207,  United States; Recruiting
Louisiana
      CCOP - Ochsner, New Orleans,  Louisiana,  70121,  United States; Recruiting
      Ochsner Cancer Institute at Ochsner Clinic Foundation, New Orleans,  Louisiana,  70121,  United States; Recruiting
      Tulane Cancer Center at Tulane University Hospital and Clinic, New Orleans,  Louisiana,  70112-2699,  United States; Recruiting
Maine
      York Hospital, York,  Maine,  03909-1099,  United States; Recruiting
Maryland
      Frederick Memorial Hospital Regional Cancer Therapy Center, Frederick,  Maryland,  21701,  United States; Recruiting
      Greater Baltimore Colorectal Specialists, Baltimore,  Maryland,  21204,  United States; Recruiting
      Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center, Baltimore,  Maryland,  21237,  United States; Recruiting
      St. Mary's Hospital, Leonardtown,  Maryland,  20650,  United States; Recruiting
      Suburban Hospital, Bethesda,  Maryland,  20814,  United States; Recruiting
      Union Hospital Cancer Center at Union Hospital, Elkton,  Maryland,  21921,  United States; Recruiting
Massachusetts
      Berkshire Medical Center, Pittsfield,  Massachusetts,  01201,  United States; Recruiting
      Cancer Research Center at Boston Medical Center, Boston,  Massachusetts,  02118,  United States; Recruiting
      Hudner Oncology Center at Saint Anne's Hospital, Fall River,  Massachusetts,  02721,  United States; Recruiting
      Jordan Hospital Club Cancer Center, Plymouth,  Massachusetts,  02360,  United States; Recruiting
      Lahey Clinic Medical Center - Burlington, Burlington,  Massachusetts,  01805,  United States; Recruiting
Michigan
      Battle Creek Health System, Battle Creek,  Michigan,  49016,  United States; Recruiting
      Borgess Medical Center, Kalamazoo,  Michigan,  49048-1666,  United States; Recruiting
      Bronson Methodist Hospital, Kalamazoo,  Michigan,  49007,  United States; Recruiting
      Grand Rapids Clinical Oncology, Grand Rapids,  Michigan,  49503,  United States; Recruiting
      Henry Ford Wyandotte Hospital, Wyandotte,  Michigan,  48192,  United States; Recruiting
      Holland Community Hospital, Holland,  Michigan,  49423,  United States; Recruiting
      Lacks Cancer Center at Saint Mary's Mercy Medical Center, Grand Rapids,  Michigan,  49503,  United States; Recruiting
      Mecosta County General Hospital, Big Rapids,  Michigan,  49307,  United States; Recruiting
      Mercy Memorial Hospital System, Monroe,  Michigan,  48162,  United States; Recruiting
      Metropolitan Hospital, Grand Rapids,  Michigan,  49506,  United States; Recruiting
      Munson Medical Center, Traverse City,  Michigan,  49684,  United States; Recruiting
      Northern Michigan Hospital, Petoskey,  Michigan,  49770,  United States; Recruiting
      Spectrum Health Cancer Care - Butterworth Campus, Grand Rapids,  Michigan,  49503,  United States; Recruiting
      Spectrum Health Hospital - Blodgett Campus, Grand Rapids,  Michigan,  49506,  United States; Recruiting
      West Michigan Cancer Center, Kalamazoo,  Michigan,  49007,  United States; Recruiting
Minnesota
      Cancer Care Center at Regions Hospital, Saint Paul,  Minnesota,  55101,  United States; Recruiting
      Cancer Care Center at St. Luke's Hospital, Duluth,  Minnesota,  55802,  United States; Recruiting
      CCOP - Metro-Minnesota, Saint Louis Park,  Minnesota,  55416,  United States; Recruiting
      Duluth Clinic - Hibbing, Hibbing,  Minnesota,  55746,  United States; Recruiting
      Fairview Ridges Hospital, Burnsville,  Minnesota,  55337,  United States; Recruiting
      Fairview Southdale Hospital, Edina,  Minnesota,  55435,  United States; Recruiting
      Hennepin County Medical Center - Minneapolis, Minneapolis,  Minnesota,  55415,  United States; Recruiting
      Hubert H. Humphrey Cancer Center at North Memorial Medical Center - Coon Rapids, Coon Rapids,  Minnesota,  55433,  United States; Recruiting
      Hutchinson Area Health Care, Hutchinson,  Minnesota,  55350,  United States; Recruiting
      Meeker County Memorial Hospital, Lichfield,  Minnesota,  55355,  United States; Recruiting
      Mercy and Unity Cancer Center at Mercy and Unity Hospitals, Fridley,  Minnesota,  55432-2799,  United States; Recruiting
      Mercy Hospital, Coon Rapids,  Minnesota,  55433,  United States; Recruiting
      Merit Care Clinic - Bemidji, Bemidji,  Minnesota,  56601,  United States; Recruiting
      Miller-Dwan Medical Center, Duluth,  Minnesota,  55805,  United States; Recruiting
