Alpha-1 Antitrypsin Clinical Trials

• 4-PBA: Will it increase the level of Alpha 1-Antitrypsin(AAT) in persons with AAT deficiency?
  ClinicalTrials.gov Identifier: NCT00067756 - Active, not recruiting
  alpha 1-Antitrypsin Deficiency
  
• Study of the Effect of Aerosolized, Recombinant Alpha 1-Antitrypsin on Epithelial Lining Fluid Analytes in Subjects With Alpha 1-Antitrypsin Deficiency
  ClinicalTrials.gov Identifier: NCT00157092 - Completed
  alpha 1-Antitrypsin Deficiency
  
• Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency
  ClinicalTrials.gov Identifier: NCT00377416 - Active, not recruiting
  Alpha 1-Antitrypsin Deficiency
  
• Safety Study of an Aerosolized, Recombinant Alpha 1-Antitrypsin in Subjects with Alpha 1-Antitrypsin Deficiency
  ClinicalTrials.gov Identifier: NCT00161707 - Completed
  alpha 1-Antitrypsin Deficiency
  
• Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency
  ClinicalTrials.gov Identifier: NCT00430768 - Recruiting
  Alpha 1-Antitrypsin Deficiency
  
• The Use of High Resolution Chest Computed Tomography in Alpha-1 Antitrypsin Deficiency
  ClinicalTrials.gov Identifier: NCT00532805 - Recruiting
  Alpha-1 Antitrypsin Deficiency
  
• Phase II/III Study of an Alpha-1 Proteinase Inhibitor (Kamada-API) in Individuals With Alpha-1 Antitrypsin Deficiency
  ClinicalTrials.gov Identifier: NCT00460096 - Completed
  Alpha 1-Antitrypsin Deficiency
  
• The Comparison of the Pharmacokinetic, Safety and Tolerability of Alpha-1 MP and Prolastin in Adult alpha1-Antitrypsin Deficient Patients.
  ClinicalTrials.gov Identifier: NCT00295061 - Completed
  Alpha 1-Antitrypsin Deficiency
  
• The Safety and Tolerability of Alpha-1 MP in Subjects With Alpha-1-Antitrypsin (AAT) Deficiency.
  ClinicalTrials.gov Identifier: NCT00301366 - Completed
  Alpha 1-Antitrypsin Deficiency
  
• Alpha-1 Coded Testing Study (ACT Trial)
  ClinicalTrials.gov Identifier: NCT00500123 - Recruiting
  Alpha 1-Antitrypsin Deficiency
  
• Alpha-1 Foundation Research Registry
  ClinicalTrials.gov Identifier: NCT00499941 - Recruiting
  Alpha 1-Antitrypsin Deficiency
  
• Efficacy and Safety Study of Augmentation Therapy With Aralast (Human Alpha 1 - Proteinase Inhibitor)
  ClinicalTrials.gov Identifier: NCT00396006 - Recruiting
  Alpha 1-Antitrypsin Deficiency
  
• Characterization of the Pathobiology of Early Lung Destruction in Alpha 1-Antitrypsin Deficient Individuals
  ClinicalTrials.gov Identifier: NCT00001462 - Completed
  Emphysema; Lung Diseases, Obstructive; alpha 1-Antitrypsin Deficiency
  
• Study of Genotype and Phenotype in Patients With Alpha 1-Antitrypsin Deficiency
  ClinicalTrials.gov Identifier: NCT00005098 - Terminated
  alpha 1-Antitrypsin Deficiency
  
• Aralast alpha1-Proteinase Inhibitor Surveillance Study
  ClinicalTrials.gov Identifier: NCT00313144 - Active, not recruiting
  Alpha 1-Antitrypsin Deficiency
  
• Pharmacokinetic Study of Aralast (Human Alpha1- PI)
  ClinicalTrials.gov Identifier: NCT00242385 - Completed
  Alpha 1-Antitrypsin Deficiency
  
• Antitrypsin (AAT) To Treat Emphysema In AAT-Deficient Patients
  ClinicalTrials.gov Identifier: NCT00263887 - Completed
  Alpha 1-Antitrypsin Deficiency
  
