CD4 Clinical Trials

• Evaluation of HIV-Negative Patients with Low CD4+ T Lymphocyte Counts
  ClinicalTrials.gov Identifier: NCT00001319 - Completed
  CD4 Lymphocytopenia; Idiopathic CD4 Positive T Lymphocytopenia
  
• Phase II/III Study Evaluating the Effect of IL-2 on Preservation of the CD4 T-Lymphocytes After Interruption of Antiretroviral Treatment in HIV-Infected Patients with CD4 T-Lymphocyte Count Greater Than 500 Cells/mm3 Who Have Received Antiretroviral Treat
  ClinicalTrials.gov Identifier: NCT00071890 - Active, not recruiting
  HIV Infections
  
• The Relationship of Single Nucleotide Polymorphisms in the Interleukin-7 Receptor-α Gene to CD4+ Immune Recovery in HIV Infected Patients Who Begin Antiretroviral Treatment With HAART
  ClinicalTrials.gov Identifier: NCT00168207 - Active, not recruiting
  HIV Infections
  
• Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients with Low CD4+ Counts (SILCAAT Study)
  ClinicalTrials.gov Identifier: NCT00013611 - Active, not recruiting
  HIV Infection
  
• A Study to Evaluate the Effects of Giving Proleukin (rIL-2) to HIV-Positive Patients with CD4 Counts Greater than 300 Cells/mm3
  ClinicalTrials.gov Identifier: NCT00000949 - Active, not recruiting
  HIV Infections
  
• Administration of Growth Hormone to Increase CD4+ Count in Patients Taking Anti-HIV Drugs
  ClinicalTrials.gov Identifier: NCT00050921 - Active, not recruiting
  HIV Infections
  
• Effects of Giving Interleukin-2 (IL-2) Plus Anti-HIV Therapy to HIV-Positive Patients with CD4 Cell Counts of at Least 350 Cells/mm3
  ClinicalTrials.gov Identifier: NCT00000948 - Active, not recruiting
  HIV Infections
  
• The Effects of Giving Interleukin-2 (IL-2) Plus Anti-HIV Therapy to HIV-Positive Patients with CD4 Cell Counts of at Least 350 Cells/mm3
  ClinicalTrials.gov Identifier: NCT00000825 - Active, not recruiting
  HIV Infections
  
• A Study to Evaluate the Effects of Giving IL-2 Alone to HIV-Positive Patients with CD4 Cell Counts of at Least 350 Cells/mm3 Who Do Not Wish to Receive Anti-HIV Therapy
  ClinicalTrials.gov Identifier: NCT00000909 - Active, not recruiting
  HIV Infections
  
• A Study to Evaluate the Effects of Giving Interleukin-2 (IL-2) Plus Anti-HIV Therapy to HIV-Positive Patients with CD4 Cell Counts of at Least 350 Cells/mm3
  ClinicalTrials.gov Identifier: NCT00000889 - Active, not recruiting
  HIV Infections
  
• Elimination of CD4+CD25+ Regulatory T Cells in HCC Patients
  ClinicalTrials.gov Identifier: NCT00396682 - Recruiting
  Advanced HCC
  
• Effectiveness of Palifermin in Increasing CD4 Counts in Treatment-Experienced HIV Infected Adults
  ClinicalTrials.gov Identifier: NCT00376935 - Recruiting
  HIV Infections
  
• Once-Daily Antiretroviral Therapy in HIV-1 Infected Patients With CD4+ Cell Counts Below 100 Cells/Mcl
  ClinicalTrials.gov Identifier: NCT00532168 - Recruiting
  HIV Infections
  
• A Randomized Trial of the Efficacy and Safety of a Strategy of Starting with Nelfinavir Versus Ritonavir Added to Background Antiretroviral (AR) Nucleoside Therapy in HIV-Infected Individuals with CD4+ Cell Counts Less than or Equal to 200/mm3
  ClinicalTrials.gov Identifier: NCT00000859 - Active, not recruiting
  HIV Infections
  
• A Phase I Study of Recombinant CD4(rCD4) in Patients With AIDS and AIDS-Related Complex
  ClinicalTrials.gov Identifier: NCT00002005 - Completed
  HIV Infections
  
