OBJECTIVES: I. Determine whether allelic differences associated with the fourth component of complement, type-1 complement receptor expressed on erythrocytes, and Fc receptor FcgRIII contribute to the pathogenesis of IgA glomerulonephritis (IgA-N). II. Compare genetic anomalies of these key components in immune complex processing and clearance between juvenile vs adult onset IgA-N vs normal controls.

Condition
IGA Glomerulonephritis

Further Study Details: 

Expected Total Enrollment:  105

PROTOCOL OUTLINE: Participants undergo qualitative genetic analysis of complement-related proteins. Studies include: genomic re-arrangement of 4-gene unit, C4 DNA sequence and RNA expression, type-1 complement receptor DNA sequence, Fc-gamma receptor IIIA isoform analysis, classical and alternative complement activation pathway assays, plasma C4 and C4d protein levels, and immunoglobulin patterns in glomerular deposits.

Genders Eligible for Study:  Both

Criteria

• IgA glomerulonephritis

Ohio
      Ohio State University, Columbus,  Ohio,  United States

Study chairs or principal investigators

Lee A. Hebert,  Study Chair,  Ohio State University   

Study ID Numbers:  199/11791; OSU-94H0338
Record last reviewed:  April 2002
Last Updated:  October 13, 2004
Record first received:  October 18, 1999
ClinicalTrials.gov Identifier:  NCT00004305
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08