RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Androgens can stimulate the growth of prostate cancer cells. Hormone therapy using flutamide, goserelin, and leuprolide may fight prostate cancer by reducing the production of androgens. It is not yet known which regimen of antiandrogen therapy is most effective for prostate cancer. PURPOSE: Randomized phase III trial to study the effectiveness of radiation therapy with or without antiandrogen therapy in treating patients who have stage I or stage II prostate cancer.

Condition	Treatment or Intervention	Phase
stage II prostate cancer stage I prostate cancer adenocarcinoma of the prostate	Drug: flutamide  Drug: goserelin  Drug: leuprolide	Phase III

Further Study Details: 

OBJECTIVES: I. Compare the overall and disease-specific survival and local and/or distant clinical relapse rate in patients with locally confined carcinoma of the prostate treated with goserelin plus flutamide used as cytoreductive agents prior to definitive radiotherapy vs radiotherapy alone. II. Compare these regimens in terms of freedom from PSA failure, second clinical relapse, and second PSA relapse in these patients. III. Compare prostate rebiopsy results in these patients at 2 years. IV. Determine the effect of goserelin and flutamide therapy on sexual function in these patients.

PROTOCOL OUTLINE: This is a randomized, multicenter study. Patients are stratified by PSA level (less than 4 vs 4-20), tumor differentiation (good vs moderate vs poor), nodal status (N0 vs Nx), and participating center. Patients are randomized to one of two treatment arms. Arm I: Patients receive oral flutamide 3 times a day and goserelin subcutaneously once every 4 weeks, or once as a time release injection (intramuscular leuprolide may be substituted for goserelin), beginning 2 months prior to radiotherapy and continuing until completion of radiotherapy. Patients undergo radiotherapy daily 4-5 days per week for almost 8 weeks. Arm II: Patients undergo radiotherapy only, as in arm I. Patients are followed every 3 months for the remainder of the first year, every 4 months for 1 year, every 6 months for 3 years and then annually thereafter.

PROJECTED ACCRUAL: A total of 1980 patients will be accrued for this study within 5 years.

Criteria

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics--

• Histologically confirmed adenocarcinoma of the prostate
• Clinical stage T1b/1c/2a/2b, Nx or N0, M0 disease (stage I or II); Nodes considered negative by imaging methods classified as Nx; those considered negative by surgical sampling classified as N0

PSA no greater than 20

--Prior/Concurrent Therapy--

• Biologic therapy: Not specified
• Chemotherapy: No prior chemotherapy
• Endocrine therapy: At least 60 days since prior finasteride for prostate hypertrophy; At least 90 days since prior testosterone; No other prior hormonal therapy
• Radiotherapy: No prior radiotherapy
• Surgery: No prior radical surgery or cryosurgery for carcinoma of the prostate

--Patient Characteristics--

• Age: Any age
• Performance status: Karnofsky 70-100%
• Hematopoietic: Not specified
• Hepatic: ALT no greater than 2 times upper limit of normal
• Renal: Not specified
• Other: No major medical or psychiatric illness that would prevent compliance; No other malignancy in the past 5 years except basal or squamous cell skin carcinoma (a minimum of 2 years since squamous cell carcinoma)