• A Pharmacokinetic and Tolerance Study of Oral Ganciclovir in HIV-Infected Children With Asymptomatic Cytomegalovirus Infection and Low CD4 Cell Counts or Quiescent Cytomegalovirus Disease
  ClinicalTrials.gov Identifier: NCT00000805 - Active, not recruiting
  Cytomegalovirus Infections; HIV Infections
  
• Long-Term Assessment for Metabolic, Cardiovascular and Neurologic Problems in HIV-Infected Patients with Increased CD4 Cells Counts Following Anti-HIV Therapy
  ClinicalTrials.gov Identifier: NCT00000883 - Active, not recruiting
  Mycobacterium avium-intracellulare Infection; HIV Infections
  
• A Phase I Study of the Safety and Pharmacokinetics of Recombinant CD4 (rCD4) in Infants and Children Infected With or at Risk for HIV Infection
  ClinicalTrials.gov Identifier: NCT00000984 - Completed
  HIV Infections
  
• A Phase I Study of the Safety and Pharmacokinetics of Recombinant CD4 (rCD4) in Patients With AIDS and AIDS-Related Complex
  ClinicalTrials.gov Identifier: NCT00002004 - Completed
  HIV Infections
  
• Safety and Efficacy of PRO 542 in the Treatment of HIV-Infected Patients
  ClinicalTrials.gov Identifier: NCT00055185 - Active, not recruiting
  HIV Infections; Acquired Immune Deficiency Syndrome
  
• Zidovudine / Lamivudine + Nevirapine Twice Daily, Versus Tenofovir + Lamivudine + Nevirapine Once Daily in ARV-Naive Patients
  ClinicalTrials.gov Identifier: NCT00199979 - Recruiting
  Hiv Infection With Antiretroviral Therapy Indication; CD4 Below 350/µL or Below 15%
  
• The Use of Anti-CD4 Monoclonal Antibody (mAb)-Fragment for the Imaging of Chronic Inflammation in Patients With Active Rheumatoid Arthritis
  ClinicalTrials.gov Identifier: NCT00372177 - Recruiting
  Rheumatoid Arthritis; Polyarthritis; Rheumatism; Autoimmune Disease; Inflammation
  
• Study of Human Monoclonal Antibody to Treat Mycosis Fungoides (T-Cell Lymphoma)
  ClinicalTrials.gov Identifier: NCT00127881 - Recruiting
  Mycosis Fungoides
  
• A Phase I Study of the Safety and Pharmacokinetics of Recombinant CD4 Immunoglobulin G (rCD4-IgG) in Infants and Children With Documented HIV-1 Infection
  ClinicalTrials.gov Identifier: NCT00000663 - Completed
  HIV Infections
  
• Relationship of Viral Resistance Development to CD4 Monitoring Alone or With Viral Load Monitoring
  ClinicalTrials.gov Identifier: NCT00434070 - Recruiting
  Acquired Immunodeficiency Syndrome; Resistance
  
• A Phase I Study of the Safety and Pharmacokinetics of Recombinant Human CD4 Immunoglobulin (rCd4-IgG) Administered by Intravenous Bolus in Patients With AIDS and AIDS Related Complex
  ClinicalTrials.gov Identifier: NCT00000675 - Completed
  HIV Infections
  
• Safety and Effectiveness of CD4-IgG2 in HIV-Positive Children
  ClinicalTrials.gov Identifier: NCT00000876 - Completed
  HIV Infections
  
• Trial with HuMax-CD4 in Patients with Rheumatoid Arthritis Failing Treatment with Methotrexate and a TNF-alpha blocker
  ClinicalTrials.gov Identifier: NCT00042406 - Completed
  Rheumatoid Arthritis
  
• Clinical Trial of HuMax-CD4, a new drug to treat Advanced Stage T-Cell Lymphoma in the skin.
  ClinicalTrials.gov Identifier: NCT00071084 - Completed
  Cutaneous T-Cell Lymphoma
  
• Clinical Trial of HuMax-CD4, a new drug to treat Early Stage T-Cell Lymphoma in the skin.
  ClinicalTrials.gov Identifier: NCT00071071 - Completed
  Cutaneous T-Cell Lymphoma
  