• Alpha1-antitrypsin Deficiency Registry
  ClinicalTrials.gov Identifier: NCT00005292 - Completed
  Lung Diseases; Emphysema; Alpha-1 antitrypsin deficiency; Chronic Obstructive Pulmonary Disease
  
• Evaluating the Genetic Causes and Progression of Cholestatic Liver Diseases
  ClinicalTrials.gov Identifier: NCT00571272 - Recruiting
  Liver Diseases; Alagille Syndrome; Alpha 1-Antitrypsin Deficiency
  
• Phase II Study of the Safety and Efficacy of Inhaled Alpha-1 Antitrypsin (AAT ) in Cystic Fibrosis Patients
  ClinicalTrials.gov Identifier: NCT00499837 - Recruiting
  Cystic Fibrosis
  
• Genetics of Alpha Thalassemia in Israeli Ethnic Groups
  ClinicalTrials.gov Identifier: NCT00159029 - Recruiting
  alpha Thalassemia
  
• Standard High-Dose Alpha Interferon Versus Intermittent High-Dose Alpha Interferon
  ClinicalTrials.gov Identifier: NCT00226408 - Recruiting
  Adjuvant; Stage III Malignant Melanoma; Interferon Alpha; Therapy
  
• ABR-217620 With Interferon-Alpha (IFN-Alpha) Compared to IFN-Alpha Alone in Patients With Advanced Renal Cell Carcinoma
  ClinicalTrials.gov Identifier: NCT00420888 - Recruiting
  Renal Cell Carcinoma
  
• The Natural History of Alpha-Mannosidosis
  ClinicalTrials.gov Identifier: NCT00498420 - Recruiting
  Alpha Mannosidosis
  
• Provision of Antioxidant Therapy in Hemodialysis (PATH) Study
  ClinicalTrials.gov Identifier: NCT00237718 - Recruiting
  End Stage Renal Disease
  
• Ingested Interferon Alpha: Prolongation or Permanence of the "Honeymoon" Phase in Newly Diagnosed Type 1 Diabetes Mellitus
  ClinicalTrials.gov Identifier: NCT00005665 - Active, not recruiting
  Diabetes Mellitus, Type 1
  
• Interferon-Alpha for Diabetes Mellitus Type 1
  ClinicalTrials.gov Identifier: NCT00024518 - Active, not recruiting
  Insulin-Dependent Diabetes Mellitus
  
• Therapy of Early Chronic Phase Chronic Myelogenous Leukemia with Gleevec, Alpha Interferon, and Ara-C
  ClinicalTrials.gov Identifier: NCT00048672 - Active, not recruiting
  Leukemia, Myeloid, Chronic-Phase
  
• Efficacy of Prazosin Versus Placebo Associated with Peg-Interferon Alpha 2b and Ribavirin in Chronic Hepatitis C with Genotype 1 or 4 and Severe Fibrosis
  ClinicalTrials.gov Identifier: NCT00148837 - Active, not recruiting
  Hepatitis C, Chronic; Fibrosis
  
• Painful HIV Neuropathy and Alpha-Lipoic Acid
  ClinicalTrials.gov Identifier: NCT00079807 - Active, not recruiting
  HIV; Peripheral Neuropathy
  
• Therapy of Early Chronic Phase Chronic Myelogenous Leukemia (CML) with Higher-Dose Gleevec, Alpha Interferon, and Low-Dose Ara-C
  ClinicalTrials.gov Identifier: NCT00038649 - Active, not recruiting
  Myelogenous Leukemia, Chronic, Chronic Phase
  
• Long-term Peginterferon alpha-2a Plus Ribavirin to Treat Chronic Hepatitis C in HIV-Infected Patients
  ClinicalTrials.gov Identifier: NCT00076765 - Recruiting
  Hepatitis C; HIV Infections
  
• Beta-Carotene and Alpha-Tocopherol Chemoprevention of Second Primary Malignancies in Head and Neck Cancer Patients
  ClinicalTrials.gov Identifier: NCT00169845 - Active, not recruiting
  Neoplasms
  
