GoldBamboo.com - Knowledge is strong medicine
  

The STOVITA-Study; Bioefficacy of Beta-Carotene in Oil and in a Mixed Diet in Ileostomy Patients - Article


  Not Signed In - Sign In / Register




General Topics A-Z

Ileostomy, Colostomy, and Ileoanal Reservoir Surgery

Clinical Trial: The STOVITA-Study; Bioefficacy of Beta-Carotene in Oil and in a Mixed Diet in Ileostomy Patients

This study has been completed.

Sponsors and Collaborators: Radboud University
Dutch Dairy Association
Information provided by: Radboud University
ClinicalTrials.gov Identifier: NCT00128804

Purpose

A controlled dietary intervention study will be carried out based on the stable isotope method we have developed to quantify both the absorption of beta-carotene and its bioconversion to retinol in oil and in mixed diet. During 4 weeks the participants will consume 2 capsules/d, 7 d/wk with each capsule containing 100-mg [13C10]beta-carotene and 100-mg [13C10]retinyl palmitate. Two weeks they will consume a diet with high levels of beta-carotene in the vegetables and fruits and the other 2 weeks they will consume a diet with low levels of beta-carotene in the vegetables and fruits supplemented with extra amount of beta-carotene in oil. Samples of blood and faeces will be taken. The study hypothesis is that the absorption of beta-carotene in oil in comparison with the absorption of beta-carotene in mixed diet differs a factor 3 to 6. We want to measure the influence of the food matrix of vegetables and fruits on the absorption of beta-carotene in ileostomy patients in a western diet.
Condition Intervention
Health
Ileostomy
  Behavior: absorption and conversion of beta-carotene in human GI tract

MedlinePlus consumer health information 

Study Type: Interventional
Study Design: Prevention, Randomized, Open Label, Dose Comparison, Crossover Assignment, Bio-availability Study

Official Title: Bioefficacy and Bioavailability of Beta-Carotene in Oil and in a Mixed Diet in Ileostomy Patients Measuring Using Specifically 13C-Labelled Beta-Carotene and Retinol

Further Study Details: 
Primary Outcomes: levels of retinol and carotenoids and the degree of isotopic enrichment in serum (fasting blood sample) and in faeces (72 h collection) at the start and at the end of the each of the 2-week periods
Expected Total Enrollment:  18

Study start: July 2004;  Study completion: August 2005
Last follow-up: October 2004;  Data entry closure: November 2004

Eligibility

Ages Eligible for Study:  18 Years   -   75 Years,  Genders Eligible for Study:  Both

Accepts Healthy Volunteers

Criteria

Inclusion Criteria:

  • men and women between 18 and 75 years old
  • BMI between 18 and 30 kg/m2
  • willing to consume the controlled diet and not consuming other food items
  • willing to consume the capsules every day
  • having an functional ileostomy (output <2 L/d)
  • relative good medical, nutritional and health status

Exclusion Criteria:

  • diseases which disturb normal digestion and absorption
  • use of (oral) drugs suspected of interfering with fat-soluble vitamin absorption
  • excessive alcohol consumption (>30 g/d)
  • consumption of vitamin or carotenoid supplements 6 wk before and during the study
  • not too low or high serum beta-carotene and retinol
  • normal hemoglobin, hemocytometry, creatinine, ALAT, alkalic phosphatase, cholesterol blood values (compared with laboratory references)
  • pregnancy

Location Information


Netherlands, Gelderland
      Radboud University Nijmegen Medical Centre, Nijmegen,  Gelderland,  6500HB,  Netherlands

Study chairs or principal investigators

Ton HJ Naber, MD PhD,  Study Director,  Radboud University   
Clive E West, PhD DSc,  Principal Investigator,  Radboud University   
Carolien A Bouwman, MSc,  Study Chair,  Radboud University   

More Information

Publications

van Lieshout M, West CE, Muhilal, Permaesih D, Wang Y, Xu X, van Breemen RB, Creemers AF, Verhoeven MA, Lugtenburg J. Bioefficacy of beta-carotene dissolved in oil studied in children in Indonesia. Am J Clin Nutr. 2001 May;73(5):949-58.

van Lieshout M, West CE, van Breemen RB. Isotopic tracer techniques for studying the bioavailability and bioefficacy of dietary carotenoids, particularly beta-carotene, in humans: a review. Am J Clin Nutr. 2003 Jan;77(1):12-28. Review.