• Depletion of Latent HIV in CD4 Cells
  ClinicalTrials.gov Identifier: NCT00576290 - Not yet recruiting
  HIV Infections
  
• A Randomized, Open-Label, Phase II, International Study of Subcutaneous Recombinant Interleukin-2 (Proleukin) With and Without Concomitant Antiretroviral Therapy in Patients with HIV-1 Infection and CD4+ Cell Counts Greater Than or Equal to 300/mm(3)
  ClinicalTrials.gov Identifier: NCT00106730 - Recruiting
  
  
• A Phase I Study of the Safety and Pharmacokinetics of Recombinant Human CD4-Immunoglobulin G (rCD4-IgG) Administered by Intravenous Bolus Injection in Combination With Oral Zidovudine in Patients With AIDS and AIDS-Related Complex
  ClinicalTrials.gov Identifier: NCT00000976 - Completed
  HIV Infections
  
• Raltegravir Added to Stable HAART in HIV-1 Infected Subjects With Viral Suppression and Low CD4 Recovery
  ClinicalTrials.gov Identifier: NCT00562510 - Not yet recruiting
  HIV Infections
  
• A Phase I Study of the Safety and Pharmacokinetics of Recombinant CD4 Immunoglobulin G (rCD4-IgG) in HIV-1 Seropositive Women During the Last Trimester of Pregnancy and Their Newborns
  ClinicalTrials.gov Identifier: NCT00000642 - Completed
  HIV Infections; Pregnancy
  
• An Open Trial Combining Zidovudine, Interferon-alfa, and Recombinant CD4-IgG With Transplantation of Syngeneic Bone Marrow and Peripheral Blood Lymphocytes From Healthy gp160-Immunized Donors in the Treatment of Patients With HIV Infection
  ClinicalTrials.gov Identifier: NCT00000647 - Completed
  HIV Infections
  
• A Phase I/II Double-Blind Controlled Trial to Determine the Safety and Immunogenicity of HIV-1 MN rgp160 Immuno AG Vaccine Therapy in HIV-Infected Individuals with Greater than or Equal to 500/mm3 CD4+ T Cells and 200-400/mm3 CD4+ T Cells
  ClinicalTrials.gov Identifier: NCT00000822 - Completed
  HIV Infections
  
• A Phase I Study of Recombinant Human CD4 Immunoglobulin G (rCD4-lgG) in Patients with HIV-Associated Immune Thrombocytopenic Purpura
  ClinicalTrials.gov Identifier: NCT00002250 - Completed
  Immune thrombocytopenic purpura ( ITP ); HIV Infections
  
• Immunological and Viral Response to Antiretrovirals in HIV Patients With CD4 Cell Count Below 100
  ClinicalTrials.gov Identifier: NCT00385957 - Completed
  HIV Infections
  
• Study to Evaluate Changes in CD4 on Replacing TDF With ABC or DDI+TDF With ABC+3TC
  ClinicalTrials.gov Identifier: NCT00338390 - Completed
  HIV Infections
  
• An Escalating Dose Tolerance Trial of BG8962 (rCD4) in Patients Who Are HIV Antibody Positive
  ClinicalTrials.gov Identifier: NCT00000721 - Completed
  HIV Infections
  
• An Expanded Access Open-Label, Compassionate Use Protocol of Remune in HIV-1-Infected Adults With CD4 Count Less Than 300 cells/ml
  ClinicalTrials.gov Identifier: NCT00002172 - Completed
  HIV Infections
  
• Evaluation of the Safety and Tolerance of Immunotherapy With Autologous, Ex-Vivo Expanded, HIV-Specific Cytotoxic T-Cells in HIV-Infected Patients With CD4+ Counts Between 100-400/mm3
  ClinicalTrials.gov Identifier: NCT00000756 - Completed
  HIV Infections
  
• Pilot Study to Evaluate the Efficacy of Zidovudine in Preventing CD4+ Lymphocyte Decline in Patients With Primary HIV Infection. (One treatment arm receives placebo)
  ClinicalTrials.gov Identifier: NCT00000765 - Completed
  HIV Infections
  
