Not Signed In -
Imaging of the Urinary Tract |
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Clinical Trial: Identification of the Cranberry Juice Compounds that Prevent Urinary Tract Infections
This study is no longer recruiting patients.
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Purpose
The purpose of this study is to identify the substances in cranberry juice that make it effective in reducing urinary tract infections (UTIs) in women.
| Condition | Treatment or Intervention |
|---|---|
| Urinary Tract Infections | Drug: Cranberry juice cocktail |
MedlinePlus related topics: Urinary Tract Infections
Study Type: Interventional
Study Design: Diagnostic, Non-Randomized, Open Label, Historical Control, Single Group Assignment, Pharmacodynamics Study
Official Title: Cranberry Juice Metabolites in Urine
Expected Total Enrollment: 5
Study start: November 2000
Urinary tract infections (UTIs) are a significant health issue, with one fourth of all women experiencing symptoms during their lifetimes. Cranberry juice has been shown to reduce the incidence of UTIs by preventing bacteria from adhering to the bladder. However, the compounds that direct this activity have not been identified. This study will identify and examine UTI-reducing compounds in cranberry juice.
Participants in this study will drink a specified amount of water following an overnight fast. Their urine will be collected 1 to 3 hours after the water is consumed. Several days later, the women will be provided with cranberry juice to replace the water in the regimen. Urine samples will be analyzed for compounds that have antibacterial or antiadhesion activity against the bacteria that cause UTIs.
Eligibility
Ages Eligible for Study: 18 Years - 64 Years, Genders Eligible for Study: Female
Accepts Healthy Volunteers
Criteria
Inclusion Criteria:
- Good overall health
Exclusion Criteria:
- History of urinary tract infections
- Use of cranberry products or antibiotics within 1 week of study start
- Current use of any other medication
- Hypertension
- Diabetes
- Pregnancy
Location Information
Illinois
Dept Medicinal Chemistry & Pharmacognosy, COP, UIC, Chicago, Illinois, 60612, United States
More Information
Publications
Ahuja S, Kaack B, Roberts J. Loss of fimbrial adhesion with the addition of Vaccinum macrocarpon to the growth medium of P-fimbriated Escherichia coli. J Urol. 1998 Feb;159(2):559-62.
Avorn J, Monane M, Gurwitz JH, Glynn RJ, Choodnovskiy I, Lipsitz LA. Reduction of bacteriuria and pyuria after ingestion of cranberry juice. JAMA. 1994 Mar 9;271(10):751-4.
Foo LY, Lu Y, Howell AB, Vorsa N. A-Type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli. J Nat Prod. 2000 Sep;63(9):1225-8.
Foo LY, Lu Y, Howell AB, Vorsa N. The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro. Phytochemistry. 2000 May;54(2):173-81.
Schmidt DR, Sobota AE. An examination of the anti-adherence activity of cranberry juice on urinary and nonurinary bacterial isolates. Microbios. 1988;55(224-225):173-81.
Record last reviewed: September 2004
Last Updated: October 13, 2004
Record first received: July 14, 2004
ClinicalTrials.gov Identifier: NCT00087828
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 9, 2005
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