• Peginterferon alpha-2b And Ribavirin to Treat Hepatitis C in HIV-Infected Patients
  ClinicalTrials.gov Identifier: NCT00018031 - Recruiting
  Hepatitis C; HIV Infections
  
• Alberta Physical Activity and Breast Cancer Prevention (ALPHA) Trial
  ClinicalTrials.gov Identifier: NCT00522262 - Active, not recruiting
  Breast Neoplasms
  
• Pegylated Interferon-Alpha-2a in Patients With Malignant Melanoma Stage IIA-IIIB
  ClinicalTrials.gov Identifier: NCT00204529 - Active, not recruiting
  Melanoma
  
• PEG Interferon Alpha 2B and Low-Dose Ara-C in Early Chronic Phase CML
  ClinicalTrials.gov Identifier: NCT00303290 - Active, not recruiting
  Chronic Myeloid Leukemia
  
• The Role of Vitamins E and C in Maintaining Lung Health in People with Asthma
  ClinicalTrials.gov Identifier: NCT00142610 - Active, not recruiting
  Asthma
  
• Low-Dose IL-2 Plus IFN-Alpha Immunotherapy as Adjuvant Treatment of Renal Carcinoma.
  ClinicalTrials.gov Identifier: NCT00502034 - Active, not recruiting
  Carcinoma, Renal Cell
  
• Safety Study of TroVax Alone vs. TroVax Plus Interferon Alpha in Patients With Renal Cancer
  ClinicalTrials.gov Identifier: NCT00445523 - Active, not recruiting
  Carcinoma, Renal Cell
  
• Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study
  ClinicalTrials.gov Identifier: NCT00342992 - Active, not recruiting
  Lung Cancer; Prostatic Neoplasms; Prostate Cancer; Pancreatic Cancer
  
• 48 Weeks Combination Therapy for Patients with HBeAg-negative Chronic Hepatitis B Virus (HBV) Infection
  ClinicalTrials.gov Identifier: NCT00114361 - Active, not recruiting
  Hepatitis B
  
• Study to Evaluate Viral Kinetics in the First 12 Weeks of Patients With Hepatitis C Coinfected With HIV Treated With Induction Doses of Peginterferon Alpha-2a (40 KD) and Ribavirin With Epoetin β Support
  ClinicalTrials.gov Identifier: NCT00356486 - Active, not recruiting
  HIV Infections
  
• The Role of 5-Alpha Reductase in Mediating Testosterone Actions
  ClinicalTrials.gov Identifier: NCT00493987 - Recruiting
  Healthy
  
• Investigating the Role of Norepinephrine in Emotional Processing through Alpha-2 Adrenergic Receptor Modulation
  ClinicalTrials.gov Identifier: NCT00109642 - Recruiting
  
  
• Phase I Study of Alpha-Melanocyte Stimulating Hormone in Patients with Acute Renal Failure
  ClinicalTrials.gov Identifier: NCT00004496 - Recruiting
  Acute Renal Failure
  
• Pilot Study on the Effect of Oral Controlled-Release Alpha-Lipoic Acid on Oxidative Stress in Adolescents With Type 1 Diabetes Mellitus
  ClinicalTrials.gov Identifier: NCT00187564 - Active, not recruiting
  Diabetes Mellitus, Type 1
  
• Alpha Lipoic Acid and Polycystic Ovary Syndrome
  ClinicalTrials.gov Identifier: NCT00505427 - Recruiting
  Insulin Resistance; Oxidative Stress
  
• Total Therapy II
  ClinicalTrials.gov Identifier: NCT00083551 - Active, not recruiting
  Multiple Myeloma
  
• Evaluation of cccDNA and Total HBV DNA Kinetics in Lymphocytes, Total Blood and Serum in Chronic Hepatitis B Patients Treated With Adefovir Dipivoxil and Peg Interferon Alpha 2a
  ClinicalTrials.gov Identifier: NCT00199732 - Active, not recruiting
  Chronic Hepatitis B
  