• A Study to Evaluate the Effect of Cimetidine on CD4 Lymphocyte Counts in HIV Infection
  ClinicalTrials.gov Identifier: NCT00002092 - Completed
  HIV Infections
  
• An Open-Label, Pilot Study to Evaluate the Development of Resistance to Nevirapine (BI-RG-587) in HIV-Infected Patients With CD4 Cell Count >= 500/mm3
  ClinicalTrials.gov Identifier: NCT00000747 - Completed
  HIV Infections
  
• An Expanded Access Open Label Protocol of Remune (HIV-1 Immunogen) in HIV-1-Infected Adults With CD4 Count 550 Cells /ml and Greater.
  ClinicalTrials.gov Identifier: NCT00002173 - Completed
  HIV Infections
  
• A Phase I Study of Three Doses of OPC-8212 (Vesnarinone) in HIV-Infected Persons With CD4+ Cell Number > 300 Cells/mm3
  ClinicalTrials.gov Identifier: NCT00002129 - Completed
  HIV Infections
  
• A Phase I Dose Escalation Study of Synthetic Hypericin in HIV-Infected Patients With Less Than 300 CD4 Lymphocytes
  ClinicalTrials.gov Identifier: NCT00000645 - Completed
  HIV Infections
  
• A Randomized, Double-Blind, Four-Arm Study Comparing Combination Nucleoside, Alternating Nucleoside, and Triple-Drug Therapy for the Treatment of Advanced HIV Disease (CD4 <= 50/mm3)
  ClinicalTrials.gov Identifier: NCT00000781 - Completed
  HIV Infections
  
• A Phase I/II Trial of Vaccine Therapy of HIV-1 Infected Individuals With 50-500 CD4 Cells/mm3
  ClinicalTrials.gov Identifier: NCT00000755 - Completed
  HIV Infections
  
• An Open-Label, Staggered Rising Dose Cohort Study Assessing the Pharmacokinetics, Safety, and Tolerance of BI-RG-587 in Combination With Zidovudine in Patients with HIV Infection (CD4+ Cell Count < 400/mm3)
  ClinicalTrials.gov Identifier: NCT00000649 - Completed
  HIV Infections
  
• Evaluation of the Changes in HIV-1 Burden in Peripheral Blood and Lymphoid Tissue Following Zidovudine ( AZT ) Treatment in HIV-1-Infected Patients With CD4+ Cells Between 100 and 500 Cells/mm3.
  ClinicalTrials.gov Identifier: NCT00000818 - Completed
  HIV Infections
  
• A Randomized, Double-Blind Phase II/III Trial of Monotherapy vs. Combination Therapy With Nucleoside Analogs in HIV-Infected Persons With CD4 Cells of 200-500/mm3
  ClinicalTrials.gov Identifier: NCT00000625 - Completed
  HIV Infections
  
• A Multicenter, Double Blind, Comparative Study of Zidovudine Alone Versus Zidovudine and Acyclovir as Treatment for HIV-Infected Patients With CD4+ Counts Less Than 200 Cells/mm3
  ClinicalTrials.gov Identifier: NCT00000712 - Completed
  HIV Infections
  
• A Double-Blind, Placebo-Controlled Trial of Paromomycin for Treatment of Cryptosporidiosis in Patients With Advanced HIV Disease and CD4 Counts Under 150 Cells/mm3
  ClinicalTrials.gov Identifier: NCT00000771 - Completed
  Cryptosporidiosis; HIV Infections
  
• A Pilot Randomized, Double-Blind, Placebo-Controlled, Parallel Design, Multicenter Trial to Evaluate the Effect of Ranitidine on Immunologic Indicators in Asymptomatic HIV-1 Infected Subjects With a CD4 Cell Count Between 400-700 Cells/mm3
  ClinicalTrials.gov Identifier: NCT00002106 - Completed
  HIV Infections
  
• A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Adefovir Dipivoxil When Added to Standard Antiretroviral Therapy for the Treatment of HIV-Infected Patients With CD4 Cell Counts >= 200/mm3
  ClinicalTrials.gov Identifier: NCT00002161 - Completed
  HIV Infections
  