Study ID Numbers:  STOVITA-2004-03-19-NZO; NZO-2002-07
Last Updated:  August 9, 2005
Record first received:  August 9, 2005
ClinicalTrials.gov Identifier:  NCT00128804
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)
ClinicalTrials.gov processed this record on 2005-08-23


Source: ClinicalTrials.gov
Cache Date: August 24, 2005


Take control over your directory listings...INSTANTLY

Every day, thousands of users find businesses like yours in the GoldBamboo directory.

Limited Time Offer!!!

For only $50 a year, a savings of 50% off our standard rate:

  • Edit your listing (whenever you want!)
  • Link to your website
  • Choose which categories you are listed in
  • Describe your services

The process will take only a few minutes and consists of 3 easy steps:

1. Register     >     2. Edit Listings     >     3. Publish

Your Company
your street
yourtown, YS 12345
888-888-8888



No Thanks

Popular Treatments

Acne Treatment ADHD Treatment Allergy Treatment Alzheimer's Treatment
Anemia Treatment Arthritis Treatment Asthma Treatment Bipolar Disorder Treatment
Bird Flu Treatment Bladder Cancer Treatment Bladder Control Treatment Blood Pressure Treatment
Brain Tumor Treatment Breast Cancer Treatment Bronchitis Treatment Cancer Treatment
Cancer Alternative Treatment Cataract Treatment Cirrhosis Treatment Colitis Treatment
Colon Cancer Treatment Common Cold Treatment Conjunctivitis Treatment Constipation Treatment
Crohn's Disease Treatment Cystic Fibrosis Treatment Depression Treatment Dermatitis Treatment
Diabetes Treatment Edema Treatment Epilepsy Treatment Erectile Dysfunction Treatment
Fibromyalgia Treatment GERD Treatment Glaucoma Treatment Gout Treatment
Hay Fever Treatment Headache Treatment Heart Disease Treatment Hepatitis Treatment
High Blood Pressure Treatment High Cholesterol Treatment Hives Treatment Hypertension Treatment
Hypoglycemia Treatment IBS Treatment Impotence Treatment Indigestion Treatment
Infertility Treatment Influenza Treatment Insomnia Treatment Lactose Intolerance Treatment
Leukemia Treatment Lung Cancer Treatment Lyme Disease Treatment Macular Degeneration Treatment
Menopause Treatment Migraine Treatment Osteoarthritis Treatment Osteoporosis Treatment
Pancreatic Cancer Treatment PMS Treatment Pneumonia Treatment Prostate Diseases Treatment
Restless Leg Treatment Rheumatoid Arthritis Treatment Sepsis Treatment Sinusitis Treatment
Skin Cancer Treatment Sleep Apnea Treatment Snoring Treatment Stroke Treatment
Testicular Cancer Treatment
GoldBambooTM

Your Integrative Health and Wellness Resource for Ileostomy, Colostomy, and Ileoanal Reservoir Surgery.

October 6, 2008


Page Updated: September 6, 2005
Disclaimer: All material displayed on the GoldBamboo.com website is provided for educational purposes only. Consult a physician regarding the applicability of any information found on GoldBamboo.com to your symptoms or medical condition.

Massachusetts Law | Home | About Us | Link To Us | Feedback | Disclaimer | Privacy Policy | Terms of Use | Google Co-op | Health Forums

Copyright © 2004-2008 - Gold Bamboo LLC
All rights reserved.

HONcode accreditation seal.

We comply with the HONcode standard for health trust worthy information:
verify here.