• Tocopherols and Alpha Lipoic Acid Treatment Chronic Kidney Disease (TALAT)
  ClinicalTrials.gov Identifier: NCT00308971 - Active, not recruiting
  Chronic Kidney Disease
  
• A Study to Collect Normative Data on Fabry Disease Patients with Enhanceable Alpha-Galactosidase a Activity
  ClinicalTrials.gov Identifier: NCT00106912 - Recruiting
  
  
• Prevention of Preterm Delivery in Twin Pregnancies by 17 Alpha-Hydroxyprogesterone Caproate
  ClinicalTrials.gov Identifier: NCT00141908 - Not yet recruiting
  Preterm Delivery
  
• Comparison of the Alpha-2 Agonists for Prevention of Intraocular Pressure Elevation After Selective Laser Trabeculoplasty
  ClinicalTrials.gov Identifier: NCT00567411 - Recruiting
  Glaucoma; Ocular Hypertension
  
• Peginterferon alpha-2a and ribavirin to treat hepatitis C in HIV-infected patients
  ClinicalTrials.gov Identifier: NCT00085917 - Active, not recruiting
  Hepatitis C; HIV Infections
  
• Anti-Oxidant Treatment of Alzheimer''s Disease
  ClinicalTrials.gov Identifier: NCT00117403 - Active, not recruiting
  Alzheimer''s Disease
  
• Glivec® (Imatinib Mesylate, STI571) in Monotherapy Versus Glivec®-Interferon Alpha in the Treatment of Chronic-Phase Chronic Myeloid Leukaemia
  ClinicalTrials.gov Identifier: NCT00390897 - Active, not recruiting
  Chronic Myeloid Leukaemia
  
• Paroxetine for the Treatment of Interferon Related Side Effects for Hepatitis C
  ClinicalTrials.gov Identifier: NCT00209118 - Active, not recruiting
  Hepatitis C; Depression; Interferon-Alpha Associated Side Effects
  
• One-Year Prospective Observational Study of BMI Change Effect of 5-Alpha Reductase Inhibitor in Korean BPH Patients
  ClinicalTrials.gov Identifier: NCT00472251 - Recruiting
  Benign Prostatic Hyperplasia
  
• Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS)
  ClinicalTrials.gov Identifier: NCT00099164 - Active, not recruiting
  Preterm birth; Pregnancy, multiple
  
• Recombinant Interferon Alpha and Etoposide in Relapsed Osteosarcoma
  ClinicalTrials.gov Identifier: NCT00504140 - Recruiting
  Osteosarcoma
  
• A Pilot Trial of Oral Topotecan for the Treatment of Refractory Advanced Solid Neoplasms Expressing HIF-1 Alpha
  ClinicalTrials.gov Identifier: NCT00117013 - Recruiting
  
  
• Cardiovascular and Autonomic Reactivity in Women with a History of Pre-Eclampsia
  ClinicalTrials.gov Identifier: NCT00117546 - Recruiting
  Preeclampsia
  
• Effectiveness and Side Effects of Pegylated Interferon Alpha-2a (Pegaferon®) Plus Ribavirin in the Patients With Chronic Hepatitis C
  ClinicalTrials.gov Identifier: NCT00527540 - Recruiting
  Hepatitis C
  
• Alpha-Lipoic Acid in Preventing Hearing Loss in Cancer Patients Undergoing Treatment With Cisplatin
  ClinicalTrials.gov Identifier: NCT00477607 - Recruiting
  Ototoxicity; Unspecified Adult Solid Tumor, Protocol Specific
  
• Alpha-Lipoic Acid in Preventing Hearing Loss in Cancer Patients Undergoing Treatment With Cisplatin
  ClinicalTrials.gov Identifier: NCT00570596 - Recruiting
  Ototoxicity; Unspecified Adult Solid Tumor, Protocol Specific
  
• Thymosin Plus PEG-Interferon in Hepatitis C Patients with Cirrhosis Who Did Not Respond to Interferon or Interferon Plus Ribavirin
  ClinicalTrials.gov Identifier: NCT00039962 - Active, not recruiting
  Hepatitis C; Hepatitis C, Chronic
  