Alabama
      Alabama Oncology, LLC, Montgomery,  Alabama,  36106-2801,  United States
      Comprehensive Cancer Institute of Huntsville, Huntsville,  Alabama,  35801,  United States
      Huntsville Hospital System, Huntsville,  Alabama,  35801-4470,  United States
      MBCCOP - Gulf Coast, Mobile,  Alabama,  36688,  United States
      Radiation Oncology Associates of West Alabama, Tuscallosa,  Alabama,  35401,  United States
      University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham,  Alabama,  35294-3300,  United States
Alaska
      Providence Alaska Medical Center, Anchorage,  Alaska,  99508,  United States
Arizona
      Arizona Cancer Center, Tucson,  Arizona,  85724,  United States
California
      California Cancer Center, Fresno,  California,  93720,  United States
      Cancer Care Center, Pomona,  California,  91767,  United States
      Cancer Center and Beckman Research Institute, City of Hope, Duarte,  California,  91010-3000,  United States
      CCOP - Bay Area Tumor Institute, Oakland,  California,  94609-3305,  United States
      CCOP - Santa Rosa Memorial Hospital, Santa Rosa,  California,  95403,  United States
      Glendale Memorial Hospital and Health Center, Glendale,  California,  91204,  United States
      Jonsson Comprehensive Cancer Center, UCLA, Los Angeles,  California,  90095-1781,  United States
      Loma Linda University Medical Center, Loma Linda,  California,  92354,  United States
      Mount Diablo Medical Center, Concord,  California,  94524-4110,  United States
      O'Connor Hospital, San Jose,  California,  95128,  United States
      Radiation Medical Group, Inc., San Diego,  California,  92101-1492,  United States
      Radiation Oncology Center - Sacramento, Sacramento,  California,  95816,  United States
      Saint Agnes Cancer Center, Fresno,  California,  93720,  United States
      Sutter Health Western Division Cancer Research Group, Greenbrae,  California,  94904,  United States
      UCSF Cancer Center and Cancer Research Institute, San Francisco,  California,  94143-0128,  United States
      University of California San Diego Cancer Center, La Jolla,  California,  92093-0658,  United States
      USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles,  California,  90033-0804,  United States
      Veterans Affairs Medical Center - Long Beach, Long Beach,  California,  90822,  United States
Colorado
      Memorial Hospital Cancer Center, Colorado Springs,  Colorado,  80909,  United States
      University of Colorado Cancer Center, Denver,  Colorado,  80010,  United States
Delaware
      CCOP - Christiana Care Health Services, Wilmington,  Delaware,  19899,  United States
District of Columbia
      Walter Reed Army Medical Center, Washington,  District of Columbia,  20307-5000,  United States
Florida
      Baptist Hospital of Miami, Miami,  Florida,  33176-2197,  United States
      Bay Medical Center, Panama City,  Florida,  32401,  United States
      CCOP - Mount Sinai Medical Center, Miami Beach,  Florida,  33140,  United States
      Florida Radiation Oncology Group, Orange Park,  Florida,  32073,  United States
      Gulf Coast Cancer Treatment Center, Panama City,  Florida,  32405-4587,  United States
      H. Lee Moffitt Cancer Center and Research Institute, Tampa,  Florida,  33612-9497,  United States
      Halifax Medical Center, Daytona Beach,  Florida,  32114,  United States
      Health First Holmes Regional Medical Center, Melbourne,  Florida,  32901,  United States
      Lykes Center for Radiation Therapy, Clearwater,  Florida,  33757-0210,  United States
      MD Anderson Cancer Center Orlando, Orlando,  Florida,  32806,  United States
      Radiation Therapy Associates - Fort Myers, Fort Myers,  Florida,  33901,  United States
      Sarasota Radiation and Medical Oncology Center, Sarasota,  Florida,  34233,  United States
      Sylvester Cancer Center, University of Miami, Miami,  Florida,  33136,  United States
      Tallahassee Memorial Healthcare, Tallahassee,  Florida,  32308,  United States
      University of Florida Health Science Center, Gainesville,  Florida,  32610-0296,  United States
      dVeterans Affairs Medical Center - Miami, Miami,  Florida,  33125,  United States
Georgia
      CCOP - Atlanta Regional, Atlanta,  Georgia,  30342-1701,  United States
      Emory University Hospital - Atlanta, Atlanta,  Georgia,  30322,  United States