• A Phase I/II Dose Escalation Study of Intradermal gp160 to Evaluate Safety, Delayed Type Hypersensitivity (Skin Test) Responses and Immunogenicity in Asymptomatic HIV Seropositive Patients With More Than 400 CD4+ Cells
  ClinicalTrials.gov Identifier: NCT00000667 - Completed
  HIV Infections
  
• A Multicenter, Prospective, Randomized, Double-Blind, Placebo-Controlled Trial of Three Preparations of Low-Dose Oral Alpha Interferon in HIV-Infected Patients With CD4+ Counts >= 50 and <= 350 Cells/mm3
  ClinicalTrials.gov Identifier: NCT00000844 - Completed
  HIV Infections
  
• Initial Phase II Efficacy and Safety Study of SC-48334 Administered in Combination with Low-Dose Zidovudine (AZT) to Symptomatic HIV-1 Infected Patients With = or > 200 to = or < 500 CD4+ Cells/mm3
  ClinicalTrials.gov Identifier: NCT00001993 - Completed
  HIV Infections
  
• A Study to Evaluate the Impact of Stopping Treatment for the Prevention of Pneumonia in HIV-Positive Patients Receiving Anti-HIV Drugs Who Have Increased CD4 Cell Counts
  ClinicalTrials.gov Identifier: NCT00000908 - Completed
  Pneumonia, Pneumocystis carinii; HIV Infections
  
• A Pilot, Open-Label, Phase II, Randomized Study to Determine the Effects of Viracept on the Outcome of Cutaneous and Mucosal KS in AIDS Patients with CD4 <= 500 cells/mm3
  ClinicalTrials.gov Identifier: NCT00002185 - Completed
  Sarcoma, Kaposi; HIV Infections
  
• A Double-Blind, Randomized, Comparative Study of Delavirdine Mesylate (U-90152S) in Combination With Didanosine (ddI) Versus ddI Alone in HIV-1 Infected Individuals With CD4 Counts of <= 300/mm3
  ClinicalTrials.gov Identifier: NCT00002123 - Completed
  HIV Infections
  
• A Maintenance Extension of Phase I Pilot Study of Chimeric Anti-CD4 Antibody M-T412 in Patients With Multiple Sclerosis
  ClinicalTrials.gov Identifier: NCT00004816 - Completed
  Multiple Sclerosis
  
• A Double-Blind, Randomized, Dose Response Study of Three Doses of Delavirdine Mesylate (U-90152S) in Combination with Zidovudine (ZDV) versus ZDV alone in HIV-1 Infected Individuals with CD4 Counts of 200-500mm3
  ClinicalTrials.gov Identifier: NCT00002124 - Completed
  HIV Infections
  
• A Study to Evaluate the Effects of Interleukin-12 (rhIL-12) in HIV-Positive Patients with CD4 Cell Counts Less than 50 Cells/mm3 or 300-500 Cells/mm3
  ClinicalTrials.gov Identifier: NCT00000857 - Completed
  HIV Infections
  
• Efficacy of Elevated CD4 Counts on CMV Retinitis
  ClinicalTrials.gov Identifier: NCT00091884 - Completed
  Acquired Immunodeficiency Syndrome; Cytomegalovirus Retinitis
  
• Active Immunization of HIV-1 Infected, Pregnant Women With CD4 Lymphocyte Counts >= 400/mm3: A Phase I Study of Safety and Immunogenicity of MN rgp120/HIV-1 Vaccine (NOTE: Some Patients Receive Placebo)
  ClinicalTrials.gov Identifier: NCT00001041 - Completed
  HIV Infections; Pregnancy
  
• A Multicenter, Double-Blind, Phase III, Adjuvant-Controlled Study of the Effect of 10 Units of HIV-1 Immunogen (Remune) Compared to Incomplete Freund's Adjuvant (IFA) Alone Every 12 Weeks on AIDS-Free Survival in Subjects With HIV Infection and CD4 T-Lymp
  ClinicalTrials.gov Identifier: NCT00002359 - Completed
  HIV Infections
  
• Phase II Study of the Safety and Surrogate Marker Efficacy of Butyldeoxynojirimycin (SC-48334) and AZT in Symptomatic HIV-1 Infected Patients with 200 - 500 CD4+ Cells/mm3. (NOTE: Asymptomatic HIV-1 Infected Patients Also Eligible)
  ClinicalTrials.gov Identifier: NCT00002079 - Completed
  HIV Infections
  