• Racial Differences in HCV/Host Interactions
  ClinicalTrials.gov Identifier: NCT00071916 - Recruiting
  Hepatitis C
  
• A Study of Debio 025 in Combination With Peginterferon Alpha-2a and Ribavirin in Chronic HCV Patients Non-Responders to Standard Treatment
  ClinicalTrials.gov Identifier: NCT00537407 - Recruiting
  Chronic Hepatitis C
  
• Pegylated Interferon to Treat Chronic Hepatitis D
  ClinicalTrials.gov Identifier: NCT00023322 - Recruiting
  Hepatitis D
  
• Efficacy and Tolerance of Peg-Interferon Alpha 2a Added to Tenofovir and Emtricitabine in AgHBe Positive HBV-HIV co-Infected Patients
  ClinicalTrials.gov Identifier: NCT00391638 - Recruiting
  Hepatitis B; HIV Infections
  
• Prevention of Depression With Omega-3 Fatty Acids in Chronic Carriers of Hepatitis C Treated With Interferon Alpha.
  ClinicalTrials.gov Identifier: NCT00408304 - Recruiting
  Chronic Hepatitis C
  
• The Effectiveness of Saw Palmetto and Sanmiaoshan on Benign Prostatic Hyperplasia in Chinese Patients
  ClinicalTrials.gov Identifier: NCT00497939 - Recruiting
  Prostatic Hyperplasia; Adrenergic Alpha-Antagonists
  
• Low Dose Interferon Alpha Treatment for Oral Ulcers of Behcet's Disease
  ClinicalTrials.gov Identifier: NCT00483184 - Recruiting
  Behcet Syndrome; Behcet Disease; Mucocutaneous Ulceration
  
• Efficacy of 17 Alpha-Hydroxyprogesterones Caproate for the Prevention of Preterm Delivery
  ClinicalTrials.gov Identifier: NCT00331695 - Recruiting
  Preterm Delivery Risk
  
• Retreatment of Chronic Hepatitis C Non-Responders With Pegylated Interferon Alpha + Ribavirin + Pioglitazone
  ClinicalTrials.gov Identifier: NCT00433069 - Recruiting
  Chronic Hepatitis C
  
• Alpha-Cell Sensitivity to GLP-1 in Patients With Type 2 Diabetes
  ClinicalTrials.gov Identifier: NCT00497133 - Recruiting
  Type 2 Diabetes Mellitus
  
• Assessment of an Alpha-Glucosidase Inhibitor to Block Cardiac Events in Patients With Myocardial Infarction and IGT (ABC Study)
  ClinicalTrials.gov Identifier: NCT00212017 - Recruiting
  Impaired Glucose Tolerance; Myocardial Infarction
  
• AFR10 - Combination Therapy of Imatinib Mesylate (IM) + Alpha-2A Interferon for Chronic Phase CML Patients Resistant or Refractory to IM Used as Single Therapy for at Least One Year
  ClinicalTrials.gov Identifier: NCT00146913 - Active, not recruiting
  Chronic Myeloid Leukemia
  
• Thymosin Plus PEG-Interferon in Non-Cirrhotic Hepatitis C Patients Who Did Not Respond to Interferon or Interferon Plus Ribavirin
  ClinicalTrials.gov Identifier: NCT00040027 - Active, not recruiting
  Hepatitis C; Hepatitis C, Chronic
  
• The Efficacy of Alpha-Blockers for Expulsion of Distal Ureteral Stones
  ClinicalTrials.gov Identifier: NCT00451061 - Not yet recruiting
  Renal Colic
  
• Alpha-Adrenoceptor Vascular Function In Chronic Kidney Disease Focus On The Role Of Endothelial Nitric Oxide
  ClinicalTrials.gov Identifier: NCT00356265 - Recruiting
  Chronic Kidney Disease; Hypertension
  
• Effects of TNF-Alpha Antagonism (Etanercept) in Patients With the Metabolic Syndrome and Psoriasis
  ClinicalTrials.gov Identifier: NCT00477191 - Recruiting
  Psoriasis; Metabolic Syndrome; Hyperlipidemia; Obesity; Hypertension
  