      InterCommunity Cancer Center at Rome, Rome,  Georgia,  30161,  United States
      Medical Center/John B. Amos Community Cancer Center, Columbus,  Georgia,  31902,  United States
Illinois
      CCOP - Central Illinois, Decatur,  Illinois,  62526,  United States
      Ingalls Memorial Hospital, Harvey,  Illinois,  60426,  United States
      Loyola University Medical Center, Maywood,  Illinois,  60153,  United States
      Lutheran General Cancer Care Center, Park Ridge,  Illinois,  60068,  United States
      Methodist Medical Center of Illinois, Peoria,  Illinois,  61636,  United States
      Northwest Community Hospital, Arlington Heights,  Illinois,  60005,  United States
      Northwestern Memorial Hospital, Chicago,  Illinois,  60611,  United States
      Provena St. Joseph Hospital- Regional Cancer Care Center, Elgin,  Illinois,  60123,  United States
      University of Chicago Cancer Research Center, Chicago,  Illinois,  60637-1470,  United States
Indiana
      Ball Memorial Hospital, Muncie,  Indiana,  47303-3499,  United States
      Clarion Health Partners Inc., Indianapolis,  Indiana,  46206-1367,  United States
      Community Hospitals of Indianapolis - Regional Cancer Center, Indianapolis,  Indiana,  46219,  United States
      St. John's Medical Center, Anderson,  Indiana,  46016,  United States
      Veterans Affairs Medical Center - Indianapolis (Roudebush), Indianapolis,  Indiana,  46202,  United States
Iowa
      Holden Comprehensive Cancer Center at The University of Iowa, Iowa City,  Iowa,  52242-1009,  United States
      Wendt Regional Cancer Center of Finley Hospital, Dubuque,  Iowa,  52001,  United States
Kentucky
      Albert B. Chandler Medical Center, University of Kentucky, Lexington,  Kentucky,  40536-0084,  United States
      James Graham Brown Cancer Center, Louisville,  Kentucky,  40202,  United States
      Louisville Radiation Oncology, Louisville,  Kentucky,  40215,  United States
      Merle M. Mahr Cancer Center, Madisonville,  Kentucky,  42431,  United States
      Veterans Affairs Medical Center - Lexington, Lexington,  Kentucky,  40511-1093,  United States
Louisiana
      CCOP - Ochsner, New Orleans,  Louisiana,  70121,  United States
      Mary Bird Perkins Cancer Center, Baton Rouge,  Louisiana,  70809,  United States
      MBCCOP - LSU Health Sciences Center, New Orleans,  Louisiana,  70112,  United States
      Romagosa Radiation Oncology Center, Lafayette,  Louisiana,  70501,  United States
      Tulane University School of Medicine, New Orleans,  Louisiana,  70112,  United States
Maine
      Maine Medical Center, Portland,  Maine,  04102,  United States
Maryland
      Anne Arundel Oncology Center, Annapolis,  Maryland,  21401,  United States
      Greater Baltimore Medical Center and Cancer Center, Baltimore,  Maryland,  21204,  United States
      Harbor Hospital Center, Baltimore,  Maryland,  21225,  United States
      Johns Hopkins Oncology Center, Baltimore,  Maryland,  21231-2410,  United States
      Peninsula Regional Medical Center, Salisbury,  Maryland,  21801,  United States
      Radiation Oncology Affiliates of Maryland, P.A., Baltimore,  Maryland,  21237,  United States
      Sinai Hospital of Baltimore, Baltimore,  Maryland,  21225,  United States
Massachusetts
      Cape Cod Hospital, Hyannis,  Massachusetts,  02601,  United States
      Veterans Affairs Medical Center - Boston (Jamaica Plain), Jamaica Plain,  Massachusetts,  02130,  United States
Michigan
      Barbara Ann Karmanos Cancer Institute, Detroit,  Michigan,  48201-1379,  United States
      CCOP - Ann Arbor Regional, Ann Arbor,  Michigan,  48106,  United States
      CCOP - Kalamazoo, Kalamazoo,  Michigan,  49007-3731,  United States
      Henry Ford Hospital, Detroit,  Michigan,  48202,  United States
      Hurley Medical Center, Flint,  Michigan,  48503,  United States
      Marquette General Hospital, Marquette,  Michigan,  49855,  United States
      McLaren Regional Cancer Center, Flint,  Michigan,  48432,  United States
      MidMichigan Medical Center - Midland, Midland,  Michigan,  48670,  United States
      St. Mary's Medical Center, Saginaw,  Michigan,  48601,  United States
      University of Michigan Comprehensive Cancer Center, Ann Arbor,  Michigan,  48109-0752,  United States
      William Beaumont Hospital, Royal Oak,  Michigan,  48073,  United States
Minnesota