      Park Nicollet Clinic, St. Louis Park,  Minnesota,  55416,  United States; Recruiting
      Ridgeview Medical Center, Waconia,  Minnesota,  55387,  United States; Recruiting
      Saint Francis Regional Medical Center, Shakopee,  Minnesota,  55379,  United States; Recruiting
      St. John's Hospital, Maplewood,  Minnesota,  55109,  United States; Recruiting
      St. Joseph's Hospital, Saint Paul,  Minnesota,  55102,  United States; Recruiting
      United Hospital, Saint Paul,  Minnesota,  55102,  United States; Recruiting
      Virginia Piper Cancer Institute at Abbott-Northwestern Hospital, Minneapolis,  Minnesota,  55407,  United States; Recruiting
Mississippi
      Hattiesburg Clinic, P.A., Hattiesburg,  Mississippi,  39401,  United States; Recruiting
      Hematology & Oncology Clinic, Hattiesburg,  Mississippi,  39402,  United States; Recruiting
Missouri
      CCOP - Cancer Research for the Ozarks, Springfield,  Missouri,  65807,  United States; Recruiting
      CCOP - Kansas City, Kansas City,  Missouri,  64131,  United States; Recruiting
      CCOP - St. Louis-Cape Girardeau, Saint Louis,  Missouri,  63141,  United States; Recruiting
      David C. Pratt Cancer Center at St. John's Mercy, Saint Louis,  Missouri,  63141,  United States; Recruiting
      Freeman Cancer Institute at Freeman Health System, Joplin,  Missouri,  64804,  United States; Recruiting
      Hulston Cancer Center at Cox Medical Center South, Springfield,  Missouri,  65807,  United States; Recruiting
      Saint Joseph Hospital, Saint Louis,  Missouri,  63122,  United States; Recruiting
      Saint Luke's Hospital, Chesterfield,  Missouri,  63017,  United States; Recruiting
      Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital, Cape Girardeau,  Missouri,  63701,  United States; Recruiting
      St. John's Regional Medical Center, Joplin,  Missouri,  64804,  United States; Recruiting
Montana
      Big Sky Oncology, Great Falls,  Montana,  59405,  United States; Recruiting
      CCOP - Montana Cancer Consortium, Billings,  Montana,  59101,  United States; Recruiting
Nebraska
      Bryan LGH Medical Center - East, Lincoln,  Nebraska,  68506,  United States; Recruiting
      Bryan LGH Medical Center West, Lincoln,  Nebraska,  68502-3780,  United States; Recruiting
      St. Elizabeth Regional Medical Center, Lincoln,  Nebraska,  68510,  United States; Recruiting
Nevada
      CCOP - Southern Nevada Cancer Research Foundation, Las Vegas,  Nevada,  89106,  United States; Recruiting
      University of Nevada School of Medicine, Reno,  Nevada,  89557-0046,  United States; Recruiting
New Jersey
      Cooper Cancer Institute at Cooper University Hospital, Voorhees,  New Jersey,  08043,  United States; Recruiting
      Newark Beth Israel Medical Center, Newark,  New Jersey,  07112,  United States; Recruiting
      South Jersey Hospital System - Elmer, Elmer,  New Jersey,  08318,  United States; Recruiting
      Trinitas Hospital - Jersey Street Campus, Elizabeth,  New Jersey,  07201,  United States; Recruiting
New Mexico
      Hematology-Oncology Associates, PC, Albuquerque,  New Mexico,  87106,  United States; Recruiting
      Lovelace Medical Center at Lovelace Sandia Health System, Albuquerque,  New Mexico,  87108,  United States; Recruiting
      New Mexico Cancer Care Associates, Santa Fe,  New Mexico,  87505-7670,  United States; Recruiting
      University of New Mexico Cancer Research and Treatment Center, Albuquerque,  New Mexico,  87131-5636,  United States; Recruiting
New York
      CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C., East Syracuse,  New York,  13057,  United States; Recruiting
      Charles R. Wood Cancer Center at Glens Falls Hospital, Glens Falls,  New York,  12801,  United States; Recruiting
North Carolina
      Rutherford Hospital, Rutherfordton,  North Carolina,  28139-0000,  United States; Recruiting
North Dakota
      Bismarck Cancer Center, Bismarck,  North Dakota,  58501-4445,  United States; Recruiting
      Medcenter One Health System, Bismarck,  North Dakota,  58501,  United States; Recruiting
      MeritCare Medical Group, Fargo,  North Dakota,  58103-2067,  United States; Recruiting
      Meritcare Roger Maris Cancer Center, Fargo,  North Dakota,  58122,  United States; Recruiting
      Mid Dakota Clinic, P.C., Bismarck,  North Dakota,  58501,  United States; Recruiting
      St. Alexius Medical Center, Bismarck,  North Dakota,  58502,  United States; Recruiting
Ohio