• High-Dose Gleevec Alone or in Combination with Peg-Intron and GM-CSF in Early Phase Chronic Myelogenous Leukemia (CML)
  ClinicalTrials.gov Identifier: NCT00050531 - Active, not recruiting
  Leukemia, Myeloid, Chronic
  
• The Effect of 5-alpha Reductase on Testosterone in Men
  ClinicalTrials.gov Identifier: NCT00070733 - Recruiting
  Sex Disorders
  
• Darbepoetin Alpha in Myelodysplastic Syndromes (MDS)
  ClinicalTrials.gov Identifier: NCT00443339 - Recruiting
  Myelodysplastic Syndromes
  
• 17OHP for Reduction of Neonatal Morbidity Due to PTB in Twin and Triplet Pregnancies.
  ClinicalTrials.gov Identifier: NCT00163020 - Recruiting
  Preterm Birth
  
• Lumbar Spinal Fibrosis and TNF Alpha Inhibition
  ClinicalTrials.gov Identifier: NCT00385086 - Recruiting
  Post Operative Sciatica by Lumbar Spinal Fibrosis
  
• Hypoxia Inducible factor1-Alpha Genetic Polymorphism of Obstructive Sleep Apnea
  ClinicalTrials.gov Identifier: NCT00498693 - Recruiting
  Sleep Apnea, Obstructive
  
• An Intervention Trial for Cardiac Neuropathy in Type 1 Diabetes
  ClinicalTrials.gov Identifier: NCT00116207 - Recruiting
  Diabetic Autonomic Neuropathy
  
• Interferon-Gamma With Interferon Alpha and Ribavirin for Hepatitis C Non-Responders
  ClinicalTrials.gov Identifier: NCT00538811 - Recruiting
  Hepatitis C; Genotype 3; Non-Responders; Relapsers
  
• Phase II Trial of Peginterferon alpha-2b and Thalidomide in Adults with Recurrent Gliomas
  ClinicalTrials.gov Identifier: NCT00047879 - Recruiting
  Glioma
  
• A Trial of Thymalfasin in Adult Patients with Hepatocellular Carcinoma
  ClinicalTrials.gov Identifier: NCT00082082 - Recruiting
  Carcinoma, Hepatocellular
  
• CVD Risk and Prevention in Early Glucose Intolerance
  ClinicalTrials.gov Identifier: NCT00122447 - Recruiting
  Impaired Glucose Tolerance (IGT)
  
• Genetic and Biochemical Markers of Interferon-Induced Depression.
  ClinicalTrials.gov Identifier: NCT00252538 - Recruiting
  Hepatitis; Depression
  
• Pegylated Interferon and Ribavirin to Treat Chronic Hepatitis C with and without Kidney Disease
  ClinicalTrials.gov Identifier: NCT00028093 - Recruiting
  Hepatitis C
  
• Prevention of cognitive decline in Alzheimer's disease by ingested interferon alpha
  ClinicalTrials.gov Identifier: NCT00031018 - Recruiting
  Memory Disorders; Alzheimer's Disease
  
• Phase IB, Multicenter, Randomized, Double-Blind Placebo-Controlled, Dose-Escalation Study w/Open-Label Extension to Evaluate Safety and Tolerability of Multiple IV Doses of MEDI-545; A Fully Human Anti-IFN-Alpha Monoclonal Antibody in Patients w/SLE
  ClinicalTrials.gov Identifier: NCT00566163 - Recruiting
  Systemic Lupus Erythematosus; Multiple Intravenous Doses; Pharmokinetics
  
• Alpha Omega Trial
  ClinicalTrials.gov Identifier: NCT00139464 - Active, not recruiting
  Cardiovascular Diseases; Coronary Disease; Coronary Heart Disease Risk Reduction; Heart Diseases; Myocardial Infarction
  
• NGR-TNF in Treating Patients With Advanced Solid Tumors
  ClinicalTrials.gov Identifier: NCT00098943 - Active, not recruiting
  adult solid tumor; Endocrine Cancer; Gastrointestinal Cancer; Head and Neck Cancer; kidney and urinary cancer