      CCOP - Metro-Minnesota, Saint Louis Park,  Minnesota,  55416,  United States
      Mayo Clinic Cancer Center, Rochester,  Minnesota,  55905,  United States
Mississippi
      North Mississippi Medical Center/Cancer Center, Tupelo,  Mississippi,  38801,  United States
Missouri
      Cancer Research for the Ozarks, Springfield,  Missouri,  65807,  United States
      CCOP - Cancer Research for the Ozarks, Springfield,  Missouri,  65807,  United States
      CCOP - Kansas City, Kansas City,  Missouri,  64131,  United States
      Ellis Fischel Cancer Center - Columbia, Columbia,  Missouri,  65203,  United States
      Mallinckrodt Institute of Radiology, Saint Louis,  Missouri,  63110,  United States
      St. Louis University Health Sciences Center, Saint Louis,  Missouri,  63110-0250,  United States
Montana
      CCOP - Montana Cancer Consortium, Billings,  Montana,  59101,  United States
Nebraska
      Methodist Cancer Center - Omaha, Omaha,  Nebraska,  68114,  United States
      Nebraska Health System, Omaha,  Nebraska,  68105-1018,  United States
Nevada
      CCOP - Southern Nevada Cancer Research Foundation, Las Vegas,  Nevada,  89106,  United States
New Hampshire
      Elliot Regional Cancer Center, Manchester,  New Hampshire,  03103,  United States
      Norris Cotton Cancer Center, Lebanon,  New Hampshire,  03756-0002,  United States
New Jersey
      Associated Radiologists, P.A., Warren,  New Jersey,  07059,  United States
      Atlantic City Medical Center, Pomona,  New Jersey,  08240,  United States
      Cancer Institute of New Jersey, New Brunswick,  New Jersey,  08901,  United States
      Capital Health System at Mercer, Trenton,  New Jersey,  08607,  United States
      Community Medical Center, Toms River,  New Jersey,  08755,  United States
      Cooper Cancer Institute, Camden,  New Jersey,  08103,  United States
      Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County, Mount Holly,  New Jersey,  08060,  United States
      John F. Kennedy Medical Center, Edison,  New Jersey,  08818,  United States
      Monmouth Medical Center, Long Branch,  New Jersey,  07740-6395,  United States
      Newark Beth Israel Medical Center, Newark,  New Jersey,  07112,  United States
      South Jersey Regional Cancer Center, Millville,  New Jersey,  08332,  United States
      St. Francis Medical Center, Trenton,  New Jersey,  08629,  United States
      Trinitas Hospital - Jersey Street Campus, Elizabeth,  New Jersey,  07201,  United States
      Veterans Affairs Medical Center - East Orange, East Orange,  New Jersey,  07018-1095,  United States
New Mexico
      Saint Joseph Medical Center, Albuquerque,  New Mexico,  87102,  United States
New York
      Albert Einstein Comprehensive Cancer Center, Bronx,  New York,  10461,  United States
      Beth Israel Medical Center, New York,  New York,  10003,  United States
      Cancer Center of Albany Medical Center, Albany,  New York,  12208,  United States
      CCOP - North Shore University Hospital, Manhasset,  New York,  11030,  United States
      Champlain Valley Physicians Hospital Medical Center, Plattsburgh,  New York,  12901,  United States
      Finger Lakes Radiation Oncology, P.C., Clifton Springs,  New York,  14432,  United States
      Herbert Irving Comprehensive Cancer Center, New York,  New York,  10032,  United States
      Memorial Sloan-Kettering Cancer Center, New York,  New York,  10021,  United States
      New York Medical College, Valhalla,  New York,  10595,  United States
      New York Methodist Hospital, Brooklyn,  New York,  11215-3609,  United States
      Roswell Park Cancer Institute, Buffalo,  New York,  14263-0001,  United States
      State University of New York Health Science Center at Brooklyn, Brooklyn,  New York,  11203,  United States
      University of Rochester Cancer Center, Rochester,  New York,  14642,  United States
      Vassar Brothers Hospital, Poughkeepsie,  New York,  12601,  United States
North Carolina
      Catawba Memorial Hospital, Hickory,  North Carolina,  28601,  United States
      CCOP - Southeast Cancer Control Consortium, Winston Salem,  North Carolina,  27104-4241,  United States
      Comprehensive Cancer Center at Wake Forest University, Winston Salem,  North Carolina,  27157-1082,  United States
      East Carolina University School of Medicine, Greenville,  North Carolina,  27858-4354,  United States