      Licking Memorial Cancer Care Program at Licking Memorial Hospital, Newark,  Ohio,  43055-2899,  United States; Recruiting
      Adena Regional Medical Center, Chillicothe,  Ohio,  45601,  United States; Recruiting
      Akron City Hospital at Summa Health System, Akron,  Ohio,  44309-2090,  United States; Recruiting
      Akron General's McDowell Cancer Center, Akron,  Ohio,  44302,  United States; Recruiting
      Aultman Hospital Cancer Center at Aultman Health Foundation, Canton,  Ohio,  44710-1799,  United States; Recruiting
      CCOP - Columbus, Columbus,  Ohio,  43206,  United States; Recruiting
      CCOP - Dayton, Dayton,  Ohio,  45429,  United States; Recruiting
      Community Hospital of Springfield and Clark County, Springfield,  Ohio,  45505,  United States; Recruiting
      Doctors Hospital at Ohio Health, Columbus,  Ohio,  43228,  United States; Recruiting
      Fairfield Medical Center, Lancaster,  Ohio,  43130,  United States; Recruiting
      Good Samaritan Hospital, Dayton,  Ohio,  45406-1891,  United States; Recruiting
      Grady Memorial Hospital, Delaware,  Ohio,  43015,  United States; Recruiting
      Grandview Hospital, Dayton,  Ohio,  45405,  United States; Recruiting
      MedCentral - Mansfield Hospital, Mansfield,  Ohio,  44903,  United States; Recruiting
      Miami Valley Hospital, Dayton,  Ohio,  45409,  United States; Recruiting
      Middletown Regional Hospital, Middletown,  Ohio,  45044-4898,  United States; Recruiting
      Mount Carmel West Hospital, Columbus,  Ohio,  43222,  United States; Recruiting
      Ruth G. McMillan Cancer Center at Greene Memorial Hospital, Xenia,  Ohio,  45385,  United States; Recruiting
      Samaritan North Cancer Care Center, Dayton,  Ohio,  45415,  United States; Recruiting
      Strecker Cancer Center at Marietta Memorial Hospital, Marietta,  Ohio,  45750-1635,  United States; Recruiting
      University Hospitals Ireland Cancer Center at Mercy Medical Center, Canton,  Ohio,  44708,  United States; Recruiting
Oklahoma
      LaFortune Cancer Center at St. John Health System, Tulsa,  Oklahoma,  74104,  United States; Recruiting
Oregon
      Bend Memorial Clinic, Bend,  Oregon,  97701-6099,  United States; Recruiting
      Comprehensive Cancer Center at Legacy Good Samaritan Hospital & Medical Center, Portland,  Oregon,  97210,  United States; Recruiting
      Legacy Emanuel Hospital and Health Center & Children's Hospital, Portland,  Oregon,  97227,  United States; Recruiting
      Legacy Meridian Park Hospital, Tualatin,  Oregon,  97062,  United States; Recruiting
      Legacy Mount Hood Medical Center, Gresham,  Oregon,  97030,  United States; Recruiting
      Providence Cancer Center at Providence Portland Medical Center, Portland,  Oregon,  97213-2967,  United States; Recruiting
      Providence Milwaukie Hospital, Milwaukie,  Oregon,  97222-6593,  United States; Recruiting
      Providence St. Vincent Medical Center, Portland,  Oregon,  97225,  United States; Recruiting
      St. Charles Medical Center, Bend,  Oregon,  97701,  United States; Recruiting
Pennsylvania
      Bryn Mawr Hospital, Bryn Mawr,  Pennsylvania,  19010,  United States; Recruiting
      Cancer Center at Paoli Memorial Hospital, Paoli,  Pennsylvania,  19301-1792,  United States; Recruiting
      CCOP - MainLine Health, Wynnewood,  Pennsylvania,  19096,  United States; Recruiting
      Central Pennsylvania Hematology and Medical Oncology Associates, PC, Lemoyne,  Pennsylvania,  17043-1440,  United States; Recruiting
      Ephrata Cancer Center at Ephrata Community Hospital, Ephrata,  Pennsylvania,  17522-1002,  United States; Recruiting
      Geisinger Medical Center, Danville,  Pennsylvania,  17822-2001,  United States; Recruiting
      Geisinger Medical Group, State College,  Pennsylvania,  16801,  United States; Recruiting
      Geisinger Wyoming Valley Medical Center, Wilkes Barre,  Pennsylvania,  18711,  United States; Recruiting
      Guthrie Medical Center - Sayre, Sayre,  Pennsylvania,  18840,  United States; Recruiting
      Hematology-Oncology Association of Northeastern Pennsylvania, Dunmore,  Pennsylvania,  18512,  United States; Recruiting
      Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia,  Pennsylvania,  19107-5541,  United States; Recruiting
      Lankenau Cancer Center at Lankenau Hospital, Wynnewood,  Pennsylvania,  19096,  Un

More Information

Clinical trial summary from the National Cancer Institute's PDQ® database

Source: ClinicalTrials.gov
Cache Date: April 9, 2005