• Rifabutin Therapy for the Prevention of Mycobacterium avium Complex (MAC) Bacteremia in AIDS Patients With CD4 Counts = or < 200: A Double-Blind, Placebo-Controlled Trial
  ClinicalTrials.gov Identifier: NCT00002032 - Completed
  Mycobacterium avium-intracellulare Infection; HIV Infections
  
• Rifabutin Therapy for the Prevention of Mycobacterium avium Complex (MAC) Bacteremia in AIDS Patients With CD4 Counts = or < 200: A Double-Blind, Placebo-Controlled Trial
  ClinicalTrials.gov Identifier: NCT00002267 - Completed
  Mycobacterium avium-intracellulare Infection; HIV Infections
  
• Twins Study of Gene Therapy for HIV Infection
  ClinicalTrials.gov Identifier: NCT00001535 - Completed
  Acquired Immunodeficiency Syndrome; HIV Infection; Kaposi's Sarcoma
  
• An Open Trial of Zidovudine (AZT) Treatment of the AIDS Dementia Complex in Patients With AIDS or Low CD4+ Lymphocyte Counts
  ClinicalTrials.gov Identifier: NCT00000709 - Completed
  AIDS Dementia Complex; HIV Infections
  
• Active Immunization of HIV-1 Infected, Pregnant Women With CD4 Lymphocyte Counts >= 400/mm3: A Phase I Study of Safety and Immunogenicity of VaxSyn Recombinant gp160 (NOTE: Some Patients Receive Placebo)
  ClinicalTrials.gov Identifier: NCT00000777 - Completed
  HIV Infections; Pregnancy; HIV Seronegativity
  
• A Phase I Comparative Blinded Trial of Several HIV-1 Derived Immunogens in Infected Individuals With >= 500 CD4 Cells/mm3
  ClinicalTrials.gov Identifier: NCT00000779 - Completed
  HIV Infections
  
• Rifabutin Therapy for the Prevention of Mycobacterium avium Complex (MAC) Bacteremia in HIV Positive Patients with CD4 Counts = or < 200: Treatment IND Study
  ClinicalTrials.gov Identifier: NCT00002080 - Completed
  Mycobacterium avium-intracellulare Infection; HIV Infections
  
• Staccato: A Trial of CD4 Guided Treatment Interruption, Compared to Continuous Treatment, for HIV Infection
  ClinicalTrials.gov Identifier: NCT00113126 - Completed
  HIV Infection; AIDS
  
• A Six-Month Safety and Antiviral Study in HIV-1 Seropositive, AZT-Experienced Patients With CD4 Counts Less Than or Equal to 50 Cells/mm3 to Evaluate MK-639 Alone Versus Zidovudine (AZT) and 3TC Versus the Combination of MK-639 With AZT/3TC
  ClinicalTrials.gov Identifier: NCT00002155 - Completed
  HIV Infections
  
• A Randomized Phase II Study of Two Doses of Interferon alfa-2a (IFN alfa-2a) in Combination With Zidovudine (AZT) and Dideoxycytidine (ddC) Versus AZT and ddC Only in Patients With HIV Infection and Less Than 400 CD4 Cells/mm3
  ClinicalTrials.gov Identifier: NCT00000754 - Completed
  HIV Infections
  
• Immune Reconstitution in naïve HIV Patients With CD4 <100 Cells/mL When Treated With Lopinavir or Efavirenz.
  ClinicalTrials.gov Identifier: NCT00386659 - Terminated
  HIV Infection
  
• A Phase II Trial of rsCD4 and AZT in Patients With AIDS or Advanced AIDS Related Complex (ARC)
  ClinicalTrials.gov Identifier: NCT00000659 - Terminated
  HIV Infections
  
• A Pilot Study of Immunization With HIV-1 Antigen Pulsed Allogenic Dendritic Cells in HIV-Infected Asymptomatic Patients With CD4+ T Cells > 350 cells/mm3
  ClinicalTrials.gov Identifier: NCT00001064 - Terminated
  HIV Infections