      Lineberger Comprehensive Cancer Center, UNC, Chapel Hill,  North Carolina,  27599-7295,  United States
      Northeast Medical Center, Concord,  North Carolina,  28025,  United States
North Dakota
      Meritcare Roger Maris Cancer Center, Fargo,  North Dakota,  58122,  United States
Ohio
      Akron City Hospital, Akron,  Ohio,  44309,  United States
      Akron General Medical Center, Akron,  Ohio,  44302,  United States
      Arthur G. James Cancer Hospital - Ohio State University, Columbus,  Ohio,  43210-1240,  United States
      CCOP - Columbus, Columbus,  Ohio,  43206,  United States
      CCOP - Dayton, Kettering,  Ohio,  45429,  United States
      CCOP - Toledo Community Hospital Oncology Program, Toledo,  Ohio,  43623-3456,  United States
      Christ Hospital, Cincinnati,  Ohio,  45219,  United States
      Ireland Cancer Center, Cleveland,  Ohio,  44106-5065,  United States
      University Hospitals of Cleveland, Cleveland,  Ohio,  44106,  United States
Oklahoma
      St. Anthony Hospital, Oklahoma City,  Oklahoma,  73101,  United States
      St. John Health System, Tulsa,  Oklahoma,  74104,  United States
Oregon
      CCOP - Columbia River Program, Portland,  Oregon,  97213,  United States
Pennsylvania
      Albert Einstein Cancer Center, Philadelphia,  Pennsylvania,  19141,  United States
      CCOP - MainLine Health, Wynnewood,  Pennsylvania,  19096,  United States
      Delaware County Memorial Hospital, Drexel Hill,  Pennsylvania,  19026,  United States
      Fox Chase Cancer Center, Philadelphia,  Pennsylvania,  19111,  United States
      Geisinger Medical Center, Danville,  Pennsylvania,  17822-2001,  United States
      Hahnemann University Hospital, Philadelphia,  Pennsylvania,  19102-1192,  United States
      Kimmel Cancer Center of Thomas Jefferson University - Philadelphia, Philadelphia,  Pennsylvania,  19107-5541,  United States
      Lehigh Valley Hospital, Allentown,  Pennsylvania,  18103,  United States
      Mercy Catholic Medical Center, Mercy Fitzgerald Divison, Darby,  Pennsylvania,  19023,  United States
      Mercy Hospital Cancer Center - Scranton, Scranton,  Pennsylvania,  18501,  United States
      Mercy Hospital of Pittsburgh, Pittsburgh,  Pennsylvania,  15219,  United States
      Penn State Geisinger Cancer Center, Hershey,  Pennsylvania,  17033,  United States
      Reading Hospital and Medical Center, Reading,  Pennsylvania,  19612-6052,  United States
      St. Luke's Hospital Regional Cancer Center, Bethlehem,  Pennsylvania,  18015,  United States
      University of Pennsylvania Cancer Center, Philadelphia,  Pennsylvania,  19104-4283,  United States
      University of Pittsburgh Cancer Institute, Pittsburgh,  Pennsylvania,  15213-3489,  United States
      Veterans Affairs Medical Center - Philadelphia, Philadelphia,  Pennsylvania,  19104,  United States
      Western Pennsylvania Hospital, Pittsburgh,  Pennsylvania,  15224,  United States
      Wilkes Barre General Hospital, Wilkes Barre,  Pennsylvania,  18764,  United States
      York Hospital, York,  Pennsylvania,  17315,  United States
Rhode Island
      Roger Williams Medical Center/BUSM, Providence,  Rhode Island,  02908-4735,  United States
South Carolina
      CCOP - Greenville, Greenville,  South Carolina,  29615,  United States
      CCOP - Upstate Carolina, Spartanburg,  South Carolina,  29303,  United States
      Medical University of South Carolina, Charleston,  South Carolina,  29425-0721,  United States
South Dakota
      Rapid City Regional Hospital, Rapid City,  South Dakota,  57709,  United States
Tennessee
      Jackson-Madison County General Hospital, Jackson,  Tennessee,  38301,  United States
      University of Tennessee, Memphis Cancer Center, Memphis,  Tennessee,  38103,  United States
      Vanderbilt-Ingram Cancer Center, Nashville,  Tennessee,  37232-6838,  United States
Texas
      Bayshore Medical Center, Pasadena,  Texas,  77504,  United States
      East Texas Medical Center - Cancer Institute, Tyler,  Texas,  75701,  United States
      Harrington Cancer Center, Amarillo,  Texas,  79106,  United States
      Joe Arrington Cancer Research and Treatment Center, Lubbock,  Texas,  79410-1894,  United States
      Julie and Ben Rogers Cancer Institute, Beaumont,  Texas,  77701,  United States
      University of Texas - MD Anderson Cancer Center, Houston,  Texas,  77030-4009,  United States
      University of Texas Medical Branch, Galveston,  Texas,  77555-0209,  United States
      Wilford Hall - 59th Medical Wing, Lackland Air Force Base,  Texas,  78236-5300,  United States
Utah
      Dixie Regional Medical Center, Saint George,  Utah,  84770,  United States
      LDS Hospital, Salt Lake City,  Utah,  84143,  United States
      University of Utah Health Sciences Center, Salt Lake City,  Utah,  84132,  United States
Vermont
      CCOP - Southwestern Vermont Regional Cancer Center, Bennington,  Vermont,  05201,  United States
      Green Mountain Oncology Group, Rutland,  Vermont,  05701,  United States
      Vermont Cancer Center, Burlington,  Vermont,  05401-3498,  United States
Virginia
      Cancer Center at the University of Virginia, Charlottesville,  Virginia,  22908,  United States
      Martha Jefferson Hospital, Charlottesville,  Virginia,  22901,  United States
      RMH Regional Canter Center, Harrisonburg,  Virginia,  22801,  United States
Washington
      Deaconess Medical Center, Spokane,  Washington,  99210-0248,  United States
      Virginia Mason Medical Center, Seattle,  Washington,  98111,  United States
      Yakima Valley Memorial Hospital, Yakima,  Washington,  98902,  United States
West Virginia
      Schiffler Cancer Center, Wheeling,  West Virginia,  26003,  United States
Wisconsin
      Columbia Hospital, Milwaukee,  Wisconsin,  53211,  United States
      Community Memorial Hospital, Menomonee Falls,  Wisconsin,  53051,  United States
      Gundersen Lutheran Medical Foundation, La Crosse,  Wisconsin,  54601,  United States
      Marshfield Clinic, Marshfield,  Wisconsin,  54449,  United States
      Medical College of Wisconsin, Milwaukee,  Wisconsin,  53226,  United States
      Southeastern Wisconsin Regional Cancer Center, Racine,  Wisconsin,  53405,  United States
      Southern Wisconsin Radiotherapy Center, Madison,  Wisconsin,  53713,  United States
      St. Joseph's Hospital, Milwaukee,  Wisconsin,  53210,  United States
      St. Luke's Medical Center, Milwaukee,  Wisconsin,  53215,  United States
      St. Vincent Hospital, Green Bay,  Wisconsin,  54307-3508,  United States
      University of Wisconsin Comprehensive Cancer Center, Madison,  Wisconsin,  53792-6164,  United States
      Veterans Affairs Medical Center - Milwaukee (Zablocki), Milwaukee,  Wisconsin,  53295,  United States
      Waukesha Memorial Hospital, Waukesha,  Wisconsin,  53188,  United States
Canada, Alberta
      Cross Cancer Institute, Edmonton,  Alberta,  T6G 1Z2,  Canada
      Tom Baker Cancer Center - Calgary, Calgary,  Alberta,  T2N 4N2,  Canada
Canada, British Columbia
      British Columbia Cancer Agency, Vancouver,  British Columbia,  V5Z 4E6,  Canada
Canada, New Brunswick
      Saint John Regional Hospital, Saint John,  New Brunswick,  E2L 4L2,  Canada
Canada, Newfoundland and Labrador
      Newfoundland Cancer Treatment and Research Foundation, St. Johns,  Newfoundland and Labrador,  A1B 3V6,  Canada
Canada, Nova Scotia
      Nova Scotia Cancer Centre, Halifax,  Nova Scotia,  B3H 1V7,  Canada
Canada, Ontario
      Cancer Care Ontario-Hamilton Regional Cancer Centre, Hamilton,  Ontario,  L8V 5C2,  Canada
      Cancer Care Ontario-London Regional Cancer Centre, London,  Ontario,  N6A 4L6,  Canada
      Kingston Regional Cancer Centre, Kingston,  Ontario,  K7L 5P9,  Canada
      Northeastern Ontario Regional Cancer Centre, Sudbury, Sudbury,  Ontario,  P3E 5J1,  Canada
      Northwestern Ontario Regional Cancer Centre, Thunder Bay, Thunder Bay,  Ontario,  P7A 7T1,  Canada
      Ottawa Regional Cancer Centre - General Campus, Ottawa,  Ontario,  K1H 1C4,  Canada
      Princess Margaret Hospital, Toronto,  Ontario,  M5G 2M9,  Canada
      Toronto Sunnybrook Regional Cancer Centre, Toronto,  Ontario,  M4N 3M5,  Canada
Canada, Quebec
      CHUS-Hopital Fleurimont, Fleurimont,  Quebec,  J1H 5N4,  Canada
      McGill University, Montreal,  Quebec,  H2W 1S6,  Canada
Canada, Saskatchewan
      Saskatoon Cancer Centre, Saskatoon,  Saskatchewan,  S7N 4H4,  Canada

Study chairs or principal investigators

David G. McGowan,  Study Chair,  Radiation Therapy Oncology Group   

Study ID Numbers:  CDR0000063821; RTOG-9408
Record last reviewed:  February 2004
Last Updated:  October 13, 2004
Record first received:  November 1, 1999
ClinicalTrials.gov Identifier:  NCT00002597
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08